Medical Biotechnology articles for Chinese Academy of Sciences (CAS), China

Time frame: 1 June 2025 - 30 May 2026

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Count: 198

Article ‘Count’ for Medical Biotechnology.

Journal Count Share
20 5.90
Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment 0.08
A Hybrid Phospholipid Monolayer-Based Interface for Interaction-Enhanced Electrical Detection in Biofluids 0.03
Triple-Cascade Responsive Pneumatic Nanomotor Enhance Cancer Immunotherapy by Oncolytic Virus-Triggered Pyroptosis 0.06
Aptamer-Driven DNA Framework Switches for Clearing Programmed Cell Death-Ligand 1 Positive Extracellular Vesicles via Macrophage Recruitment 0.30
Mucosal-Penetrating Nanovaccine Enhances Mucosal and Systemic Immunity against Respiratory Syncytial Virus Infection 0.15
Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects 0.07
Ultrasound-Triggered Charge-Reversal Nanoparticles via Golgi-Dependent Iterative Transcytosis for Enhanced Deep Tumor Penetration 0.57
Self-Carrier Nanoagonist Enabling Positive Feedback Regulation of Cuproptosis-Immunity for Potent Antitumor Therapy 0.39
Shape-Dependent Entropic Forces Govern Synergistic Bystander Nanoparticle Uptake 0.50
Bioactive Multifunctional Hydrogel Scaffolds Remodel the Inflammatory Microenvironment and Osteogenic-Osteoclastic Homeostasis to Advance Osteoporotic Bone Defect Repair 0.22
Spatial Lipid Metabolic Remodeling from Placenta to Multiple Suborgans during the Gestational Micro- or Nanoplastics Exposure 0.33
Orbital Hybridized MoO3/MoSe2 Heterojunction for Dual-Driven Interfacial Reaction and Charge Transfer Toward Enhanced Electrochemical Response 0.08
Disulfide-Appended siRNA Nanoeyedrops: Noninvasive Gene Therapy for Targeting Retinal Angiogenesis 0.04
Mass-Ratio-Controlled Organ-Selective Phosphatidyl Polymer Carrier for In Vivo Targeted mRNA Delivery 0.65
Intelligent Responsive Zeolitic Imidazolate Framework-8@Copper Oxide Nanocomposite 3D-Printed Scaffolds for Efficient Repair of Infected Bone Defects 0.10
Fenton Reaction-Mediated Endolysosomal Disruption for Efficient Cytosolic Protein Delivery 1.00
Mechanically Matched Heart-on-a-Chip Platform Mediated Maturation of Excitation–Contraction Coupling 0.08
Differential Mapping of Intracellular Metallic Nanoparticles and Ions and Dynamic Modeling Prediction 0.05
Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing 0.40
Virus-like Nanoparticles Deliver Small Interfering RNA to Pancreatic Cancer Cells through Filopodia-Mediated Internalization 0.79
18 4.47
Temporally Programmed Multifunctional Hydrogel Dressings for Optimized Wound Healing and Symptom Relief 0.54
ROS-Responsive Microneedles Loaded With Biomimetic Nanozymes for Rotator Cuff Repair and Adipose Infiltration Prevention 0.03
An Engineered E. Coli-Based Living Material Platform for Protease Biosensing 0.33
Synergistic Piezoelectricity and Lubrication in an Injectable Hydrogel for Osteochondral Regeneration 0.10
Microenvironment-Responsive Nanozyme for all Stages of Infectious Chronic Wound Management through Macrophage Reprogramming 0.03
Bioengineered CBD‐hBD‐3 Fusion Peptide‐Functionalized Collagen Scaffold Reprograms Fibroblast Fate to Attenuate Fibrosis and Promote Multilayer Vaginal Regeneration 0.77
Noninvasive, Electro‐Boosted Catalytic Anti‐Inflammation System for on‐Demand Osteoarthritis Treatment 0.69
A Thermoplastic and Visualizable Bone Scaffold Dynamically Enhances Hemostasis and Osteogenesis in Bone Defects 0.13
3D‐Printed StrontiumSilicate Hydrogel Scaffold Promotes Sensory Innervation and Tissue Regeneration Through Modulating Macrophage Senescence 0.07
