Medical Biochemistry and Metabolomics articles for China

Time frame: 1 June 2025 - 30 May 2026

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Count: 374

Article ‘Count’ for Medical Biochemistry and Metabolomics.

Journal Count Share
6 6.00
Confined Oxidative Catabolism: Organelle-Level Reactive Oxygen Species for Precision Intervention in Metabolic-Associated Fatty Liver Disease 1.00
Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring 1.00
A Remote-Controlled Nanopump Delivers Oxygen to Boost Energy Production in Osteoarthritis 1.00
Amyloid Fibrillation of a Ninjurin-1-Derived α-Helical Peptide: Structural Insights into Conformational Transition 1.00
Activating Mitochondrial Complex I by Polyphenol Nanoparticle to Inhibit Hypoxia-Inducible Factor-1 Subunit α for Immunotherapy 1.00
Biomimetic Liposomes for G-Protein-Coupled Receptor 120 Exo/Endogenous Coactivation to Reprogram Lipid Metabolism in Obesity-Associated Osteoarthritis 1.00
1 1.00
A ROS/ultrasound dual-responsive nanocarrier enhances drug penetration for ameliorating metabolic dysfunction-associated steatohepatitis 1.00
5 5.00
Peptide Based Covalent Organic Framework for the Magnetic Resonance Imaging-Mediated Attenuation of Amyloid-β Fibrils 1.00
Injectable Tumor-Cell-Mimicking Topology Accelerates the Mechanical Reprogramming of Adipocytes via the Nucleus for Enhanced Metabolic Adaptation to Obesity 1.00
Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy 1.00
Thermo-Responsive Catalytic Hydrogel Enables Oncolytic Enzyme Therapy Through Cascading Plasma Membrane Rupture and Oxidative Stress Amplification 1.00
Mitochondrial‐Cytosolic Cascade Metabolic Regulation System: A Robust Strategy to Disrupt Multipath Energy Replenishment in Cancer Therapy 1.00
1 1.00
ALP-Responsive Luminescent Nanosheets Promote Precise Hepatitis Theragnostic by Co-Targeting NLRP3 and Cholestasis 1.00
9 6.95
Diabetes modifies the association between magnesium and insomnia, but not depressive symptomatology, in Puerto Rican adults: a prospective cohort study 0.19
Circulating saturated fatty acids and incident chronic kidney disease: a meta-analysis of de-novo prospective cohort investigations 0.10
Remission of impaired glucose tolerance by anthocyanin supplementation: a randomized, double-blind, and placebo-controlled trial 1.00
Plasma fatty acids and the likelihood of healthy aging: a prospective cohort study 1.00
Associations between domestic water hardness and the risk of experiencing fifteen different cardiovascular events: A prospective cohort study of 324,136 UK Biobank participants 1.00
Plasma fatty acids, genetic susceptibility, and colorectal cancer risk: results from a large prospective cohort study 1.00
Association between dietary fat intake and long-term risk of dementia: A prospective cohort study 0.77
Associations between serum bile acid profile and mortality in patients with coronary artery disease: a cohort study 0.89
Circulating Bile Acids, Bile Acids Receptor Polymorphisms, and Risk of Chronic Kidney Disease among Individuals with Newly Diagnosed Type 2 Diabetes: A Prospective Study 1.00
3 2.86
Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice 0.86
Single-cell sequencing has revealed the palmitoylation landscape in lung adenocarcinoma and identified ABHD17C as a novel biomarker 1.00
Metabolic dysfunction-associated steatotic liver disease in patients and mouse with Wilson’s disease 1.00
36 35.78
SQ-KFP: A Framework for Spatially Quantitative Metabolic Flux Analysis Enables Imaging the In Vivo Absolute Metabolic Enzymatic Reaction Rate 1.00
Hypoxia-Activated Probe for Targeted Photoacoustic Imaging and Photothermal Modulation of Adipose Tissue in Obesity 1.00
A Dual-Functional Two-Photon PLIM Probe Based on Ruthenium(II) Complex: Sequence Selectivity and Aβ Aggregation Monitoring 1.00
Combining Engineered Probe Library with Tiered Screening for the Rational Discovery of Alzheimer’s Diagnostic Probe with an Enhanced Signal-to-Noise Ratio 1.00
Rational Design of an Isoform-Specific Fluorogenic Probe for Human UGT2B7: Enabling Functional Analysis and Inhibitor Screening 1.00
Quantitatively Sensing Lipid Droplets Polarity in Cells and Atherosclerotic Model with a Novel Naphthalimide-Based Fluorescent Probe 1.00
Length-Dependent Aβ-Gelsolin Interactions Regulate Amyloid Aggregation in Alzheimer’s Disease 1.00
Electrochemistry Reveals the Accelerating Effect of Fluorinated Compounds on Early-Stage Amyloid Fibril Aggregation 1.00
