Sleep Quality and Chronic Kidney Disease Management
Summary
Sleep disturbances are highly prevalent among individuals with chronic kidney disease (CKD), exerting a bidirectional influence on disease progression and patient well-being. Fragmented sleep, altered sleep architecture and circadian misalignment contribute to hypertension, metabolic dysregulation and heightened inflammatory tone, all of which accelerate renal decline. Conversely, uraemic toxins, fluid overload and restless-leg phenomena disrupt nocturnal rest, fostering a vicious cycle. Recognising and addressing sleep quality has therefore emerged as an integral component of CKD management, with strategies ranging from behavioural sleep hygiene and cognitive-behavioural therapy to optimisation of dialysis schedules and pharmacological interventions. Novel approaches, including wearable monitoring, telemedicine and personalised chronotherapy, offer promise for improving both sleep and renal outcomes. A global research effort spanning epidemiology, mechanistic studies and interventional trials highlights the potential for sleep-centred care to enhance quality of life, reduce cardiovascular risk and slow the trajectory of kidney impairment.
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Sleep Quality and Chronic Kidney Disease Management publication trend
The graph below shows the total number of articles in sleep quality and chronic kidney disease management across all publications each year (not limited to Nature Index journals).
Technical terms
Estimated glomerular filtration rate (eGFR): A calculated measure of kidney filtration capacity expressed in millilitres per minute per 1.73 m² of body surface area, used to define CKD stages.
Glomerular hyperfiltration: An abnormally high eGFR above age- and sex-specific thresholds that may precede kidney damage.
Albuminuria: The presence of albumin in urine, indicating glomerular injury and used as a marker of CKD progression.
Urinary albumin–creatinine ratio (UACR): A standardised laboratory index obtained by dividing urine albumin concentration by creatinine concentration, used to quantify albuminuria.
Genetic risk score: A summary estimate of inherited susceptibility to CKD, calculated by summing the effects of multiple risk-associated genetic variants.
References
- Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study. Nutrients (2024).
- Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women. PLOS ONE (2017).
- Sleep Patterns, Genetic Susceptibility, and Incident Chronic Kidney Disease: A Prospective Study of 370 671 Participants. Frontiers in Neuroscience (2022).
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