Medicinal and Biomolecular Chemistry articles for Chinese Academy of Sciences (CAS), China

Time frame: 1 June 2025 - 30 May 2026

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Count: 78

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count Share
1 0.66
RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction 0.66
2 0.95
Modulation of Ice Formation and Removal Dynamics by Antifreeze Protein-Inspired Large-Area Films 0.36
Deep Learning-Driven Co-Assembly of Naturally Sourced Compound Nanoparticles for Potentiated Cancer Immunotherapy 0.59
7 3.44
MOSCAT: Aldehyde-Selective Chemical Proteomics for Site-Specific Profiling of Cinnamaldehyde Targets in Living Cells 0.50
Nonmodified Strategy Enabled Proteome-Wide Mapping of Catechol Derivatives Interactome 0.80
TIPP: A Novel Iodoacetamide Reaction-Induced Protein Precipitation Approach for Proteome-Wide Ligand-Target Identification 0.50
Mapping Protein-ssDNA Interactions at Single Nucleotide Resolution by Dual Nucleases-Assisted Next-Generation Sequencing 0.52
Acrolein as an Alternative Broadly Reactive Activity-Based Probe for Activity-Based Protein Profiling of Cysteinome 0.78
FRAP4ICBS: FRAP Analysis Method to Evaluate Dominant Effects for Biomolecular Condensate Formation 0.17
Spatially Resolved Multibait Mapping of Stress Granule and Processing Body Transcriptome 0.18
9 2.73
Total Chemical Synthesis of Interleukin-15 and Interleukin-2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy 0.02
Modular Synthesis of Neisseria meningitidis Lipooligosaccharide Inner Core Oligosaccharide Library to Identify Broadly Reactive Antigenic Epitopes 0.78
Expeditious Synthesis of 2‐Deoxy‐2‐perfluoroalkyl Glycosides 0.10
Side-Chain Engineering Guides the Design of β-Sheet Inhibitor to Anchor Protein-Protein Interaction Interfaces 0.15
Coexistence of G‐Quadruplex and i‐Motif Within a DNA Duplex is Tolerated by a PCBP2‐Assisted Replisome 0.10
A Picolyl-Based Cys Caging/Uncaging Strategy Facilitates Protein Synthesis 0.33
Electrochemical Late-Stage Stitching of Tryptophan Peptides via N─S Bond Formation 0.36
Visible‐Light‐Controlled Lysine‐Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells 0.49
Proteome‐Wide Data Guides the Discovery of Lysine‐Targeting Covalent Inhibitors Using DNA‐Encoded Chemical Libraries 0.41
1 0.01
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2 0.01
3 0.81
Chiral biphenanthrene-diol-based lanthanide cubanes 0.33
Chemoenzymatic synthesis of sulfated O-glycopeptides from human CD34 0.39
Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy 0.08
3 0.89
Design of permeability-optimized target-binding macrocycles via direct preference optimization 0.08
Guanine nucleotide directed co-assembly with Pt-complexes for tailoring chiroptical properties and multimodal molecular recognition 0.52
Unprecedented allosteric inhibition of E. coli malate dehydrogenase by silver(i) from atomic resolution analysis 0.29
1 0.64
Negatively charged α-synuclein condensate modulates partitioning of molecules 0.64
14 4.34
Distinct RNA Physical Microenvironments Shape Unique Properties and Functions within Biomolecular Condensates 0.10
Molecular Dynamics-Guided Design and Chemoproteomic Profiling of Covalent Kinase Activity Probes 0.01
Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity 0.78
Partially Protected N-Acetylglycosamine Donors Enable Direct β-O-Glycosylation: Applications and Mechanistic Insights 0.53
Group Competition Strategy for Covalent Ligand Discovery 0.20
Total Synthesis of the TIM-1 IgV Domain via N-to-C Serine/Threonine Ligation Enabled by Knorr Pyrazole Synthesis-Mediated Regeneration of Salicylaldehyde Esters 0.01
Decoding Arginine Dimethylation Isomers via pH-Tuned Reactivity with Methylglyoxal: A Chemical Approach for Functional Proteomics 0.57
Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation 0.63
Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy 0.45
Site-Specific Profiling of RNA-Binding Proteins Enabled by Isotopic Signature-Enhanced Mass Spectrometry 0.40
Beyond the Amyloid Core: Modulation of Aggregate Conformational Diversity by Mutations in the Noncore Regions 0.22
Ribosomal Incorporation of Fluorosulfonyloxy-l-Phenylalanine into Macrocyclic Peptides for De Novo Target-Specific Covalent Binders 0.06
Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the SARS-CoV-2 Proofreading Enzyme 0.04
β-Thioglycosylation from Unactivated Carbohydrates 0.36
1 0.13
Mesangial Cell–Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture 0.13
1 0.12
The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis 0.12
1 0.19
Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer’s disease 0.19
2 0.44
Conformational Adaptability and Thermostability in α/β-Peptide Fibrils Induced by β-Amino Acid Substitution 0.24
Submolecular Resolution Imaging of Amyloid Aggregation: An STM Approach to Decipher Missense Mutation Effects in α-Synuclein 0.20
2 0.73
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome 0.69
Diffusing protein binders to intrinsically disordered proteins 0.03
1 0.01
Proximal proteomics reveals a landscape of human nuclear condensates 0.01
1 0.26
HO-free proximity proteomics for exploring dynamic protein complexes in living systems 0.26
12 3.93
Electrostatic bimodality of human cytosolic DNA sensor cGAS-dsDNA condensates revealed by millisecond flashing electrophoretic separation 0.52
Novel CuCLIP-seq for in situ covalently captured protein-binding RNAs 0.75
A framework for the exploration of subcellular compartmentalization of RNA-binding proteins 0.21
Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation 0.53
Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates 0.17
Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase 0.03
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells 0.81
Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates 0.09
In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy 0.08
Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models 0.50
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking 0.14
Emergent mechanics of a networked multivalent protein condensate 0.08
1 0.47
Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffolds 0.47
6 2.28
Rapid Access to Human Milk Oligosaccharide Analogues through a Partially Protected N‑Acetylglucosamine Donor 0.45
Highly Stereoselective 1,2-cis-Glycosylation with 2-Azidofucosyl Donors: Access to the Pentasaccharide Motif from Escherichia coli O4:K6 0.50
Stereoselective Assembly of 2-Deoxy-2-fluoroglycosides Enabled by Pyridinium Catalysis 0.01
Phage Display of Graspeptides via SrtA-Mediated Peptide Ligation and Cyclization 0.11
Palladium-Catalyzed Glycosylation for the Highly Stereoselective ide Novo/i Construction of Trideoxy Glycan Motifs from Pyridapeptides B-E 0.50
Stereoselective Glycosylation of Amino Sugars Enabled by Thiourea/Phosphoric Acid Dual Catalysis 0.70
3 0.56
Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519 0.04
CDKL5 modulates the plasticity of excitatory synapses via liquid–liquid phase separation 0.33
De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation 0.19
2 0.48
Highly efficient α-sialylation with ortho-(1-phenylvinyl)benzoates as leaving groups: One-pot assembly of α-sialoglycans 0.30
Translation landscape of stress granules 0.18
1 0.55
Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells 0.55
3 0.82
Nanoscale Mechanical Force Primes NOD1-LRR for Efficient Pathogen Recognition 0.09
Single-Molecule Fluorescence Spectroscopy of 4-Cyanotryptophan and Its Application in Photoinduced Electron Transfer Fluorescence Correlation Spectroscop 0.50
AlkD’s Conformational Dynamics Regulated by Protein–DNA Interactions for Effective Target Recognition 0.23

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