Summary

Splenic abscesses represent a rare but serious suppurative complication within the spleen, often arising through haematogenous spread, contiguous infection or following trauma and interventional procedures. Clinical presentation is typically insidious, with fever, left upper quadrant pain and leukocytosis being the most frequent findings; however, nonspecific manifestations can delay diagnosis. Imaging modalities—particularly contrast-enhanced CT and ultrasonography—are indispensable for early detection and characterisation of abscess number, size and loculation. Management strategies balance systemic antimicrobial therapy with either minimally invasive drainage techniques or surgical intervention. Percutaneous aspiration or catheter drainage under imaging guidance has gained traction for unilocular or small-volume collections, especially in patients with high operative risk or in whom splenic preservation is desirable. Splenectomy remains a definitive option in multifocal, large or refractory abscesses and in cases complicated by haemodynamic instability or rupture. Recent advances have refined patient selection criteria for conservative versus surgical approaches, emphasising individual risk factors, abscess anatomy and underlying comorbidities. A multidisciplinary framework involving infectious disease specialists, interventional radiologists and surgeons ensures optimal outcomes while minimising morbidity and preserving immune function where possible.

Research from Nature Portfolio

No recent Nature Portfolio content available.

Management of Splenic Abscesses publication trend

The graph below shows the total number of articles in management of splenic abscesses across all publications each year (not limited to Nature Index journals).

Technical terms

Splenic abscess: A localised collection of pus within the splenic parenchyma resulting from infection.

Haematogenous spread: Dissemination of infectious agents through the bloodstream to distant organs.

Percutaneous drainage: A minimally invasive procedure to evacuate fluid or pus using a needle or catheter under imaging guidance.

Contrast-enhanced CT scan: Computed tomography performed with intravenous contrast medium to delineate lesions by improving soft-tissue contrast.

Splenectomy: Surgical removal of the spleen, indicated when abscesses are large, multiloculated or refractory to conservative measures.

References

  1. Splenic Abscess: An Uncommon Entity with Potentially Life‐Threatening Evolution. Canadian Journal of Infectious Diseases and Medical Microbiology (2018).
  2. Splenic Abscesses in the Pediatric Population: A Literature Review of an Uncommon Entity. Cureus (2024).
  3. Splenic abscess due to non-operative management of splenic injury: a case report. Journal of Medical Case Reports (2023).
  4. Splenic abscess secondary to COVID-19 acute infection: A case report and literature review. Medicine (2024).

About these summaries

This Nature Research Intelligence Topic summary is created with the cited references and a large language model. We take care to ground generated text with facts, and have systems in place to gain human feedback on the overall quality of the process in line with our AI principles. We strive to create accurate and useful summaries for people unfamiliar with the research topic and that supports this goal. These pages are a beta release and will be updated as we learn how best to help people gain value from a research topic summary.

Nature Strategy Reports
Turn complex research questions into confident strategic decisions 

When you're under pressure to set direction, justify investment, or understand your competitive position, you need more than raw data — you need trusted insights you can act on.

  • Benchmark your performance against global peers using robust, methodologically sound analysis.

  • Combine quantitative metrics with qualitative expert insight to uncover strengths, gaps and emerging opportunities.

  • Gain tailored, decision-ready recommendations aligned to your strategic priorities.

Talk to us to learn more about our data dashboards and bespoke strategy reports.

Nature Masterclasses
Grow research skills, confidence and careers with training built for every stage of the research lifecycle.

Developed with Nature Portfolio journal Editors and internationally renowned experts. Discover three ways to learn:

  • Self-paced, online courses in convenient bite-sized units, covering key skills across scientific writing, publishing, grant writing, data analysis, and more.

  • Expert trainer-led workshops with hands-on exercises and real-time feedback across core research skills, delivered via interactive group sessions.

  • Editor-led workshops combining core principles in writing and publishing, personalised 1:1 feedback from Nature Portfolio Editors and hands-on exercises.

Explore course catalogues and workshop agendas, enquire about the options or request institutional pricing.