Surgical Management of Glioblastoma Variants
Summary
Glioblastoma variants encompass a spectrum of histopathological and molecular subtypes that challenge surgical strategy. Central to management is achieving maximal safe resection—removing the greatest tumour volume without compromising critical neurological function. Preoperative planning utilises advanced imaging, including diffusion tensor imaging and functional MRI, to map eloquent cortex and white-matter tracts. Intraoperative techniques such as fluorescence-guided surgery enhance delineation of infiltrative margins, particularly in non-enhancing tumour regions. Extent of resection remains a robust prognostic indicator across both IDH-mutant and wild-type tumours, multifocal presentations and those with corpus callosum invasion. In recurrent disease, patient selection based on performance status, focality and timing of progression guides repeat surgery, which may extend survival when integrated within a multidisciplinary framework that aligns surgical, radiotherapeutic and systemic approaches.
Research from Nature Portfolio
No recent Nature Portfolio content available.
Surgical Management of Glioblastoma Variants publication trend
The graph below shows the total number of articles in surgical management of glioblastoma variants across all publications each year (not limited to Nature Index journals).
Technical terms
Maximal safe resection: Surgical removal of as much tumour tissue as possible without causing unacceptable neurological deficits.
Fluorescence-guided surgery: Use of tumour-selective fluorescent agents during surgery (for example, 5-aminolevulinic acid) to improve visualisation of malignant tissue.
Gross-total resection: Complete macroscopic removal of the tumour as confirmed by postoperative imaging.
Corpus callosum invasion: Infiltration of the fibre tract connecting cerebral hemispheres, associated with a more aggressive disease course.
Performance status: Assessment of a patient’s ability to carry out daily activities, critical for tailoring treatment intensity.
References
- Effects of Reoperation Timing on Survival among Recurrent Glioblastoma Patients: A Retrospective Multicentric Descriptive Study. Cancers (2023).
- Surgery for IDH1/2 wild-type glioma invading the corpus callosum. Acta Neurochirurgica (2020).
- Repeated craniotomies for intracranial tumors: is the risk increased? Pooled analysis of two prospective, institutional registries of complications and outcomes. Journal of Neuro-Oncology (2018).
Turn complex research questions into confident strategic decisions
When you're under pressure to set direction, justify investment, or understand your competitive position, you need more than raw data — you need trusted insights you can act on.
Benchmark your performance against global peers using robust, methodologically sound analysis.
Combine quantitative metrics with qualitative expert insight to uncover strengths, gaps and emerging opportunities.
Gain tailored, decision-ready recommendations aligned to your strategic priorities.
Talk to us to learn more about our data dashboards and bespoke strategy reports.
Grow research skills, confidence and careers with training built for every stage of the research lifecycle.
Developed with Nature Portfolio journal Editors and internationally renowned experts. Discover three ways to learn:
Self-paced, online courses in convenient bite-sized units, covering key skills across scientific writing, publishing, grant writing, data analysis, and more.
Expert trainer-led workshops with hands-on exercises and real-time feedback across core research skills, delivered via interactive group sessions.
Editor-led workshops combining core principles in writing and publishing, personalised 1:1 feedback from Nature Portfolio Editors and hands-on exercises.
Explore course catalogues and workshop agendas, enquire about the options or request institutional pricing.