Fe-Doped Carbon Dots Functionalized Nanoelectrode for In Situ Monitoring of Metabolism-Associated ROS Changes in Single Microglia 1.00
Trifluoromethylphenyl-Induced Specific Acyl Chain Fragmentation in Liquid Chromatography Mass Spectrometry for Free Furan Fatty Acid Screening in Fish Oils 0.90
Membrane-Targetable Dual-Responsive Fluorescent Probe for Simultaneous Detection of Polarity and Hypochlorite and Its Application in Apoptosis and Cancer Models 1.00
Dynamic Visualization of Amyloid-β Plaques with a Novel NIR-II Fluorescence Reporter 1.00
Amphiphilic Tetraphenylethylene Derivative with Hydrophobic–Hydrophilic Complementarity to Amyloid Oligomers for in Situ Imaging and Modulation of Membrane-Disruptive Neurotoxicity 1.00
An Iodinated BODIPY-Based Probe for the Selective Mapping and Disassembly of Amyloid-β Aggregates In Vivo 1.00
Integrating Ex Vivo Isotope Labeling with Mass Spectrometry Imaging to Spatially Trace Heterogeneous Metabolic Activity in Rat Kidney Tissue 1.00
Deep-Coverage Ubiquitylomics with Low Starting Materials Reveals Dysregulation of Ubiquitinated FASN as a Key Regulator of MAFLD Pathogenesis 1.00
Dual-Mode Chalcone-Based Fluorescent Probe for Distinguishing Amyloid-β Oligomers and Fibrils via Microenvironment Sensitivity 1.00
Rational Design of a Dual-Channel Fluorescent Probe for the Simultaneous Imaging of Brain Amyloid-β Plaques and HClO/ClO– in Alzheimer’s Disease 1.00
Simultaneous Dual-Channel Tracking Lipid Droplets Dynamic Behaviors and Revealing the Protective Role in Nonalcoholic Fatty Liver in mice 1.00
Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning 1.00
Visual Whole-Process Monitoring Dynamic Phase Separation of Autophagic Lysosomes in Alzheimer’s Disease by a Lysosome-Targeted pH-Activated Fluorescence Probe 1.00
Developing Quinacridone-Based Long Fluorescent Lifetime Probes for Cell Membrane Heterogeneity Imaging 1.00
Oligomerization Propensity Governs Self-Assembly Morphology: Insights from Steady-State Oligomer Analysis 1.00
Simultaneous Monitoring of Intracellular Glucose and Extracellular Lactate in Single Cells to Assess Cell Tumorigenicity 1.00
Stretchable Sensor-Integrated Microfluidic Chip for Monitoring Fatty Acid-Enhanced Serotonin Release from the Intestinal Epithelium 1.00
Tris(2,2′-bipyridyl)ruthenium(II) Electrochemiluminescence of Sugar Alcohols 1.00
Deciphering Spatiotemporal Control of Ferroptosis in HCC: A Bifunctional Probe for Lipid Droplet Viscosity Dynamics and Interorganelle Communication 1.00
Construction of High-Performance Wash-Free Aβ Probes Based on Amino Group Optimization and Amphiphilic Molecular Engineering Strategies 1.00
Decreased Lysosomal Polarity during Acute Alcoholic Liver Injury Revealed by a Near-Infrared Fluorescent Probe 1.00
Multilevel Hydrangea-like Heterogeneous Oxides Enabling COVID-19 Progression Surveillance via Metabolic Fingerprints 1.00
Cascade DNA Logic Strategy for Profiling the MiRNA-210-Targeted Signaling Pathway in the Warburg Effect of Triple-Negative Breast Cancer 1.00
Near-Infrared Room-Temperature Phosphorescent Organic Nanoparticles for Amyloid-β Targeting and Time-Resolved Imaging 1.00
Real-Time Analysis of the Biomolecular Interaction between C1q and Amyloid-β Protein by Dual Polarization Interferometry 1.00
Resolving Phospholipid-Molecule Mobility and DNA-Mediated Combinatorial Fusion for a Single Nanoliposome by Plasmonic Imaging 1.00
Super-Resolution FLIM Imaging of Intracellular Lipid Microenvironments with a Dual-Responsive Polarity- and pH-Sensitive Fluorescent Probe 0.88
Rational Design of Long-Circulating Bright Fluorescent Probe for In Vivo Imaging of Amyloid-β Plaques in Alzheimer’s Disease 1.00
1 1.00
Efficacy and safety of preemptive magnesium sulfate infusion during pheochromocytoma and paraganglioma resection: a randomized, double-blind, placebo-controlled trial. 1.00
5 5.00
Oxidative Damage Fine‐Tunes G‐Quadruplex Structures in Human Gene Promoters 1.00
Chiral Discrimination of all Proteinogenic Amino Acid Enantiomers by Nanopore Sensing 1.00
Quantitative Reactivity Profiling of Functional Arginine Residues in Human Cancer Cell Line Proteomes 1.00
Location‐Differentiated DNA Hierarchical Cyclic Construction Demarcating Identical Biomolecules Across Cell Membrane Microenvironments 1.00
Selective Leaflet‐Anchored DNA Nanoprobes for Simultaneous Monitoring of Juxta‐Plasma Membrane Environments 1.00
1 0.79
Bile acids metabolism in symptomatic hand osteoarthritis 0.79
1 0.94
