Pharmacology and Pharmaceutical Sciences articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 608

Article ‘Count’ for Pharmacology and Pharmaceutical Sciences.

Journal Count Share
19 13.79
Zwitterionic Lipid Nanotherapeutics from Mulberry for Oral Treatment of Diabetic Colitis 0.05
Insights into the Structure of Ultrasmall Fluorescent Core–Shell Silica Nanoparticles 1.00
Immune Modulatory Oxysterols Produced from Cholesterol-Containing Lipid Nanoparticles Regulate Tumor Growth 1.00
A Redox-Responsive Selenium-Containing Nanomedicine Enables Dual Antioxidant System Inhibition to Overcome Platinum Resistance and Enhance Immunotherapy in Bladder Cancer 0.06
Utilizing Constrained Bicyclic Peptides for In Vitro Diagnostics 0.50
Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries 1.00
Anti-Aggregation System for the Enhanced Transdermal Delivery of Cell Membrane-Coated Nanoparticles 0.05
Controlling Polymerization-Induced Phase Separation in the Synthesis of Porous Gels 0.20
Precise Ratiometric Drug Delivery for the Treatment of Triple-Negative Breast Cancer 0.92
Dual-Action Cellular Nanoparticles for Effective Lead (Pb2+) Detoxification 1.00
Injectable Microparticle-Nanoliposome Hydrogel for Extended Release of Small Hydrophilic Molecules 1.00
Role of Serum Stability and Lipoprotein Interactions in Lipid Structure–Tumor Accumulation Relationship 1.00
Meta-Analysis and Machine Learning Prediction of Protein Corona Composition across Nanoparticle Systems in Biological Media 1.00
Endolysosomal Sequestration Effects Controlled Release of BRAF Paradox Breaker Nanoparticles 1.00
Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control 1.00
TuNa-AI: A Hybrid Kernel Machine To Design Tunable Nanoparticles for Drug Delivery 1.00
Mucoadhesive and Self-Assembled Chitosan Oligosaccharide-Glycyrrhizin Nanoparticle for Oral Nanotherapeutic in Inflammatory Bowel Disease 0.06
Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines 1.00
Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel Platform Enables Immunophenotyping at the Single-Cell Scale 0.96
4 3.13
Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo 1.00
Gadolinium nanoparticle-enhanced, radiopaque, and resorbable inferior vena cava filters for improved in vivo applications 0.97
Gastrointestinal distribution of engineered biodegradable urease-powered nanomotors 0.17
Enhanced delivery of camptothecin to colorectal carcinoma using a tumor-penetrating peptide targeting p32 1.00
9 5.39
Engineering Pendant Group Chemistry to Control Hydrophilicity and Oxidative Degradation of Thioketal-Based Biomaterials 1.00
A Bioresorbable Neural Interface for On-Demand Thermal Pain Block 0.71
Spleen-Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle-Fused Lipid Nanoparticles 0.27
Nonclassical Modes to Inhibit β‐Hematin Crystallization 1.00
Free-Form Microfluidic Microneedle Array Patches 1.00
Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection 1.00
Unleashing the Power of Machine Learning in Nanomedicine Formulation Development 0.06
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function 0.25
Four‐Pronged Nanomotor Strategy Achieves Efficient TNBC Treatment via Synergistic Chemo‐Photothermal‐Immune Therapy 0.10
9 6.19
Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens 0.10
High Concentration Antibody Formulations Enabled via Thermostable Ionic Liquids 1.00
Dismantling the Necroptotic Engine: An Oral Theranostic Nanosponge for Ulcerative Colitis 0.13
Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract 0.05
High‐Concentration Antibody Formulation via Solvent‐Based Dehydration 1.00
Colloidal Heterostructures Enable Interfacial Transport of Immiscible Molecules in Printable Organohydrogels 1.00
Signal Transducer Nanoparticles Enable Siglec‐10/G Blockade Immunotherapy for Breast Cancer Treatment 1.00
Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers 0.92
Enhanced Control of Liposomal Drug Release by Drug–Aptamer Complexes 1.00
1 0.88
Blood micronutrients modified associations between blood heavy metals and cognitive decline in a nationally representative cross-sectional study 0.88
1 1.00
Leukotriene modifying agent chemoprophylaxis for severe influenza illness: A multi-approach study 1.00
2 1.14
Venous thromboembolism with combined oral contraceptives based on estrogen and progestin content: a disproportionality analysis of the United States Food and Drug Administration Adverse Event Reporting System database 0.14