Bioinspired Hydrogel Prepared by Core-Shell Nanofibers: Accelerating Wound Healing via Macrophage Polarization Modulation 0.64
Fluorescence/Colorimetric Lateral Flow Immunoassay Based on Dual-Aptamer Domain Recognition and Upconversion Signal Amplification for Sensitive H1N1 Hemagglutinin Detection 0.05
Engineered Poly(ethylene glycol)‐Alendronate‐Magnesium Hydrogels Potentiate Site‐Specific Immunomodulation for the Healing of Osteoporosis Fractures 0.09
Dual-Network Bioactive Implant Promotes Weight-Bearing Bone Healing via Mechano-Bioelectric Coupling 0.20
Bioinspired Alginate/α-TCP Organic–Inorganic Interpenetrating Network Microspheres for Bone Repair 0.13
Biodegradable Dual-Stimuli Hydrogel Scaffoldoid Synergizing Piezoionic and Lithium-Ion Release for Critical-Sized Bone Defect Regeneration 0.32
Biodegradable Polymeric Nanoparticle Employing a Photodynamic/Photothermal/Thermodynamic Combination Strategy for Treatment of Acute Maxillofacial Wound Infections 0.15
The Rational Design of Pt Single Atoms‐Bridged Nanozyme with Enhancing Direct Electron Transfer Pathway for Glucose Oxidation 0.13
Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction 0.08
20 5.18
A Dual-Targeting Strategy Against ROS and GSK-3β With a PEGylated Fullerene/Smart Hydrogel Synergistic System for Diabetic Bone Regeneration 0.25
N-Acetylcysteine–Mediated Surface Remodeling of Inhaled mRNA Lipid Nanoparticles Enables Coordinated Mucosal and Systemic Antitumor Immunity 0.33
Sea Urchin‐Inspired Immuno‐Instructive Ionic Flow Drives MSCs‐Macrophage Communication to Promote Bone Regeneration 0.17
A Structurally Stabilized Lipopolymer Nanoplatform Targeting Pan‐Tissue Antigen‐Presenting Cells Enables Durable in situ mRNA Cancer Immunotherapy 0.17
Photosynthetic Nanobacteria Drive Metabolic-Immune Synergy for Hypoxia-Resistant Cancer Therapy 0.25
Unlocking an Efficient SOD-to-CAT Catalytic Relay in a MOF Nanozyme via Dopamine-Driven Interfacial Nanoreconstruction for Osteoarthritis Therapy 0.15
Micropore‐Confined ROS‐Responsive 3D‐Printed Shell‐Core Scaffolds for Long‐Term NO Release to Orchestrate Immunomodulation and Angiogenesis in Diabetic Bone Defect Repair 0.17
Trace Detection of Multiple Macromolecular Biomarkers in Saliva by Enzymatic Responsive Serial‐Nanofluids Strategy 0.33
DNA Supramolecular Hydrogel Alters Exosomal microRNA Atlas and Paracrine Secretory Profile of MSCs to Promote Bone Remodeling and Ameliorate Osteoradionecrosis of the Jaw 0.11
Fusion Peptide-Incorporated Lipid Nanoparticles Boost Endosomal Escape and Enhance Cytosolic mRNA Delivery 0.37
Engineering Asymmetric and Highly Exposed Fe Single‐Atom Nanozymes for siMMP13 Delivery and Ferroptosis Inhibition in Osteoarthritis Therapy 0.03
Optimizing Peptide Ionizable Lipids Enables Efficient and Low-Toxicity mRNA Delivery for In Vivo Prime Editing and Protein Replacement Therapy 0.47
Endogenous Metal Ion‐Enriched Immunostimulating Biomimetic Scaffold Improves In Situ Bone Regeneration 0.06
Akkermansia Muciniphila-Inspired Oral siRNA Delivery by Active Matrix-Penetration and Intracellular Endoplasmic Reticulum Accumulation 0.39
Resolving the mRNA Encapsulation‐Release Trade‐off via Compensatory Forces in Engineered Ionizable Lipids 0.43
Modular Assembly of Lipid Nanoparticles for Targeted mRNA Therapeutics and Vaccines 0.32
Construction of Diverse Calcium-Based Nanomaterials through a Microemulsion Method for Pyroptosis-Initiated Antitumor Immunotherapy 0.53
Calcium Phosphate Nanoparticle-Immobilized Macrophage-Derived Extracellular Vesicle Nanohybrid Facilitates Diabetic Bone Regeneration 0.06
