Pharmacological Properties of Celery Extracts
Summary
Extracts of Apium graveolens (celery) encompass a diverse spectrum of phytochemicals, including flavonoids, furanocoumarins, phenylpropanoids and essential oils, which collectively underpin a range of bioactivities. Antioxidant potential is widely reported via free-radical scavenging and metal-chelating mechanisms, supporting cellular redox balance. Anti-inflammatory effects arise from downregulation of pro-inflammatory enzymes and mediators, while antimicrobial actions span Gram-positive and Gram-negative bacteria through disruption of membrane integrity. Enzyme-inhibitory properties, notably against α-amylase and α-glucosidase, contribute to antihyperglycaemic activity comparable to standard therapeutics. Cardiovascular benefits include antihypertensive effects mediated by vasorelaxation and lipid-modulating pathways. Preclinical findings further suggest hepatoprotective and anticancer potential through apoptosis induction and modulation of detoxifying enzymes. The global appeal of celery extracts lies in their accessibility, low toxicity and versatility in formulation, from functional foods to topical applications. Interdisciplinary studies continue to elucidate structure–activity relationships of individual constituents and to optimise extraction methods for maximising pharmacological efficacy.
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Pharmacological Properties of Celery Extracts publication trend
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Technical terms
α-Amylase: Enzyme that hydrolyses starch into smaller carbohydrates.
α-Glucosidase: Enzyme that catalyses the final step of carbohydrate digestion.
IC50: Concentration of a substance required to inhibit a biological process by 50%.
FRAP assay: Method measuring ferric-to-ferrous ion reduction to assess antioxidant power.
ORAC assay: Oxygen radical absorbance capacity test quantifying radical-scavenging efficacy.
Minimum inhibitory concentration (MIC): Lowest concentration of an antimicrobial agent that prevents visible growth of a microorganism.
References
- Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia. International Journal of Biological Macromolecules (2024).
- Apium Plants: Beyond Simple Food and Phytopharmacological Applications. Applied Sciences (2019).
- Evaluation of bioactive components and antioxidant capacity of four celery (Apium graveolens L.) leaves and petioles. International Journal of Food Properties (2020).
- Antioxidant, Antimicrobial Activities and Characterization of Polyphenol-Enriched Extract of Egyptian Celery (Apium graveolens L., Apiaceae) Aerial Parts via UPLC/ESI/TOF-MS. Molecules (2022).
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