Phytochemical Properties and Therapeutic Applications of Agrimonia Species
Summary
Agrimonia species, long employed in European and Asian traditional medicine, are distinguished by a complex phytochemical profile that includes polyphenols, flavonoids, tannins, isocoumarins and triterpenes. Detailed spectroscopic and chromatographic characterisation of A. eupatoria and A. pilosa has revealed constituents such as quercetin, catechin, agrimonolide and diverse phenolic acids. These compounds confer potent antioxidant activity, as shown by radical-scavenging assays, and exert anti-inflammatory effects via downregulation of NF-κB signalling and pro-inflammatory cytokine production. Pharmacological investigations demonstrate antibacterial efficacy against multidrug-resistant pathogens, hepatoprotective and anti-inflammatory actions in animal models, and improvement of glycaemic control through α-glucosidase inhibition. Recent work on lipophosphonoxin combinations and blood–brain-barrier-permeable isocoumarins highlights the therapeutic breadth of Agrimonia extracts, spanning wound healing, metabolic disorders, neuroprotection and oncology. Integration of advanced phytochemical profiling with mechanistic pharmacology and formulation science is accelerating the clinical translation of Agrimonia-based agents worldwide.
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Phytochemical Properties and Therapeutic Applications of Agrimonia Species publication trend
The graph below shows the total number of articles in phytochemical properties and therapeutic applications of agrimonia species across all publications each year (not limited to Nature Index journals).
Technical terms
Polyphenol: A class of plant secondary metabolites characterised by multiple phenolic rings; known for antioxidant and anti-inflammatory properties.
Flavonoid: A subgroup of polyphenols based on a 15-carbon skeleton; widely recognised for free radical scavenging and enzyme-modulatory activities.
Isocoumarin: A lactone-containing heterocyclic compound often associated with anti-inflammatory, anticancer and neuroprotective effects.
Extracellular Matrix: A network of proteins and polysaccharides surrounding cells that provides structural support and regulates cell behaviour.
NF-κB: A nuclear transcription factor central to the regulation of immune and inflammatory responses, modulating gene expression in response to stress signals.
References
- Antioxidant and Protective Effects of the Polyphenolic Glycoconjugate from Agrimonia eupatoria L. Herb in the Prevention of Inflammation in Human Cells. Journal of Functional Biomaterials (2023).
- Current Progress and Outlook for Agrimonolide: A Promising Bioactive Compound from Agrimonia pilosa Ledeb.. Pharmaceuticals (2023).
- Assessment of Agrimonia eupatoria L. and Lipophosphonoxin (DR-6180) Combination for Wound Repair: Bridging the Gap Between Phytomedicine and Organic Chemistry. Biomolecules (2024).
- Glucosidase inhibitory activity and antioxidant activity of flavonoid compound and triterpenoid compound from Agrimonia Pilosa Ledeb. BMC Complementary Medicine and Therapies (2014).
- Phytochemical and Pharmacological Research in Agrimonia eupatoria L. Herb Extract with Anti-Inflammatory and Hepatoprotective Properties. Plants (2022).
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