Medicinal and Biomolecular Chemistry articles for Japan

Time frame: 1 June 2025 - 30 May 2026

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Count: 80

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count Share
3 2.09
Emergence of Anisotropic Subcompartments via Coassembly of Hierarchically Ordered G-Quadruplexes and Fluid Polylysine in Droplet-Based Compartments 1.00
Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain 1.00
Hierarchical Structural Organization in Bioinspired Peptide Coacervate Microdroplets 0.09
2 1.11
Elucidation of the Effects of Electrostatic Interactions on Protein Structures at Buried Solid/Liquid Interfaces: A Combined Study with Experiment, Simulation, Isotope Labeling, and Spectra Calculation 0.11
Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR 1.00
5 2.91
A Non-Covalent [4Fe–4S]/[2Fe] Interface in HydF Guides [FeFe]-Hydrogenase Maturation 0.05
DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1 1.00
Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides 0.75
Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding 0.94
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain 0.17
1 0.33
Nuclear speckles enable processing of RNA from GC-rich isochores 0.33
2 2.00
Strategic alkene incorporation into peptide backbones to prevent enzymatic hydrolysis by evading molecular recognition 1.00
Backbone cleavage of peptides and proteins ivia/i cysteine iS/i-fluoroacetylation 1.00
4 3.40
Engineering β-sheet morphologies via metal cross-linking and side chain modifications 1.00
Light responsive hydrogen selenide (H2Se)/hydrogen diselenide (H2Se2) donors: applied for protein S-selenylation on PRDX6 0.40
Intracellular evaluation of protein droplet-forming capability using self-assembling peptide tags 1.00
Bottom-up design of peptide shapes in water using oligomers of N-methyl-l/d-alanine 1.00
1 0.75
Deceleration of Proton Exchange between Monosaccharides and Water by Metallocryptand and Related Compounds 0.75
2 2.00
The iron-sulfur cluster assembly factor FDX2 is required for tumor initiation but not for growth of established tumors in transplantation models. 1.00
Hyaluronic acid regulates cellular UDP-GlcNAc levels through CD44 to affect glycosylation and cell biological functions 1.00
1 1.00
Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins 1.00
1 0.15
Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release 0.15
23 16.47
Phase Separation Driven by Dynamic Interactions in the N‑Terminal Intrinsically Disordered Region of the DEAD-Box RNA Helicase DDX3X 1.00
Proximity of the Histone-Acetylation Site to the Termini Shapes Phase Behavior with DNA 1.00
OptoChaperoneA Biohybrid Tool for Regulating Protein Condensates in Cells and In Vitro 0.96
RaPID Selection of α-Hydrazino Acid-Containing Macrocyclic Peptides 1.00
Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation 0.36
Discovery of Ultrapotent Heterodimeric Peptide Ligands Using Library-vs-Library RaPID Selections 0.83
Directional Engineering of Cyclic β-Hairpin Peptides for PET/CT Imaging of PD-L1 0.07
Single-Cell Native Mass Spectrometry for In Situ Detection of Protein–Drug Complexes in Live Cells 1.00
Mesostructured Water Enhances Stability of ProteinMPNN-Designed Ubiquitin-Fold Proteins 0.09
Chemical Protein Synthesis via Direction-Switching One-Pot Peptide Ligation Enabled by Orthogonal Cysteinyl Protection 1.00
Linkage-Editing of β-Glucosylceramide and β-Glucosylcholesterol: Development of β-Selective C-Glucosylation and Potent Mincle Ligands 1.00
Monomer Isolation from Oligomeric Proteins within Coordination Cages to Study Interface Ligand Binding 1.00
De Novo Discovery of α,α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors 0.71
Ribosomal Elongation of Trans-4-Aminocrotonic Acids into Nascent Peptide Chain 1.00
Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design 0.03
β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins 1.00
Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates 0.86
Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase 0.95
Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ2 0.13
Pushing Sensitivity and Specificity Limits in Native Structural Biology: sup19/supF Multinuclear Dynamic Nuclear Polarization with Magic Angle Spinning 0.33
Direct Cellular Screening of Pd-Mediated Arylation of Cyclic Peptide Binders Targeting Ubiquitin Chains: Toward Modulating NEMO Liquid–Liquid Phase Separation 0.14
iDe Novo/i Peptides That Induce the Liquid–Liquid Phase Separation of α-Synuclein 1.00
An α-Helically Folded α-Aminoisobutyric Acid (Aib) Oligomer That Assembles into a Metal–Peptide Superhelical Nanotube 1.00
3 1.49
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes 0.08
Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility 1.00
Membrane-protein-mediated phase separation orchestrates organelle contact sites 0.42
1 1.00
Structural Dynamics of the Afamin/Wnt3a Complex Mediated by the Afamin Hydrophobic Pocket 1.00
1 0.85
Ca-driven PDIA6 biomolecular condensation ensures proinsulin folding 0.85
1 0.03
Photosensitizer proximity labeling captures the lipid and protein interactomes 0.03
1 0.02
Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics 0.02
8 4.74
Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape 0.03
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain 0.88
Zinc finger domains bind low-complexity domain polymers 1.00
Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein 0.12
KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpB 1.00
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging 0.64
Phase separated condensates of ATRX regulate neural progenitor identity 1.00
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking 0.07
1 0.05
Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial 0.05
7 6.07
Chemical Synthesis of Difucosylated Glycopeptide by the Combination of Substituted Benzyl and Levulinoyl Protecting Groups 1.00
Total Chemical Synthesis of the Human Milk Oligosaccharide Disialyllacto-N-tetraose and Its Degradation by Bifidobacterium bifidum Sialidases 1.00
An o-Nitroveratryloxycarbonyl-Based Photolabile Solubilizing Tag for the Chemical Synthesis of Poorly Soluble Peptides and Proteins 1.00
A Sequential Iodination–Fluorodeiodination of the Cubane Scaffold 0.25
Liquid-Phase Peptide Synthesis of Tropolone–Peptide Hybrid Antimalarials 1.00
Toward N-Linked Glycoproteins: Three-Step Synthesis of Glycan-Asparagine Conjugates from Unprotected Sugars 1.00
Investigation of the Reactivities of Halogen-Substituted Bicyclic Sialic Acid Donors and Their Application 0.82
1 0.73
HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice 0.73
1 1.00
Symmetry analysis of cross-circular and parallel-circular Raman optical activity 1.00
4 1.23
Accurate conformational ensembles of intrinsically disordered proteins using reweighting based on NMR chemical shifts 0.03
Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization 0.13
The RANK/RANKL axis controls vascular dynamics in the bone marrow 0.83
The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins 0.25
3 0.18
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis 0.03
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling 0.04
The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat 0.11
1 0.04
Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome 0.04
2 1.83
Probing the Triplet State by Cryogenic Ion Trap IR Spectroscopy─Application to Protonated Lumiflavin 0.83
Investigation of Chemical Properties within Chaperonins in Stabilizing Substrate Protein Conformations Using Biomolecular Environment-Mimicking Model 1.00

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