Azithromycin in preterm premature rupture of membranes: population pharmacokinetics and dose optimization 1.00
20 18.60
Evaluating Antibody Quality via Simultaneous Size and Charge Measurement with Single Protein Oscillators 0.69
Molecular Behavior of Antibodies IgG‑1 and IgG‑4 at Buried Polymer/Solution Interfaces Probed by Sum Frequency Generation Vibrational Spectroscopy 1.00
Multiplex Detection and Quantification of miRNAs in Drug Delivery Systems Using a Signal-Off Electrochemical Platform 0.03
Characterizing Noncovalent Therapeutics in Biomatrices by Native Affinity Capture Mass Spectrometry: Biotransformation of Antibodies Conjugated with Small Molecules and siRNA 1.00
Measuring the Degree of Labeling of Antibody-Dye Conjugates with a Single-Molecule-Sensitive Digital Flow Cytometer 1.00
Polarity- and Sequence-Dependent Ionization of Therapeutic Antibody–siRNA Conjugates: Enabling Intact Multi-attribute Method for Comprehensive Characterization and Identity Release Assay 0.88
A Chemically Inducible Multimerization System for Tunable and Background-Free RTK Activation 1.00
Real-Time Bioconjugation Reaction Monitoring of Antibody–Drug Conjugates with Multiattribute High-Throughput Hydrophobic Interaction Chromatography 1.00
Unveiling Dopamine and Met-Enkephalin Dynamics: Simultaneous Co-Detection in Rat Striatum 1.00
Real-Time Binding Kinetics of Membrane Protein–Protein Interactions in a Membraneless Setting 1.00
Characterization of Hydrogel Drug Delivery System Stability Using Column-Switching Multimodal Liquid Chromatography–Mass Spectrometry 1.00
Increasing the Scale of the Mass Spectrometry Query Language Compendium with Explainable AI 1.00
Theoretical Framework and Experimental Validation of Multiplexed Analyte Quantification Using Cross-Reactive Affinity Reagents 1.00
Early Stage Soft Protein Corona Identification on Nanoparticles via Extended Size Exclusion Chromatography 1.00
End-to-End One-Pot Preclinical Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry Workflow for Simultaneous Quantitation of Total and Conjugated Antibody Levels of Antibody-Drug Conjugates with Protease-Cleavable Linkers 1.00
Two-Cycle Immunoaffinity Enrichment Strategy with Acid Treatment to Enhance Biotherapeutics Assay Sensitivity in Tissues 1.00
Rapid and Wash-Free Anti-Drug Antibody Assay Enabled by a Complementary Nanoluciferase Biosensor 1.00
Iodoacetyl Tandem Mass Tag-Based Site-Specific Free Thiol Analysis (TMT-SiFTA) of Monoclonal Antibodies 1.00
Dissecting Hidden Liraglutide Oligomerization Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics 1.00
Ultrafast Microdroplet Digestion of Antibodies with Fc-Silencing Mutations 1.00
3 2.08
Effect of Paroxetine or Escitalopram Co-administered with Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial. 0.89
Respiratory and antinociceptive effects of NOP-MOP agonist cebranopadol versus full opioid receptor agonist oxycodone: a comparison in healthy volunteers. 0.28
Sensory-selective peripheral and neuraxial nerve blockade with 2',6'-pipecolylxylidine. 0.91
12 6.64
Catalytic ROS‐Amplifying Self‐Immolative Linkers Enable Carrier‐Free Prodrugs for Refractory Tumors 0.14
Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2′,6′-Pipecoloxylidide 0.10
Catalytic & Enantioselective Ring Opening of Azabicyclo[1.1.0]Butyl Carbinols via N-Allylation of Strained Tertiary Amines 0.33
Development of PolyHis‐Targeting PROTAC Degraders 1.00
Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation 0.87
Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters 1.00
Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues 0.35
Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells 0.18
Umpolung Activation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis 0.50
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders 0.83
Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof 1.00
New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain 0.33
2 1.73
Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab’)2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area 1.00
Multicenter Trial of the Emergency Department Trigger Tool 0.73
2 2.00
Impact of Pharmacy Technicians on Clinician and Nurse Work Experience in Primary Care 1.00
Ultrasound Guidance Can Reduce IUD Insertion Time 1.00
4 2.62
Comparative Gastrointestinal Safety of Dulaglutide, Semaglutide, and Tirzepatide in Adults With Type 2 Diabetes. 0.82
Glucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes : A Target Trial Emulation. 0.86
Differences Between Trial Populations and Approved Label Populations of New Drugs in the United States and Europe (2012 to 2023) : A Cross-Sectional Study. 0.39
Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide. 0.56
2 1.07
Does Missing Medication Acutely Change Seizure Risk? A Prospective Study 1.00
Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy 0.07
1 0.71
Super Learner Enhances Postoperative Complication Prediction in Colorectal Surgery. 0.71
2 0.48
Upadacitinib vs adalimumab in patients with rheumatoid arthritis and a prior inadequate response or intolerance to a tumour necrosis factor inhibitor: 12-week results from the randomised, double-blind, SELECT-SWITCH study 0.38
Successful discontinuation of oral glucocorticoids after short-term bridging therapy in patients with newly diagnosed rheumatoid arthritis 0.10
7 4.51
Glucagon‐like peptide‐1 receptor agonist therapy is associated with improvement in psoriatic arthritis‐related and metabolic outcomes: A retrospective analysis of two cohorts 0.71
Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis 0.20
Weighing dose‐related benefits and risks of hydroxychloroquine treatment in systemic lupus erythematosus patients 0.22
Defining Optimally Safe and Effective Blood Levels of Hydroxychloroquine in Lupus: An Important Step toward Precision Drug Monitoring 0.37
Are Glucocorticoids Associated with Worse Survival among Rheumatoid Arthritis Patients with Lung Cancer Treated with Immune Checkpoint Inhibitors? 1.00
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis 1.00
Associations of specific pesticides and incident rheumatoid arthritis among female spouses in the Agricultural Health Study 1.00
1 1.00
Tegmental kappa-opioid receptor neurons modulate opioid withdrawal via the periaqueductal gray 1.00
1 1.00
Clinical Outcomes Associated with Prior GLP-1 Exposure in Burned Patients 1.00
1 1.00
A context-augmented large language model for accurate precision oncology medicine recommendations 1.00
1 0.08
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protein Degradation Approaches 0.08
3 2.13
Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes 1.00
Unified modeling of 3D molecular generation via atomic interactions with PocketXMol 0.22
Nutrient competition predicts gut microbiome restructuring under drug perturbations 0.91
4 1.32
Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling 0.05
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates 0.10
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans 1.00
Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism 0.18
2 0.13
Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis 0.02
Vitamin C conveys geroprotection on primate ovaries 0.11
9 7.08
RCSA-based relative stereochemical analysis of polar molecules in PBLG liquid crystalline medium 1.00
Photocatalytic surface grafting of hydrophobic shells onto hydrogels 0.33
Rotisserie-like motion enables guest transport in a nonporous organic crystal involving a diboron host 0.42
Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils 1.00
Ionic liquid-based transdermal drug delivery systems for biopharmaceuticals 0.33
Solid-phase submonomer synthesis of sequence-defined oligothioetheramides 1.00
Probing polarity structure–function relationships in amine–water mixtures 1.00
The contrasting impacts of polyethylene glycol on electrochemical behaviors of Fe and Zn metal anodes in aqueous batteries 1.00
1,2-Dihydropyrimidine synthesis ivia/i titanium-mediated multicomponent coupling of alkynes, nitriles, and aldehydes 1.00
11 8.90
A machine learning-based workflow for transaminase selection 1.00
Zr6O4(OH)4(O2C-t-Bu)12 precursor uncovers how modulators govern supersaturation, nucleation, and growth of UiO-66 nanocrystals 1.00
Screening pertactin-specific antibodies and evaluating competitive epitope recognition by native mass spectrometry 0.93
Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry 0.94
From polymorphs to cocrystals and salts: successfully predicting axitinib's challenging crystal forms 1.00
Protein chirality as a determinant of ligand affinity: insights from l- and d-streptavidin 1.00
Data-driven recommendation of agents, temperature, and equivalence ratios for organic synthesis 1.00
Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly 0.11
Design, modular synthesis and screening of 58 shape-diverse 3-D fragments 0.06