Compensatory roles of STT3A and ALG5 in glucose metabolism of aged macaque hippocampus 0.94
16 13.81
NSD1-Mediated PPARγ Methylation Enhances PTEN Activity to Suppress Glycolysis and Tumor Progression in Endometrial Cancer 1.00
SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance 1.00
Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer 1.00
IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma 1.00
ACSL5 Mediates Adaptation to the Palmitic Acid–Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis 0.93
Long-Chain Fatty Acid Redistribution Induced by SLC27A2 Deficiency Facilitates Hypoxic Adaptation and Immunosuppression in Hepatocellular Carcinoma 1.00
Nutrient Availability Dictates Cancer Metabolism-Based Therapeutic Responses to Non-oncology Drugs. 0.04
A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression 1.00
Targeting the ATM-TGS1-BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma. 0.77
PRMT3 Drives IDO1-Dependent Radioresistance and Immunosuppression by Promoting Kynurenine Metabolism in Non-Small Cell Lung Cancer. 1.00
PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer 0.07
tRF-21LeuTAA Promotes Oxidative Stress by Altering Glutathione Metabolic Enzymes to Support Prostate Cancer Progression. 1.00
Gut Microbiota-Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment. 1.00
Malonyl-CoA Promotes Prostate Cancer Progression and Castration Resistance by Enhancing Lipogenesis and Ran Activation. 1.00
PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis. 1.00
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression 1.00
5 4.91
Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation 1.00
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity 0.94
Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma 0.98
Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline 1.00
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL 1.00
15 13.35
Hyocholic acids shape neonatal immune tolerance and microbiota assembly 1.00
Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes 0.90
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells 0.03
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages 0.94
Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease 1.00
Lipid-induced granules in hepatocytes alleviate liver fibrosis 1.00
Mitochondrial VHL rewires cell metabolism in hypoxia 0.91
The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα 1.00
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis 1.00
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer 1.00
Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation 1.00
Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development 1.00
Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells 1.00
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression 0.85
Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury 0.72
1 1.00
A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression 1.00
2 2.00
Lipid droplet-targeted photosensitizers: emerging strategies for triggering programmed cell death 1.00
Identification and quantification of human serum albumin from different sources by a fluorescence sensor array 1.00
3 3.00
Crosslinker nanocarrier-based intratumoral delivery for protein complex mapping in mitochondria of live tumor-bearing mice 1.00
Thermal-mediated modulation of binary supramolecular self-assembly from phase separation to co-crystallization at the liquid–solid surface 1.00
Thermal proteome profiling of itaconate interactome in macrophages 1.00
1 0.91
SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure 0.91
1 1.00
Altered cortical dynamics and adaptive behavior following early-onset sucrose overconsumption 1.00
2 1.89
Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells 1.00
A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma 0.89
4 4.00
Associations between domestic water hardness and incident type 2 diabetes and the mediating role of metabolomics 1.00
Environmental exposure to bisphenol S suppresses white adipocyte beiging and energy expenditure via CYP2E1 in mice 1.00
Short-term ozone exposure and schizophrenia hospitalization risk: temperature modifying effect and greenspace mitigating effect 1.00
The associations of essential metal elements and their mixture with gallstone disease in Chinese older adults: The mediation role of superoxide dismutase 1.00
2 2.00
Associations of Concomitant Exposure to Outdoor Light at Night, Air Pollution, and Greenness with Metabolic Syndrome: A Cohort Study in China 1.00
