Wound Healing Techniques in Endoscopic Sinus Surgery
Summary
Endoscopic sinus surgery relies on precise mucosal preservation and optimal postoperative management to promote rapid and complication-free wound healing. Following removal of diseased tissue, haemostasis is achieved and the surgical cavity is either left to epithelialise or supported with a dressing. Traditional non-resorbable packs control bleeding but often cause patient discomfort on removal and may impair mucociliary clearance. Resorbable biomaterials—including chitosan, gelatin, hyaluronic acid and starch-derived matrices—offer haemostatic and anti-adhesive properties while gradually integrating into healing tissues. Drug-impregnated dressings deliver topical steroids or antibiotics to modulate inflammation and reduce crusting, whereas autologous therapies such as platelet-rich plasma (PRP) enhance proliferative phase activity by concentrating growth factors at the wound bed. Emerging composite scaffolds aim to combine structural support with controlled degradation and bioactive cargo delivery. Across all modalities, prevention of synechia formation and excessive granulation remains critical, with saline irrigation and targeted debridement serving as adjunctive measures. A multidisciplinary approach integrating surgical finesse, tailored biomaterials and adjuvant therapies underpins advances in sinonasal wound care.
Research from Nature Portfolio
No recent Nature Portfolio content available.
Wound Healing Techniques in Endoscopic Sinus Surgery publication trend
The graph below shows the total number of articles in wound healing techniques in endoscopic sinus surgery across all publications each year (not limited to Nature Index journals).
Technical terms
Endoscopic Sinus Surgery: A minimally invasive procedure using a fibre-optic endoscope to restore ventilation and drainage of the paranasal sinuses.
Nasal Packing: Placement of material within the nasal cavity postoperatively to control bleeding, support tissue and modulate healing.
Synechia: An abnormal adhesion between opposing mucosal surfaces within the nasal cavity or sinuses.
Granulation Tissue: Vascularised connective tissue formed during the proliferative phase of wound healing that fills surgical defects.
Platelet-Rich Plasma (PRP): Autologous blood derivative enriched in platelets and growth factors to accelerate tissue repair.
Biomaterial: A natural or synthetic substance engineered to interact with biological tissues for therapeutic or diagnostic purposes.
References
- Maximizing Postoperative Recovery: The Role of Functional Biomaterials as Nasal Packs—A Comprehensive Systematic Review without Meta-Analysis (SWiM). Pharmaceutics (2023).
- Biodegradable Gelatin–Carrageenan Sponges: High-Potential Functional Nasal Packs for Efficient Secretome Delivery. Polymers (2024).
- Steroid vs. antibiotic impregnated absorbable nasal packing for wound healing after endoscopic sinus surgery: a randomized, double blind, placebo-controlled study. Brazilian Journal of Otorhinolaryngology (2018).
- The impact of submucosal PRP injection on wound healing after endoscopic sinus surgery: a randomized clinical trial. European Archives of Oto-Rhino-Laryngology (2024).
About these summaries
This Nature Research Intelligence Topic summary is created with the cited references and a large language model. We take care to ground generated text with facts, and have systems in place to gain human feedback on the overall quality of the process in line with our AI principles. We strive to create accurate and useful summaries for people unfamiliar with the research topic and that supports this goal. These pages are a beta release and will be updated as we learn how best to help people gain value from a research topic summary.
Turn complex research questions into confident strategic decisions
When you're under pressure to set direction, justify investment, or understand your competitive position, you need more than raw data — you need trusted insights you can act on.
Benchmark your performance against global peers using robust, methodologically sound analysis.
Combine quantitative metrics with qualitative expert insight to uncover strengths, gaps and emerging opportunities.
Gain tailored, decision-ready recommendations aligned to your strategic priorities.
Talk to us to learn more about our data dashboards and bespoke strategy reports.
Grow research skills, confidence and careers with training built for every stage of the research lifecycle.
Developed with Nature Portfolio journal Editors and internationally renowned experts. Discover three ways to learn:
Self-paced, online courses in convenient bite-sized units, covering key skills across scientific writing, publishing, grant writing, data analysis, and more.
Expert trainer-led workshops with hands-on exercises and real-time feedback across core research skills, delivered via interactive group sessions.
Editor-led workshops combining core principles in writing and publishing, personalised 1:1 feedback from Nature Portfolio Editors and hands-on exercises.
Explore course catalogues and workshop agendas, enquire about the options or request institutional pricing.