Guided multi-objective generative AI to enhance structure-based drug design 1.00
Widespread false negatives in DNA-encoded library data: how linker effects impair machine learning-based lead prediction 0.86
2 2.00
Use of and outcomes related to intrapleural enzyme therapy for complicated parapneumonic effusion and empyema in an integrated health system 1.00
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) 1.00
1 0.16
A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients with Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial. 0.16
9 4.18
Electronic Clinical Quality Measures of Antibiotic Use in Hospitalized Adults with Uncomplicated Community-acquired Pneumonia 1.00
Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV 0.65
Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study 0.02
Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study 0.02
Omadacycline Monotherapy in Nontuberculous Mycobacterial Pulmonary Disease Caused by Mycobacterium abscessus: Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study 1.00
Macrolide and non-macrolide resistance after 36 months of mass azithromycin distribution in Burkina Faso: A cluster randomized trial 0.65
Pharmacokinetics of Twice-Daily Tenofovir Alafenamide In Adults with HIV-Associated TB on BIC/FTC/TAF and Rifampicin 0.18
Evaluating the Use of Lower Dose Flucytosine for the Treatment of Cryptococcal Meningitis: A Clinical Trial 0.27
A Phase 2a Study of the Early Bactericidal Activity of Rifampicin in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampicin-Resistant Pulmonary Tuberculosis 0.38
5 1.90
Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP). 0.16
Comparison of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Patients With Septic Shock. 0.50
Methylene Blue Administration in Septic Shock: A Retrospective Cohort Study. 0.07
Effect of Comprehensive Medication Management on Mortality in Critically Ill Patients. 1.00
Clinical Presentation, Laboratory Abnormalities, and Predictors of Outcome in 103 Patients With Acute Paraquat Poisoning: A Prospective Observational Study. 0.17
8 7.41
Differential Longitudinal Effects of Glucose-Lowering Medications on Glucagon and C-peptide Responses in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). 1.00
INHALE-1: A Multicenter Randomized Trial of Inhaled Technosphere Insulin in Children With Type 1 Diabetes. 1.00
GLP-1s Versus DPP-4s and Risk of Dementia in Patients Requiring Hemodialysis: A Target Trial Emulation Study. 1.00
Risk of Acute Pancreatitis and Biliary Events After Initiation of Incretin-Based Medications in Patients With Type 2 Diabetes. 1.00
Tirzepatide Treatment and Associated Changes in β-Cell Function and Insulin Sensitivity in People With Obesity or Overweight With Prediabetes or Normoglycemia: A Post Hoc Analysis From the SURMOUNT-1 Trial. 0.70
Changes in β-Cell Function and Insulin Sensitivity During Treatment With Dapagliflozin Alone or in Combination With Exenatide in Type 2 Diabetes. 1.00
Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment. 1.00
Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. 0.71
9 8.76
Exposure to Organophosphate Ester Flame Retardants and Plasticizers during Pregnancy and Autism-Related Outcomes in the ECHO Cohort 1.00
The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort 0.96
Expanded Tox21 Biological Assay Panel for the Prediction of Drug-Induced Liver Injury and Cardiotoxicity 1.00
Time-Varying Exposure to Element Mixtures and Children’s Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study 0.90
Exposure to organophosphate ester flame retardants and plasticizers during pregnancy and autism-related outcomes in the ECHO Cohort. 1.00
The Association of Arsenic Exposure and Metabolism Biomarkers with Subclinical Measures of Liver Disease: a cross-sectional investigation in the Multi-Ethnic Study of Atherosclerosis. 1.00
Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations. 1.00
Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity. 1.00
Time-varying exposure to element mixtures and children's cognition at 5 years of age: findings from the New Hampshire Birth Cohort Study. 0.90
6 3.93
Beyond hotspots: Estimating population lead exposure from battery recycling 1.00
Urinary total arsenic, arsenic species, and arsenic methylation capacity: an integrative profiling analysis of microRNAs in plasma and leukocytes 0.04
Toxicophore-informed machine learning integrating Tox21 assay readouts for organ system–specific carcinogenicity prediction 1.00