Occupational Noise Exposure and ASCVD Risk in Chinese Workers: the Cross-lag Mediating Role of free fatty acids 1.00
3 3.00
Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism 1.00
Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway 1.00
Bis(2-Ethylhexyl)-2,3,4,5-Tetrabromophthalate Promotes NASH Progression through Disrupting Endoplasmic Reticulum-Mitochondria Contacts 1.00
2 2.00
Histamine N-methyltransferase upregulation, cardiac hypertrophy, and heart failure 1.00
Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction 1.00
11 9.04
Tumour-infiltrating adipocyte-derived 12,13-DiHOME subverts CD8+ T cell immunity in pancreatic ductal adenocarcinoma by promoting PPARγ-mediated ferritinophagy and tumour-associated neutrophil ferroptosis 1.00
Blocking MOXD1-derived ACOX1 peroxisome trafficking suppresses metabolic dysfunction-associated steatohepatitis 0.95
Landscape screening identifies the lactate-modifying enzyme AARS2 as a master regulator and therapeutic target in hepatocellular carcinoma 1.00
JOSD1 drives hepatocellular carcinoma malignancy by modulating the ubiquitination-lactylation switch on PGAM1 1.00
Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation 1.00
MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming 1.00
Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement 0.17
PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8+ T cell dysfunction 1.00
Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease 0.91
Discovery of a carboxyl fullerene derivative as a new lipid droplet regulator inhibiting MASLD 1.00
Targeting Treg–fibroblast interaction to enhance immunotherapy in steatotic liver disease-related hepatocellular carcinoma 0.02
4 2.54
Cardiovascular-Kidney-Metabolic syndrome and the risk of liver fibrosis progression and liver-related events in MASLD. 0.23
A novel mechanism involving USP53-regulated BSEP trafficking underlies low-GGT intrahepatic cholestasis. 0.94
MIF-mediated crosstalk between THRSP+ hepatocytes and CD74+ lipid-associated macrophages in hepatic periportal zone drives MASH. 1.00
Type 2 Diabetes mellitus as an independent predictor of significant fibrosis in treatment-naïve chronic hepatitis B patients with concurrent hepatic steatosis. 0.36
2 2.00
Palmitic acid reprograms neutrophils to compromise vascular integrity and promote breast cancer lung metastasis 1.00
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance 1.00
8 7.93
Gut microbiota alteration contributes to bone marrow mesenchymal stem cells connexin43 response to high-fat diet induced obesity in mice 1.00
Risk factors and clinical nomogram for fatty pancreas in adults with obesity: a case-control study 1.00
Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight 0.93
Brown adipose tissue-derived exosomes ameliorate obesity-related hypertension via HuR-mediated restoration of endothelial function 1.00
Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat 1.00
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling 1.00
Interleukin-33 promotes lipolysis of adipocytes and protects male mice against obesity via activation of β-adrenergic receptor signaling 1.00
Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization 1.00
1 0.27
Sweetened Beverages and Incident All-Cause Dementia Among Older Adults 0.27
16 14.96
Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells 1.00
Phosphatidylinositol 4-kinase α suppresses glioblastoma progression by inactivating YAP and PI3K/Akt signaling 1.00
Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B 1.00
RNF90 promotes hepatic steatosis by degrading CPT1α to suppress fatty acid oxidation 1.00
GPR39 mediated molecular signaling by bile acids 1.00
Hypoxia-Inducible Factor 1αa Regulates Lipid Metabolism to Coordinate Adipocyte Hypertrophy and Hyperplasia in Grass Carp 1.00
HDAC6-mediated PFKL deacetylation enhances aerobic glycolysis and promotes VSMC proliferation 1.00
Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation 0.88
CircAMOTL1 promotes adipose lipolysis and browning in cancer cachexia through miR-211-5p-mediated TET2 activation 1.00
Histone deacetylase HDA-5 regulates lipid metabolism through H4K5 and H4K8 acetylation in Caenorhabditis elegans 1.00
YAP-mediated glycolysis promotes pulmonary arterial smooth muscle cells proliferation in pulmonary arterial hypertension 1.00
RNase P generated tRFSer-GCT promotes fat storage in adipocytes via Adrb2 signaling 1.00