Temporal Immunomodulatory Hydrogel Regulating the Immune-Osteogenic Cascade for Infected Bone Defects Regeneration 0.18
Piezoelectric Injectable Anti‐Adhesive Hydrogel to Promote Endogenous Healing of Tendon Injuries 0.41
41 14.13
Real-Time Label-Free Monitoring of Nanoparticle–Cell Interactions in Single Tetrahymena thermophila by Mass Cytometry 0.48
Discovery of NMP22-Targeting Aptamers for Point-of-Need Test of Bladder Cancer 0.39
Dual-Competitive Turn-On SERS-Lateral Flow Immunoassay for Ultrasensitive Cortisol Detection in Saliva 0.75
Rapid and Accurate Diagnosis of Bacterial Infections via Profiling of Metabolic Volatile Organic Compounds Using Proton Transfer Reaction Mass Spectrometry 0.77
Label-Free Electrochemiluminescence Detection of Urinary AD7c-NTP Using Structurally Optimized Iridium(III) Complexes on Boron-Doped Diamond Electrodes 0.13
Integrated Microfluidic SERS Sensor Featuring Au NPs@Cu MOF/Hydrogel for Label-Free and Specific Creatinine Detection 0.48
Single-Cell Analysis of Zinc Ions During Electrical Stimulation-Induced Pyroptosis by DNAzyme-Functionalized Glass Nanopipettes 0.44
Site-Specific Evolution of DNA Aptamers to Detect ADAR1p150 in Complex Biological Samples 0.36
Electrochemiluminescence Biosensing Platform Based on CRISPR/Cas12a and DNA Nanotweezer-Mediated Catalytic Hairpin Assembly Amplification 0.33
TOI-IGRA: A Fingertip Blood Biosensing Technology for Decentralized Quantification of Pathogen-Specific T-Cell Responses 0.16
Rigid Restriction-Enabled Ultrabright Luminescence through Feather-like Metal-AIEgens Frameworks and Coupling the Collaborative Interfacial Recognition Mechanism for Pathogen Diagnosis 0.10
Breathomics-Guided Solid-State Sensor for Noninvasive Point-of-Care Diabetes Screening 0.33
Bridging Target Recognition with Direct Molecular Counting: A DNA Framework Converter-Mediated nFCM Assay Platform for Quantifying Diverse Biochemical Analytes 0.79
Atomic Fe-Centered Hemin–TiO2 Graphdiyne Nanozyme Sensor for Colorimetric Fingerprinting of Bacterial Extracellular Vesicles 0.10
Real-Time Acoustic Spectroscopy of Nanoparticle Sedimentation in Microfluidic Systems Using Phononic Crystal-Based Ultrasonic Interferometry 0.03
Aptamer-Mediated Protein Corona In Situ Multiplex Microfluidic Detection for Cancer Diagnosis 0.43
Eutectogel-Based Antifouling Interface: Addressing Sensitivity and Accuracy Challenges in Complex Serum 0.20
Push-Button Microfluidic Platform with Dual-Signal Nanoprobes for Enhanced Sensitivity Detection of Healthcare-Associated Infection Pathogens at Point-of-Care 0.83
Quantification of Hydrogen Sulfide in Single Living Cells by Azido-Functionalized Glass Nanopores 0.21
Self-powered Photoelectrochromic Biosensor for Visual Detection Using a Distance-Based Signal Readout 0.14
Dual-Mode Lateral Flow Assay for Simultaneous Quantification of Antibiotic and Bacteria 0.21
Controlled Nanozyme-Substrate Accessibility for Ultrasensitive Electrochemical Detection of miRNA 0.29
An AND-Logic Gate-Based Biosensor for Simultaneous Detection of SARS-CoV-2 Nucleic Acids and Nucleocapsid Proteins 0.56
Novel Ultrafast Sample-to-Answer Microfluidic Platform for Highly Sensitive On-Site Quantification of Avian Influenza Virus 0.57
A Smart Dual-Amplification Electrochemical Analyzer: Product-Activated Tripedal DNA Walker for Glioma Grading 0.08
Catalase-Driven Microflow Displacement for Rapid, Visual Antimicrobial Susceptibility Testing 0.14
Digital-to-Droplet Microfluidic Platform Powered Digital Isothermal Nucleic Acid Amplification for On-Demand Detection of Post-Transplantation Infection-Causing Viruses 0.14
