Mondor's Disease: Clinical Manifestations and Treatment Approaches
Summary
Mondor’s disease is a rare, benign condition characterised by superficial thrombophlebitis of the anterolateral thoracoabdominal wall, most frequently affecting the breast and chest but also reported in the penile and abdominal regions. Clinically, it presents as a tender, cord-like induration beneath the skin, often accompanied by localised erythema and discomfort on movement. The aetiology remains poorly understood but is commonly linked to minor trauma, hypercoagulable states, hormonal changes or vigorous physical activity. Diagnosis is predominantly clinical, supported by Doppler ultrasonography to visualise non-compressible, thrombosed veins and to exclude alternative pathologies. Management is primarily conservative, focusing on anti-inflammatory medication, warm compresses and rest, with most cases resolving within weeks without sequelae. Attention to differential diagnoses such as malignancy, vasculitis or musculoskeletal disorders is vital to avoid unnecessary invasive procedures. Recent research has explored the pathophysiological mechanisms, optimised imaging protocols and highlighted the importance of clinician awareness to ensure timely identification and tailored management strategies.
Research from Nature Portfolio
No recent Nature Portfolio content available.
Mondor's Disease: Clinical Manifestations and Treatment Approaches publication trend
The graph below shows the total number of articles in mondor's disease: clinical manifestations and treatment approaches across all publications each year (not limited to Nature Index journals).
Technical terms
Superficial thrombophlebitis: Inflammation and clotting of veins located close to the skin surface.
Cord-like induration: A palpable, firm, linear band beneath the skin, characteristic of thrombosed superficial veins.
Doppler ultrasonography: A non-invasive imaging technique employing sound waves to visualise blood flow within vessels.
Hypercoagulable state: A physiological condition predisposing to excessive blood clot formation within the circulation.
References
- Breast Pain Differential: Mondor’s Disease of the Breast. Journal of Investigative Medicine High Impact Case Reports (2024).
- Mondor’s disease of the breast: a case series. Journal of Medical Case Reports (2021).
- Penile Mondor’s Disease: Rare Association With Excessive Masturbation. Cureus (2020).
Turn complex research questions into confident strategic decisions
When you're under pressure to set direction, justify investment, or understand your competitive position, you need more than raw data — you need trusted insights you can act on.
Benchmark your performance against global peers using robust, methodologically sound analysis.
Combine quantitative metrics with qualitative expert insight to uncover strengths, gaps and emerging opportunities.
Gain tailored, decision-ready recommendations aligned to your strategic priorities.
Talk to us to learn more about our data dashboards and bespoke strategy reports.
Grow research skills, confidence and careers with training built for every stage of the research lifecycle.
Developed with Nature Portfolio journal Editors and internationally renowned experts. Discover three ways to learn:
Self-paced, online courses in convenient bite-sized units, covering key skills across scientific writing, publishing, grant writing, data analysis, and more.
Expert trainer-led workshops with hands-on exercises and real-time feedback across core research skills, delivered via interactive group sessions.
Editor-led workshops combining core principles in writing and publishing, personalised 1:1 feedback from Nature Portfolio Editors and hands-on exercises.
Explore course catalogues and workshop agendas, enquire about the options or request institutional pricing.