β-hydroxybutyrate dehydrogenase promotes pancreatic cancer cell proliferation through regulation of the NAD+/NADH balance and mitochondrial acetylation 1.00
Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis 1.00
Quantification profiles of enzyme activity, secretion, and psychosine levels of Krabbe disease galactosylceramidase missense variants 0.14
Endocytosis of sialic acid Neu5Gc and elevated p53 contributes to preimplantation embryonic arrest during in vitro fertilization 0.94
4 4.00
NRZ complex facilitates virus infection via enhancing ER–LD contacts 1.00
In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice 1.00
Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation 1.00
ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13 1.00
1 0.75
Tracing calcium flows for bulk calcium waste management in China 0.75
11 7.55
Metabolic dysfunction-associated steatohepatitis exacerbated by Clostridium perfringens-derived ammonia is attenuated by tripeptide DT-109 0.82
α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models 1.00
Biallelic GLTP mutations cause nonsyndromic epidermal differentiation disorder via disrupted epidermal glucosylceramide transport 0.73
Notch1 O-GlcNAcylation drives tumor stemness and mechanoadaptation to a stiff microenvironment and promotes chordoma recurrence 1.00
Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1 1.00
Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression 0.88
Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche 1.00
GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs 0.04
Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction–associated steatohepatitis 0.97
SPNS1 variants cause multi-organ disease and implicate lysophospholipid transport as critical for mTOR-regulated lipid homeostasis 0.02
Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice 0.10
5 5.00
Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity 1.00
Activated hepatic stellate cells maintain liver bile acid homeostasis through paracrine FGF10/FGFR2 signaling 1.00
AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC Effect of the BA/Butyrate/CXCL14 axis in HCC 1.00
S1P/S1PR4 Promotes the Differentiation of CD8+ tissue-resident memory T Cells Aggravating Bile Duct Injury in Biliary Atresia 1.00
Decreased LONP1 expression exacerbates MASH-induced liver fibrosis via elevated orotic acid levels 1.00
9 6.43
Tyr39 Phosphorylation of α-Synuclein Accelerates Heterotypic Aggregation and Drives Toxic Amplification 1.00
A Scalable COF-Based Sequestrant for Synergistic Bile Acid Modulation in Fatty Liver Disease 1.00
Probing the Conformation of BamC and BamE in Native Bacterial Membranes Using Solid-State NMR Spectroscopy 0.17
Secondary Structure-Encoded Control of Lipid Assembly by Radially Amphiphilic Peptides 1.00
Bifunctional LYTAC Mediates Hepatocytes-Hepatic Stellate Cells Crosstalk by Regulating 5-HT2A Receptor Degradation and Antagonism to Synergistically Ameliorate Hepatic Fibrosis 1.00
Construct Open Lipid Nano-Membranes with Controllable Lateral Behavior 1.00
Synthesis of Crystalline Calcium Bicarbonate 1.00
Strain-Distinct α-Synuclein and Tau Cross-Seeding Uncovered by Correlative Approach with Optical Photothermal Infrared Sub-Micron Imaging 0.21
Organic Carbon Monoxide Prodrugs Activated by Endogenous Reactive Oxygen Species for Targeted Delivery 0.05
7 6.79
S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis 1.00
Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1 0.92
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer 0.88
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer 1.00
UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance 1.00
A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response 1.00
Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer 1.00
2 2.00
Hyperbranched Poly(citric acid) Mitigated Iron Overload Damage via Iron Chelation and Antioxidation 1.00
Visual Diagnostic Strategy for Assessing the Impact of Aerobic Glycolytic Processes on Tumor Growth and Therapy 1.00
8 3.32
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation 0.01
A deep-learning framework reveals whole-body perturbations at cell level 0.01
Proteasome-guided haem signalling axis contributes to T cell exhaustion 0.25
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis 1.00
RYK is a GPNMB receptor that drives MASH 1.00
Structure and mechanism of the human bile acid transporter OSTα–OSTβ 1.00
Nutrient requirements of organ-specific metastasis in breast cancer 0.03
Genetic suppression features as a Barth syndrome therapeutic target 0.02
