Osseointegration and Bone Healing in Diabetic Models
Summary
Diabetes mellitus, through sustained hyperglycaemia and associated metabolic disturbances, compromises bone regeneration and implant integration. Impaired osteoblast function, dysregulated angiogenesis and chronic inflammation converge to weaken peri-implant bone quality and delay healing. Animal models of type 1 and type 2 diabetes, often induced by streptozotocin or genetic manipulation, recapitulate key features of human pathology and allow investigation of molecular mechanisms and therapeutic interventions. Recent studies focus on modifying stem cells, growth factors and implant surfaces to restore osteogenic potential, as well as on pharmacological agents that target signalling pathways disrupted by diabetes. Advancements in imaging, biomechanical testing and molecular profiling are refining our understanding of implant-bone interactions under diabetic conditions. The global burden of diabetes and the growing utilisation of dental and orthopaedic implants render this research vital for reducing failure rates and improving patient outcomes.
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Osseointegration and Bone Healing in Diabetic Models publication trend
The graph below shows the total number of articles in osseointegration and bone healing in diabetic models across all publications each year (not limited to Nature Index journals).
Technical terms
Osseointegration: Direct structural and functional connection between living bone and the surface of a load-bearing implant.
Adipose-derived stem cells (ADSCs): Multipotent progenitor cells from fat tissue capable of osteogenic differentiation and tissue repair.
Hyperglycaemia: Elevated blood glucose concentration that disrupts normal cellular functions and tissue healing.
AKT/mTOR/HIF-1α signalling pathway: A cascade regulating cell survival, growth and response to hypoxia; modulation influences osteogenesis and angiogenesis.
Insulin-like growth factor 1 (IGF-1): A growth factor that stimulates osteoblast proliferation and differentiation, enhancing bone formation.
References
- Inhibition of PTEN promotes osteointegration of titanium implants in type 2 diabetes by enhancing anti-inflammation and osteogenic capacity of adipose-derived stem cells. Frontiers in Bioengineering and Biotechnology (2024).
- Effect of Anti-Diabetic Medications on Dental Implants: A Scoping Review of Animal Studies and Their Relevance to Humans. Pharmaceuticals (2022).
- Engineered Chimeric Peptides with IGF-1 and Titanium-Binding Functions to Enhance Osteogenic Differentiation In Vitro under T2DM Condition. Materials (2022).
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