Chronic Sublethal Exposure to Methylmercury Lengthens Telomeres in Developing Zebra Finches 1.00
Novel Graph Neural Network Reveals Binding Mechanisms and Environmental Risks of PAHs Interaction with Estrogen Receptor B 0.14
ACR-16/α7-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria 0.75
34 24.52
Low-dose Inorganic Arsenic Exposure Reprograms Macrophages Differentiation and Function Toward Tumor-promoting Phenotypes 1.00
Prevalent Detection of Multiclass Environmental Chemicals in paired CSF and Plasma Samples and their Potential Associations with Postpartum Depressive Symptoms in Pregnant Women. 1.00
Prenatal and early postnatal lead exposure and later adulthood BMI: The Saint Louis Baby Tooth – Later Life Health Study 1.00
Association between gestational and childhood exposures to organophosphate esters and social skill, problem behavior among adolescents 0.92
Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study 0.94
Association between toenail scandium concentrations and incidence of hypertension among American young adults: 28 years of follow-up 0.83
Arsenic exposure at birth, socioeconomic status, and epigenetic aging among adults in northern Chile 0.86
Plasma organophosphate ester exposure-associated microRNA expression profiles and their functional analysis in Chinese healthy adults 0.08
Pre- and postnatal trace element levels in primary teeth of children with and without an autism spectrum diagnosis 0.29
Benzene exposure biomarkers are associated with recently smoking tobacco and pumping gasoline in the U.S. population aged 12 and over: NHANES 2017–March 2020 1.00
Perinatal exposure to metal mixtures disrupts neuronal function and behavior 1.00
Relationship of serum polycyclic aromatic hydrocarbon (PAHs) and lung function in adults: Evidence from a large community-based population in Guangzhou, China 0.11
Drinking water arsenic, urinary arsenic biomarkers, and cognitive impairment in the REGARDS Study 1.00
Prenatal urinary biomarkers of metal and metalloid exposure and child neurodevelopmental outcomes in Puerto Rico 0.92
High pesticide exposure events and subjective cognitive complaints among US farmers 1.00
Extracellular vesicle microRNAs as an epigenetic biosignature of arsenic-associated diabetes in the Strong Heart Study 0.92
Early-life arsenic exposure modulates the developing microbiome in a rural cohort 1.00
Associations of particulate matter size fractions and chemical composition with conjunctivitis and eczema: epidemiological evidence from the Pearl River Delta, China 0.08
Essential and non-essential metals in children’s intellectual functioning: A multi-media biomarker approach from a Mexico City birth cohort 0.52
The influence of ambient air pollution during folliculogenesis, endometrial development, and spermatogenesis on fertility: A study among patients using vitrified donor oocyte in vitro fertilization 1.00
Associations of children’s urinary metals with blood RNA N-methyladenosine and 2′-O-methyladenosine 0.64
Prenatal exposure to environmental metal mixtures and social development in early childhood: Evidence from a birth cohort and mechanistic study 0.17
Prenatal pesticide exposure and neuroblastoma – A statewide case-control study in California 1.00
Association of prenatal and early-life polycyclic aromatic hydrocarbons exposure with dental caries in childhood 0.62
Estrogen-containing contraceptive use and blood lead concentrations in a cohort of premenopausal individuals 1.00
Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis 1.00
Prenatal exposure to metals and metal mixtures influences birth weight in affected populations in the Republic of Suriname, South America 0.73
Unprecedented lead tolerance in an urban lizard 1.00
Associations of sympathetic activation with exposure to volatile organic compounds: A cross-sectional study 1.00
Sources and geographic differences in air releases of benzene in the United States 0.33
Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease 1.00
Metal exposure and internalizing and externalizing psychobehavioral problems in a Chinese early adolescent cohort 0.09
Associations between prenatal exposure to a mixture of lead, mercury and polychlorinated biphenyls and executive function in Inuit adolescents 0.33
Telomere length declines with mean blood lead concentration in an urban passerine 0.13
21 14.53
Benzalkonium Chloride-Induced Nephrotoxicity in 2D Cultures and a Human Kidney-on-a-Chip System 1.00