1 0.91
Sustained nitric oxide production by engineered remodels the tumor microenvironment and potentiates immunotherapy 0.91
3 2.79
Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma 0.79
Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity 1.00
Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells 1.00
5 4.06
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line 1.00
GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression 0.87
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells 0.19
α-Ketoglutarate dictates AMPK protein synthesis for energy sensing in human cancers 1.00
Unraveling Alzheimer’s complexity with a distinct Aβ42 fibril type and specific AV-45 binding 1.00
84 75.94
Inference of upstream-mutation and metabolomic-signature causality identifies prognostic biomarkers and therapeutic targets in pancreatic cancer 1.00
Metabolic characterization of the tumor microenvironment orchestrates therapeutic strategies and clinical outcomes in pancreatic cancer 1.00
An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer 0.93
Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH 0.21
C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice 1.00
Macrophage ALDH2 drives immunotherapy resistance by silencing CXCL9 through metabolic-epigenetic crosstalk 1.00
Oxysterol undersulfation promotes osteoarthritis by fueling chondrocyte lipid accumulation 1.00
Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis 0.75
A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis 1.00
The SIRT3-DsbA-L-TFAM axis restrains cGAS-driven metabolic dysfunction-associated steatohepatitis in male mice 0.54
Enzyme-centric chemoproteomics reveals isomer-specific S-acylation modification networks 1.00
EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling 1.00
White adipose atrophy exacerbates cold stress and accelerates aging in male mice 0.94
Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5 0.21
Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepatic steatosis in high fat diet-fed male mice 1.00
Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice 1.00
Inhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer 0.93
YY1/Asprosin/PFKP axis regulates glycolytic metabolic and exacerbates pathological cardiac hypertrophy 1.00
Structural and functional dissection of a higher-order oligomerization interface in yeast ceramide synthase 1.00
Lactylation at lysine 145 fosters KAT8-TIP60 complex formation to promote p53 acetylation at lysine 120 and its pro-apoptotic function 1.00
Regulation of physical activity and energy expenditure through Phf6 in the medial preoptic area 1.00
Pentose phosphate pathway fuels cGAS-STING signalling to boost function of intratumoral conventional dendritic cells 1.00
Structural mechanism of substrate binding and inhibition of human taurine transporter 1.00
NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift 0.07
INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesis 1.00
Hepatocyte SLCO4C1 is a cAMP uptake transporter for inhibiting lipogenesis and a therapeutic target for MASLD 0.90
Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma 1.00
Embryo metabolite analysis and implantation potential prediction using chemiluminescent microfluidic chips with dielectric wetting valves 1.00
Diverse regulation of functional dimerization of a sugar transporter by different interfacial lipids 0.89
-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1 1.00
Phosphoglycerate dehydrogenase-mediated serine reprogramming aggravates macrophage hyperinflammation in murine pneumonia 1.00
Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner 1.00
TGFβ-activated PDHB promotes mitochondrial pyruvate metabolism and contributes to human endoderm differentiation via ATP-dependent BRG1 1.00
GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesis 1.00
MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease 0.79
Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression 1.00
Interleukin-10 expressing B lineage cells in visceral adipose tissue protect against aging-related insulin resistance and extend lifespan 1.00
1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis 1.00
Sugar rationing during the first 1000 days of life and lifelong risk of heart failure 1.00
The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis 1.00
Palmitic acid-triggered B7H3 palmitoylation promotes immune escape 1.00
Improving erectile function in diabetic male mice by rescuing depalmitoylated FBP1 to reduce cavernosal lactate 1.00
