Medicinal and Biomolecular Chemistry articles for Germany

Time frame: 1 May 2025 - 30 April 2026

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Count: 113

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count Share
1 0.10
Mapping the Functional Architecture of Influenza A Virus-Induced Phase Separation through m6A Proximity Labeling 0.10
3 1.56
The human osteocyte lacunocanalicular network structure in osteons of the iliac crest of elderly women depends on mineral content but not individual age 0.43
Spatio-temporal characterization of compositional and cellular properties in the murine fracture callus 1.00
Bioactive glass-induced B cell depletion remodels the osteoimmunological microenvironment to enhance osteogenesis 0.14
3 0.61
Stabilizing Proteins by Chemical Cross-Linking: Insights into Conformation, Unfolding, and Aggregation Using Native Ion Mobility Mass Spectrometry 0.07
Lasso Peptide Syanodin I: Loop-Pulling Two-Step Thermal Unthreading Mechanism 0.13
Sulfoxide-diazirine (SODA) as a Cleavable Photoaffinity Group To Enable the Identification of Photolabeled Modification Sites via LC–MSsup3/sup 0.42
7 5.80
Ansamer‐Controlled Bicyclic Peptides as Integrin αvβ6 Targeting Agents 0.15
Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases 1.00
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation 1.00
Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities 0.71
Studies of α′,β′-Epoxyketone Synthesis by Small-Molecule Flavins and Flavoenzymes 1.00
High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly 0.94
Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases 1.00
3 1.57
Nuclear speckles enable processing of RNA from GC-rich isochores 0.47
Metabolically regulated proteasome supramolecular organization in situ 0.75
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates 0.35
1 0.40
Forces behind N- and C-capping of peptidic helices 0.40
6 4.21
Mass spectrometry detects folding intermediates populated during urea-induced protein denaturation 1.00
Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils 0.17
Yeast [FeFe]-hydrogenase-like protein Nar1 binds a [2Fe–2S] cluster 0.78
Impact of vibrational strong coupling on liquid–liquid phase separation in supramolecular polymers 0.26
Phylogeny-guided discovery of a promiscuous P450 macrocyclase for the production of diverse atropopeptides 1.00
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives 1.00
2 0.35
PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS 0.06
The trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA 0.29
1 0.22
Pex30-dependent membrane contact sites maintain ER lipid homeostasis 0.22
1 0.67
Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release 0.67
13 6.55
Beyond a Passive Tether: Structural Insights into the Disordered Tail of Hsp90 0.18
Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation 0.64
Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry 1.00
Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting 1.00
DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions 0.78
Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA 0.17
Chemically Fueled, Active Droplets Prevent the Aging of Peptides into Amyloid-Like Fibers 0.80
De Novo Discovery of α,α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors 0.29
Pushing Sensitivity and Specificity Limits in Native Structural Biology: sup19/supF Multinuclear Dynamic Nuclear Polarization with Magic Angle Spinning 0.17
Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase 0.02
Controlling Multiphase Coacervate Wetting and Self-Organization by Interfacial Proteins 0.25
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET 0.25
Molecular Tweezers Block the Functional Pore of a Protein Machine 1.00
7 1.74
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes 0.03
NAC promotes co-translational protein folding at the ribosomal tunnel exit 0.38
Engineering intrinsically disordered regions for guiding genome navigation 0.10
The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis 0.40
Membrane-protein-mediated phase separation orchestrates organelle contact sites 0.42
Mechanical forces regulate the composition and fate of stalled nascent chains 0.25
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery 0.18
3 2.22
Single-molecule dynamics of the TRiC chaperonin system in vivo 1.00
NAC controls nascent chain fate through tunnel sensing and chaperone action 0.62
Probing condensate microenvironments with a micropeptide killswitch 0.61
4 0.98
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection 0.04
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions 0.86
Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein 0.06
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy 0.03
1 0.15
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning 0.15
1 0.57
Profiling the proteome-wide selectivity of diverse electrophiles 0.57
19 12.33
Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization 0.62
Covalent modification of a glutamic acid inspired by HaloTag technology 1.00
Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly 1.00
Structural basis of co-translational N-myristoylation in humans 0.63
The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb 0.75
Lucerastat, an oral therapy for Fabry disease: results from a pivotal randomized phase 3 study and its open-label extension 0.09
Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress 1.00
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo 0.87
Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy 0.30
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling 0.06
Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities 1.00
The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses 1.00
4D structural biology–quantitative dynamics in the eukaryotic RNA exosome complex 1.00
Quantifying collective interactions in biomolecular phase separation 0.25
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits 0.70
Coupling chromosome organization to genome segregation in Archaea 0.22
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma 0.28
Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates 1.00
Proteome-wide determinants of co-translational chaperone binding in bacteria 0.58
1 0.93
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation 0.93
1 0.29
Phosphorylation-dependent tuning of mRNA deadenylation rates 0.29
1 0.14
AuCl3–tBuCN Catalysis in 1,2-trans 2-Deoxy-2-fluoro Glycosidic Bond Formation 0.14
1 0.18
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation 0.18
2 0.25
Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains 0.07
Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis 0.18
1 0.92
Nonequilibrium Structure and Relaxation in Active Microemulsions 0.92
1 0.95
Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco 0.95
11 5.84
Non-Fickian diffusion within assemblies of the intrinsically disordered protein β-casein 0.33
The assembly rules guiding hetero-oligomeric bacterioferritin organization and their evolutionary signature 0.22
Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis 0.09
Probing direct interactions between nuclear proteins in cells with nxReLo 0.80
The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster 1.00
The RANK/RANKL axis controls vascular dynamics in the bone marrow 0.01
The functional dynamics of FicD’s TPR domain are modulated by the interaction with ATP and BiP 0.57
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions 1.00
Trigger factor accelerates nascent chain compaction and folding 0.39
The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins 0.58
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro 0.83
1 0.23
Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning. 0.23
1 0.85
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes 0.85
8 4.89
Bacteria use P-body condensates to attenuate host translation during infection 0.82
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling 0.64
Functional characterization of dynamic nascent RNA folding ensembles in real time 1.00
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress 0.38
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule 0.21
Cotranslational protein folding through non-native structural intermediates 0.60
The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat 0.67
UFMylation orchestrates spatiotemporal coordination of RQC at the ER 0.57
1 0.02
Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome 0.02
3 1.95
Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation. 0.59
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides 0.36
Dysfunctional mitochondria trap proteins in the intermembrane space. 1.00
3 1.51
Spectral Fingerprints of Hydrogen-Bonding in Water Solvation of Amino Acids 0.43
Probing the Triplet State by Cryogenic Ion Trap IR Spectroscopy─Application to Protonated Lumiflavin 0.08
UV Resonance Raman Spectroscopic Marker Bands of Base Pair Formation During Nucleic Acids Assembly 1.00
1 1.00
Molecular determinants underlying NPH3 condensation and function in phototropism: an integrative approach 1.00

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