A Pre-Amplification-Free Modular Dual-CRISPR System for Enhanced Pathogen Detection Sensitivity 0.13
Electrochemical Biosensing Platform Based on MOF Carrier Signal Probes and CRISPR/Cas12a Cleavage for Sensitive Detection of MicroRNAs 0.50
Deep Learning-Enabled Real-Time Single-Shot Refocusing of Microwell Array for Digital Melting Curve Analysis 0.79
Field-Deployable Photoelectrochemical Biosensor Using Atomically Defect-Engineered Heterojunction for Ultrasensitive Microcystin-LR Monitoring via Aptamer-Mediated Fe–S Conduction 0.50
Automated Microchannel Resistance Readout of Immunorecognition via Programmable Nuclease Mediation for On-Site Biosensing 0.14
One-Step, Signal-On, and Modification-Free Electrochemical Sensing Platform Based on Aptamer Switch Hydrogel 0.40
Investigation of Characteristic Volatile Organic Compounds in Esophageal Cancer Organoids by Mass Spectrometry 0.50
Novel Self-Powered Biosensor Based on Highly Efficient Cosignal Accelerator and Multiple Signal Amplification Strategies toward Ultrasensitive miRNA-141 Assay 0.02
Benzonase-Based Closed-Tube DNA Degradation Strategy for Elimination of Nucleic Acid Contamination 0.50
Enhancing Classification Robustness in Real-Time Digital PCR via Amplification Curve Regulation and Clustering Analysis 0.62
Selection of Aptamers Targeting Different Epitopes of Recombinant Thyroid-Stimulating Hormone Receptor Protein 0.19
Split G-Quadruplex-Integrated CRISPR-Cas Biosensor for One-Pot, Signal-On Visual Detection of Pathogen Nucleic Acids 0.06
High-Performance Selection of Small-Molecule Nucleic Acid Aptamers and Their Applications 0.26
Property Characterization of Leucine-Integrated Oligonucleotide 0.07
6 2.61
Remote Molecule Activation in Living Mice Triggered by Therapeutic Ultrasound 0.47
Stabilizing Cu3+ Active Center by Intramolecular Electron Transfer for Boosting Complete Glucose Electrooxidation 0.22
Sub‐1 nm CuO‐Phosphomolybdic Acid Nanosheets for Ultrasound‐Controlled Pyroptosis Activation and Tumor Immunotherapy 0.60
Stimuli‐Responsive Catenane‐Branched Dendrimers with Tunable Dimension for Reversible Guest Binding 0.27
An Engineered Multivalent TMV Nanodisk Platform for Modulating Integrin Clustering and Cell Signaling 0.66
AM-DMF-ddRPA: an All-in-One Digital Microfluidic Platform for Rapid and Automatic Digital Nucleic Acid Analysis 0.39
6 1.47
2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity 0.52
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models 0.45
Fibroblast bioelectric signaling drives hair growth 0.02
A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells 0.13
A mechano-resistance mechanism in skin adapts to terrestrial locomotion 0.01
Senescence-resistant human mesenchymal progenitor cells counter aging in primates 0.34
5 0.88
Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair 0.12
Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection 0.18
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy 0.52
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling 0.05
Human airway submucosal gland organoids to study respiratory inflammation and infection 0.02
2 1.03
Rapid detection of antibiotics using self-developed electrochemical analyzer and sensor chip 0.40
iS/i-Nitrosylated Au@COF nanohybrids for synergistic light-nitric oxide killing of bacteria 0.63
2 0.85
A preliminary profile of RNA bound on the cell surface 0.25
A simple epoxide modification strategy to construct amino-functional poly(2-oxazoline) mRNA delivery vectors 0.60
2 0.83
Usage Analysis and Multicriteria Alternative Assessment of Alternative Plasticizers: Are They Safer Alternatives? 0.40