Adipocytic sclerostin loop3-LRP4 interaction required by sclerostin to impair whole-body lipid and glucose metabolism 1.00
Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis 0.20
Amyloid-ID: photocatalytic profiling of amyloid deposits in Alzheimer’s disease tissue 1.00
Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma 0.46
Systemic engineering and global regulation enabling high-level bilirubin biosynthesis 0.88
Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential 1.00
Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer 1.00
Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis 1.00
Sequestration of the phagocyte metabolite itaconate by Pseudomonas aeruginosa RpoN promotes successful pulmonary infection 0.12
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD 1.00
Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation 1.00
Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway 0.86
Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment 0.95
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity 1.00
Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets 1.00
Desat1-mediated lipid homeostasis mitigates 20E-induced lipotoxicity in blood-fed mosquitoes 1.00
The E3 ligase tripartite motif 7 drives the progression of non-alcoholic fatty liver disease by targeting DUSP10 degradation in male mice 1.00
The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility 1.00
Atomic structure and in situ visualization of native PMEL lamellae in melanosomes 1.00
MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution 0.50
A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation 1.00
A preserved TGFβ cytostatic response through DLD-mediated metabolic modulation undermines anti-TGFβ therapy in gastric cancer 1.00
The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer 1.00
Targeting phagocytosis for amyloid-β clearance: implications of morphology remodeling and microglia activation probed by bifunctional chimaeras 1.00
Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming 1.00
Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk 1.00
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease 0.71
Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis 1.00
Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing mRNA 1.00
Molecular basis of human taurine transporter uptake and inhibition 1.00
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth 1.00
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure 0.11
A genetically encoded biosensor for point-of-care and live-cell detection of -2-hydroxyglutarate 1.00
PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate 1.00
PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning 1.00
β-Hydroxybutyrate promotes cancer metastasis through β-hydroxybutyrylation-dependent stabilization of Snail 1.00
Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice 1.00
Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism 1.00
Dimerization and substrate recognition of human taurine transporter 1.00
Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging 1.00
Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling 1.00
Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling 1.00
3 1.67
Early methionine availability attenuates T cell exhaustion 0.03
LARP4-mediated hypertranslation drives T cell dysfunction in tumors 0.64
Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment 1.00
1 0.05
Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis 0.05
2 2.00
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice 1.00
Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca-mediated increases in astrocytic cholesterol 1.00
3 2.00
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity 0.13
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms 0.87
PEX14 condensates recruit receptor and cargo pairs for peroxisomal protein import 1.00
4 3.81
Hyperexcitable VTA-mPFC dopaminergic circuit disrupts sleep spindle and mediates sleep fragmentation after chronic social defeat stress 1.00
Hepatic expression of APOE3 Christchurch mitigates APOE4-related Alzheimer’s disease pathologies in mice 1.00
Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis 0.81
Reversal of diet-induced obesity by central insulin sensitizer FSTL1 1.00
1 1.00
Peptide-Compatible Photoredox-Catalyzed Mutagenesis of Dehydroalanine to Aspartic Acid 1.00
3 2.90
The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target 1.00
USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice 1.00
Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity 0.90
2 1.07
Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations 0.07
A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat 1.00
18 15.26
Akkermansia muciniphila–derived L-norleucine modulates FABP1-dependent fatty acid transport 1.00
Lactylated NAT10 contributes to elesclomol-triggered cuproptosis via the NAT10/ac4C-DLAT-mRNA/DLAT positive feedback loop in CRC 1.00
Cellular Feimin promotes cold-induced thermogenesis 1.00
Lipid metabolism in adipocytes modulates tumor growth at a distance through Nplp2-mediated Wnt5 signal 1.00
Structural studies of an antinecroptosis viral:human functional heteroamyloid M45:RIPK3 using SSNMR 0.12
Reconstruction of human metabolic models with large language models 0.36
PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment 1.00
Phase separation of DDHD2 remodels lipid metabolism to dictate treatment sensitivity in luminal breast cancer 1.00
D-amino acid aminotransferase1 regulates grain chalkiness in rice by modulating endoplasmic reticulum stress response 1.00
Nonoxidative pentose phosphate pathway regulates CD8+ T cell immunity by maintaining NADPH homeostasis 1.00
Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning 1.00
Long-chain unsaturated free fatty acids control gut motility via nitrergic ganglia of the enteric nervous system 1.00
A viral Cyclin D homolog protein hijacks the metabolic stress sensor SESN2 to promote primary effusion lymphoma growth 1.00
Intercellular propagation of RIPK1/RIPK3 amyloid fibrils 1.00
CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis 0.20
OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation 0.88
PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis 0.71
UFMylation: A supervisor of the HIF1α pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors 1.00
2 2.00
J-Editing Proton MR Spectroscopy for Brain Signal Separation in Methylmalonic Acidemia: A Pediatric Case-Control Study. 1.00
Association of Body Fat Distribution Patterns at MRI with Brain Structure, Cognition, and Neurologic Diseases. 1.00
1 0.34
Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential 0.34
14 9.87
PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function 0.92
d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation 1.00
SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth 1.00
Clinically relevant stereochemistry reprograms amyloid proteome for aggregation cross-talk–conferred neuroprotection 1.00
Elovl6 inhibits colorectal cancer progression through stearic acid–mediated mitochondrial fusion and metabolic reprogramming 1.00
Lactate derived from cancer-associated fibroblasts promotes alternative splicing and castration resistance in prostate cancer 1.00
Crotonate suppresses breast cancer metastasis and promotes immunotherapy response by inducing ACSS2-mediated EZH2-K348 crotonylation 1.00
ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness 0.02
Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer 0.75
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH 0.07
Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM 0.05
ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription 0.86
Role of d-serine in intestinal ROS accumulation after sleep deprivation 1.00
The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response 0.20
3 2.87
Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD 1.00
HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells 0.87
AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models 1.00
1 0.50
Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes: natural experiment study 0.50
5 4.89
Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells 0.89
Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export 1.00
C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria 1.00
Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction. 1.00
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ 1.00
2 2.00
In Situ Probing the Effects of Lipid Packing Density and Concentration of CPPs on the Transmembrane Process at the Air–Water Interface 1.00
Steric Control of Copper(II) Coordination by Carnosine: Role of the β-Alanyl Methylene Spacer 1.00
1 0.14
Weight trajectories and access to weight management services in individuals with severe mental illness in the UK: a population-based, matched cohort study 0.14

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