Medical Biotechnology articles for Canada

Time frame: 1 June 2025 - 30 May 2026

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Count: 96

Article ‘Count’ for Medical Biotechnology.

Journal Count Share
3 2.05
Single-Particle Multiparametric Microscopy Reveals Structural, Size, and Payload Heterogeneity in mRNA-Loaded Lipid Nanoparticles 0.97
A Machine Learning Assisted Tool and Numerical Model for Analyzing Lipid Nanoparticles 1.00
Mechanically Matched Heart-on-a-Chip Platform Mediated Maturation of Excitation–Contraction Coupling 0.08
8 7.25
A bioengineered recombinant spider silk provides targeted G-protein-coupled receptor activation 1.00
The influence of scaffold fibre architecture on tenocyte tissue production under intermittent dynamic culture 1.00
Co-delivery of human adipose-derived stromal cells and endothelial colony-forming cells in cell-assembled decellularized adipose tissue scaffolds for applications in soft tissue regeneration 1.00
Smooth muscle cell-like support cells accelerate the autologous endothelialization of a polyurethane scaffold for vascular engineering 1.00
Design and evaluation of cationic bottlebrush polymers for advanced messenger RNA therapeutics 1.00
Characterization of Stability and Shell Elasticity of Monodisperse Microbubbles with Different Pegylated-lipid Content using Pressure-Dependent Attenuation Spectra 0.25
Muscle-specific acellular ECM fibers made with anchored cell sheet engineering support regeneration in rat models of volumetric muscle loss 1.00
Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells 1.00
6 2.92
VIVID: A qPCR-Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles 1.00
Biomimetic Woven Bone Organoids with Multifocal Centers for Retaining Stemness and Prolonging Osteogenic Activity 0.17
Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo 1.00
Poly(lactic-co-glycolic acid) Nanoparticles for IL-12 Self-Amplifying RNA Delivery in Glioblastoma Models 0.25
High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation 0.39
Simple Zinc Metallic Particle Doping Transforms Ceramic Bone Cement Therapeutic Performance 0.11
2 0.69
Anti-RANKL improves muscle dysfunction and strengthens bone in laminin-α2-deficient dy2J/dy2J dystrophic mice. 0.63
Targeting Skeletal Muscle in Duchenne Muscular Dystrophy: Integrating In-Silico and Experimental Approaches to SGLT2 Inhibition 0.07
18 9.90
Direct Counting of mRNA Copies Inside Individual Lipid Nanoparticles Using In Situ Lysis and Labeling 0.95
Selection of Aptamers To Detect Lean Meat Agents: Ractopamine and Clenbuterol 0.83
Cumulative Spectroscopic Detection for Taylor Dispersion Analysis of Nanoparticles 0.20
Engineering High-Performance Aptamers via Optimized SELEX and Structure-Guided Dimer Assembly for Clinical Malaria Diagnostics 0.56
High-Affinity Three-Way Junction Aptamers for Sensing Cationic Polymyxin Antibiotics 0.50
d-Lactate SELEX Yielding Aptamers Binding Stronger to l-Lactate: Implication of Intrinsic Chiral Preference 1.00
Catalytic Amplification-Mediated Single-Nanotag Assembly for Sensitive Detection of Circulating microRNAs 0.14
Simultaneous Detection of SARS-CoV-2 Nucleocapsid Protein and RNA by Aptamer-Based Proximity Ligation and Quantitative PCR 1.00
A Microfluidic Colorimetric Biosensor Integrated with Water-Soluble Nonwoven Fabrics for Collection and Detection of Bacterial Aerosols 0.09
Wearable Fingernail-Based Microfluidic Paper Analytical Device for Naked-Eye Detection of γ-Hydroxybutyric Acid in Beverages 0.17
Clicking Fluorometric Probes on Micropatterned Glass Microfiber Filters for ppb-Level Copper Quantitation 0.89
Field-Deployable Immuno-Solid-Phase Microextraction Coupled with Photothermal Imaging for Rapid Pathogen Surveillance in Environmental and Clinical Matrices 0.14
Thioflavin T Is a More General and Less Interfering Probe for Aptamer Binding Assays Than SYBR Green I 0.83
Metabolite Fusion between Breath and Blood Enables More In-Depth Understanding of the Endogenous Metabolome 0.09
EDTA-Masked Tl+ Detection Using a Pair of Non-G-Quadruplex Aptamers with Opposite Fluorescence Responses 0.50
Direct, Selective, and Rapid Measurement of HCN at Sub-ppb Levels Using HiT-CD-IMS: Applications to Cell Culture and Breath Analysis 0.70
A Real-Time Enzyme-Linked Aptamer Assay (RT-eELAA) for Rapid and Sensitive Detection of Viral Antigens in Saliva Using Electrochemical Readout 1.00
Microarray-Based Nanoextraction Combined with Ambient Ionization Mass Spectrometry for Analysis of Drugs of Abuse in Wastewater 0.30
8 7.46
A Portable Colorimetric Device for Rapid Bacterial Detection with Cleavable Functional Nucleic Acid Probes for A Common Bacterial Endoribonuclease 0.77
A Real‐Time Antifouling Multivalent Aptamer Platform for Wash‐Free Electrochemical Detection of Low‐Abundance Biomarkers in Human Plasma 0.94
Transforming RNA Degradation into Accurate RNA Detection: RNase I–Assisted Rolling Circle Amplification for Clinical Samples 1.00
Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand-Displacement Reaction 1.00
Green Fluorescent Protein SELEX: Immobilization Chemistry and His‐Tag Epitope Bias 1.00
Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions 0.75
Enhancing Clinical Detection Accuracy of Large Structured Viral RNA via DNAzyme Cleavage and Antisense‐Assisted Rolling Circle Amplification 1.00
A Combined Aptamer Pulldown‐DNAzyme Cleavage Assay for Intact Methicillin Resistant iStaphylococcus aureus/i Cells 1.00
1 0.05
Marstacimab Prophylaxis in Hemophilia A/B Without Inhibitors: Results from the Phase 3 BASIS Trial 0.05
2 0.58
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum 0.58
Deciphering iDST/i-associated disorders: biallelic variants affecting DST-b cause a congenital myopathy 0.01
1 0.83
Combining aptamers for thiamphenicol and chloramphenicol for detecting both antibiotics 0.83
2 1.48
A high-affinity dopamine aptamer: implications of library diversity and negative selection 0.83
A general transition metal binding aptamer following the Irving–Williams series 0.64
1 0.14
Cost-effectiveness of Targeted Next-Generation Sequencing for Tuberculosis Drug-resistance Testing as an Alternative to the Standard of Care in South Africa 0.14
1 1.00
Immunomodulatory effects of Tritan copolyester on human neutrophils 1.00
1 0.07
Bezeotermin Alfa (rhBMP-6) Administration in Lumbar Interbody Fusion Surgery Using a Posterior Approach 0.07
1 1.00
Muscle derived BMP4 regulates morphology and function of endplates on extrafusal and intrafusal muscle fibers in adult mice 1.00
2 1.04
Autonomous Exponential Amplification via Rolling Circle–DNAzyme Feedback Programming 0.14
Baited SELEX: Drug-Directed Selection of Aptamers to PSMA for In Vivo Targeting of Prostate Cancer Xenografts in Mice 0.89
1 0.04
Diagnostic performance of Alzheimer’s disease blood and CSF biomarkers in a Brazilian cohort with low educational attainment 0.04
2 1.68
Multiparametric Characterization of Individual Suspended Nanoparticles Using Confocal Fluorescence and Interferometric Scattering Microscopy with Microfluidic Confinement 0.93
A Hybrid Molecule/Graphene van der Waals Heterostructure for DNA Immobilization and Detection 0.75
1 1.00
A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery 1.00
11 7.08
GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy 0.00
Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components 1.00
Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors 0.77
Histidine-rich coiled-coils promote zinc-dependent self-assembly and curing of porous mussel glues 0.56
Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model 0.05
A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines 0.93
Revealing heterogeneity and damage response in the adult human utricle 0.89
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells 0.78
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis 1.00
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics 0.10
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration 1.00
1 0.83
Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung 0.83
1 0.01
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology 0.01
3 1.21
Ultra-rapid nanoplasmonic colorimetry in microfluidics for antimicrobial susceptibility testing directly from specimens 1.00
Designing lipid nanoparticles using a transformer-based neural network 0.06
Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications 0.14
1 0.88
The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice 0.88
4 2.16
TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15 0.26
ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal 1.00
Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy 0.78
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo 0.13
1 0.03
B lymphocyte protein factories produced by hematopoietic stem cell gene editing 0.03
2 0.30
Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle–mediated infection in humanized liver chimeric mouse models 0.21
Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity 0.08
2 0.05
Overall survival with relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): a phase 3 randomised controlled trial 0.02
Relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial 0.02
1 0.15
Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial 0.15
2 0.37
Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study 0.04
Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis 0.33
1 0.29
Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial 0.29
4 0.85
Mim8 Bispecific Antibody Prophylaxis in Hemophilia A with or without Inhibitors 0.07
Adenoviral Inciting Antigen and Somatic Hypermutation in VITT 0.05
Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk 0.03
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia 0.70
1 1.00
Benchmarking a massively parallel nucleic acid hybridization platform for monitoring biomarkers of public health significance in wastewater 1.00

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