Continuously Responsive Surface-Enhanced Raman Scattering Sensors for Long-Term On-Site Free Chlorine Monitoring in Aquatic Environments 0.43
1 0.05
Metal–Organic Framework-Based Self-Powered Chemodynamic Therapy Nanosystem: CaO2@PCN-222(Fe) and Its Mixed Matrix Membranes for Promoting Infected Wound Healing 0.05
1 0.12
Topologically associating domains define the 3D genome architecture of mouse totipotent-like stem cells 0.12
16 4.49
Diffusion-Mediated Synthesis of Durable High-Entropy Sulfide Nanocrystals: Le Chatelier-Driven and Electron Configuration Effects 0.01
Site-Specifically Modified Circular Ribonucleic Acid Serves as Multitarget miRNA Sponge with Low Immunogenicity 0.02
Bioinspired Diffusion-Limited Silicification in Coacervate Assemblies Enables Smart Nanotoroids for Deep and Sensitive Tumor Penetration 0.03
Unraveling the Role of Ionizable Lipid Isomerism in Modulating Lipid Nanoparticles for mRNA Delivery 0.17
Engineering Polymer–Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery 0.42
Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing 0.08
FAP-Synergistic Organ-Targeted mRNA-LNP for Overcoming Delivery Barriers in Hepatic and Pulmonary Fibrosis 0.06
Structure–Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia 0.10
Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity 0.68
Hydrogen Bond-Assisted Two-Component Lipid Nanoparticles for Spleen-Specific mRNA Delivery 0.43
A General Synthesis Strategy for Alkali Metal Halide Nanosalts 0.62
Personalized Cancer-Specific Protein-Aptamer Corona for Orthogonal Multiplex Cancer Diagnosis 0.42
mRNA-Based FRET-FLIM Imaging Platform for Quantifying Lipid Nanoparticle Endosomal Escape and Membrane Damage 0.18
Ultrasound-Activatable Lipid Nanoplatform for Region-Confined Innate Immune Stimulation and mRNA Vaccination Therapy of Cancer 0.41
High-Throughput Multiplexed Quantification of Molecules by Aptamer Sequencing (Apt-seq) in Single Cells 0.36
Ultrasound-Triggered Activation of p-Azidobenzyloxycarbonyl-Based Prodrugs via Radical-Mediated Cascade Elimination 0.50
7 2.46
Mass Spectrometry-Assisted High-Throughput Discovery of Lung-Specific Lipid Nanoparticles for In Vivo Protein Delivery 0.25
Interfacial Electric Locking of the Aptamer Conformation for Accurate Liquid Biopsy Detection 0.04
Single-Atom-Engineered Implant Materials with Lactate Dehydrogenase-Like Activity for Sustainable Bone Repair and Regeneration 0.13
Nanopore Fingerprinting of Structurally Diverse Amino Acid-Conjugated Bile Acids 0.50
Fluorinated Covalent Organic Framework Films Modified Graphene Field-Effect Transistor Biosensors with Size-Dependent Sieving and Antibiofouling Effect 0.40
Nebulized Lipid Nanoparticles Deliver mRNA to the Liver for Treatment of Metabolic Diseases 0.50
Nanopore-Based Electroporation Enables High-Efficiency, Rapid RNA-Mediated Reprogramming of Primary Fibroblasts into Human iPSCs 0.65
1 0.53
Modelling late gastrulation in stem cell-derived monkey embryo models 0.53
2 0.20
Transcription-independent induction of rapid-onset senescence is integral to healing 0.01
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures 0.19
29 6.15
Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds 0.08
Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury 0.05
Endogenous VEGF signaling acts as a guardian of human primed pluripotency 0.33
Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia in mice 0.09
Cryo-ET comparison of the hierarchical ultrastructure of silkworm, spider, and artificial silk fibers 0.65
Bio-orthogonal functionalization of bacterial cellulose combining metabolic glycoengineering and click chemistry 0.46
Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release 0.43
Lymphatic–stem cell crosstalk promotes tendon regeneration via Notch1–Srebp2–mediated cholesterol metabolism 0.02
Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice 0.39
Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis 0.08
Breaking the durability barrier with d band optimized Cu Fe twin crystal nanozymes for long term suppression of Botrytis cinerea 0.10
Controlled microphase separation and strain programming in hydrogel fibers toward biomimetic architectures and properties 0.11
Autocrine ECM molecules establish MSC quiescence during incisor development by disrupting WNT ligand trafficking process 0.06
Thermally programmed one-pot CRISPR assay for on-site pandemic surveillance 0.06
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitment 0.64
Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex 0.02
Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth 0.19
Common genetic variation influencing the human lung imaging phenotypes 0.07
Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke 0.04
Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery 0.64
Nuclear entry of AS160 as a transcriptional regulator of satellite cells for muscle regeneration 0.13
Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacy 0.52
Metal-organic polyhedra maintain the self-renewal of embryonic stem cells 0.08
Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice 0.29
Space-confined synthesis of sinter-resistant high-entropy nanoparticle library 0.08
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation 0.01
In vitro generation of a ureteral organoid from pluripotent stem cells 0.17
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS 0.36
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke 0.02
3 0.98
Monolithic cell-on-memristor architecture enables wafer-scale integration of oscillatory chemoreceptors for bio-realistic gustatory chips 0.50
Tissue-specific mRNA delivery and prime editing with peptide–ionizable lipid nanoparticles 0.42
Peptide codes for organ-selective mRNA delivery 0.05
9 3.17
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo 0.03
Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation 0.19
m6A epigenetic modification of viral RNA is critical for the transmission cycle of mosquito-borne flaviviruses 0.88
Charge-reversal proteolysis polymers enable tissue-specific STING degradation in rheumatoid arthritis 0.06
Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification 0.03
Adult neural stem cells mediate hippocampal synapse elimination for circuit homeostasis through MERTK 0.64
Fluorinated lipid nanoparticles enable real-time tracking of mRNA delivery and uncover spatiotemporal mechanisms of immune activation 0.51
Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis 0.23
Structural basis and affinity improvement for an ATP-binding DNA aptamer 0.58
1 0.02
CRISPR/Cas9-Engineered Triple-Fusion Reporter Gene Imaging System for Monitoring Transplanted Neural Progenitor Cells in Ischemic Stroke. 0.02
2 0.53
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors 0.25
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling 0.28
3 0.51
Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair 0.42
Xenopus IgX informs engineering strategies of IgM and IgG hexamers 0.07
Widespread presence of bone marrow–like hematopoietic stem cell niche in invertebrate skeletons 0.02
1 0.50
Receptor Targeting Amplifies Curvature-Driven Cooperative Nanoparticle Internalization under Redox Control 0.50

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