Phytochemical Applications in Hepatic Therapeutics
Summary
Phytochemicals, the bioactive compounds synthesised by plants, have emerged as a diverse source of hepatoprotective agents. Extensive research has focused on polyphenols and flavonolignans, notably extracts from milk thistle, which demonstrate antioxidant, anti-inflammatory and antifibrotic properties. These agents act by restoring redox homeostasis, modulating key signalling pathways such as nuclear factor-κB, and attenuating the expression of pro-inflammatory cytokines. They also influence lipid metabolism, insulin sensitivity and mitochondrial function, thereby addressing steatosis and nonalcoholic fatty liver disease. Beyond prevention of liver injury, phytochemicals have shown promise in slowing progression of fibrosis and supporting regeneration following toxic insult. Interest in clinical translation has driven studies of improved formulation strategies to overcome poor solubility and bioavailability, while mechanistic insights continue to refine target engagement and dosage optimisation. Overall, phytochemical therapeutics offer a multifaceted approach to liver health with global significance for chronic liver disease management.
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Phytochemical Applications in Hepatic Therapeutics publication trend
The graph below shows the total number of articles in phytochemical applications in hepatic therapeutics across all publications each year (not limited to Nature Index journals).
Technical terms
Phytochemical: A biologically active compound produced by plants, often with therapeutic potential.
Hepatoprotective: Descriptive of an agent that prevents or mitigates liver injury.
Oxidative stress: A cellular condition arising from imbalance between reactive oxygen species and antioxidant defences.
NF-κB: A transcription factor central to the regulation of inflammatory and immune responses.
Bioavailability: The proportion of an administered substance that reaches systemic circulation and target tissues.
References
- Silymarin and Inflammation: Food for Thoughts. Antioxidants (2024).
- Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules (2017).
- Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art.. Molecules (2019).
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