Hydrolysis Reaction Rate Prediction Using Machine Learning: WaterDRoP 1.00
Molecular Insights into Ocular Exposure Risk of Indoor Smoke Components on the Tear Film 0.13
Leveraging Large Language Models for Contextual Prioritization of Contaminants of Emerging Concern in Chemical Mixtures 0.14
Pesticide Exposure Characterization Among Adult Males in a Chilean Agricultural Community Using Paired Silicone Wristbands and Urine Samples 0.70
Predifferentiation Neurotoxicity of GenX Exposure on hiPSC-Derived Cortical Neurons 1.00
Interplay of Metals and Organics in E-Cigarette Aerosols Enhances the Production of Reactive Oxygen Species within Ultrafine Particles: Implications for Passive Vaping Exposures 1.00
Detection of Metal-Containing Particles in FDA-Authorized and New Disposable Electronic Cigarette Aerosols 1.00
A Protein Interactome-Based Framework Reveals the General Toxicity of Chemicals 0.17
Sex-Specific Associations of Early Life Exposure to the Pesticide Mixture with Cardiometabolic Outcomes in CHAMACOS Young Adults 0.94
Prenatal Insecticide Exposure and Adverse Birth Outcomes: Evidence for Mediation via Disruptions in Amino Acid and Acylcarnitine Metabolism 0.13
Reaction-Guided Metabolomics Accelerates High-Throughput Annotation of Xenobiotic Metabolites for Human Exposome 1.00
Prenatal Organophosphate Pesticide Exposure and Targeted Maternal Pregnancy Metabolomic Profiles in the NYU CHES Cohort 1.00
Systematic Evaluation of iIn Vitro/i Intestinal Permeability Measurements Across Diverse Chemicals: Insights for Advancing New Approach Methods for Chemical Risk Assessment 1.00
Environmental Exposure to Melamine Derivatives and Early Kidney Injury: Role of Ferroptosis and Oxidative Stress 0.08
Oral Exposure of Arsenic-Contaminated Soils Triggers Hepatic Ferroptosis via Iron Dysregulation and Glutathione Metabolism Disruption: From Bioavailability to Mechanisms 0.13
Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial 0.87
Episodic Exposure to Eucalyptus Smoke during Sperm Maturation Impairs Sperm Motility in Long Evans Rats 1.00
Occurrence of Current-Use Pesticides in Paired Indoor Dust, Drinking Water, and Urine Samples from the United States: Risk Prioritization and Health Implications 0.25
A Liposomal Carrier to Reduce Leaching of Ionic Nutrient Loads in Agricultural Soils 1.00
Tunable NPK Release from Surface-Esterified Nanocellulose-Based Prills 1.00
2 1.10
Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity 0.97
Cardiac transthyretin amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis 0.13
1 0.77
Glucagon-like peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: a Systematic Review and Meta-analysis 0.77
1 0.67
GLP-1 receptor agonist-SGLT-2 inhibitor combination and risk of major adverse liver and cardiovascular outcomes in adults with MASLD and type 2 diabetes. 0.67
1 0.85
Fine particulate matter exposure and sperm DNA fragmentation in US men: a spatial cross-sectional study 0.85
3 1.27
Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity 0.13
On the Use of Ce[N(SiMe3)2]3(THF)n in Catalysis 1.00
Zr-MOF-Derived Zirconium Oxide Nanozyme and Its Hydrogel Composite Membrane for Organophosphate Detoxification 0.14
2 2.00
Mortality and cancer incidence in a large cohort of lead-exposed workers 1.00
The impact of arsenic exposure on DNA methylation in humans: building an epigenetic biomarker of exposure across three independent cohorts 1.00
7 7.00
Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy 1.00
Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults 1.00
Postmarket Drug Safety−Related Actions Before and After the US Food and Drug Administration Amendments Act 1.00
Physical Accessibility of Medicines in Countries Hosting Trials for FDA Approvals 1.00
Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults 1.00
FDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program 1.00
Diabetes Deprescribing in Older Adults 1.00
3 1.68
GH001 vs Placebo in Patients With Treatment-Resistant Depression 0.06
ANK3 as a Novel Genetic Biomarker for Liafensine in Treatment-Resistant Depression 0.73
Efficacy and Safety of Seltorexant in Insomnia Disorder 0.89
2 2.00
MySurgeryRisk Model Predictions of Postoperative Complications and Mortality 1.00
Implementing a Patient-Centered Education Bundle to Improve Venous Thromboembolism Prevention 1.00
6 5.64
Lead-Attributable Cardiovascular Disease Burden 1.00
Electronic Health Record Intervention and Deprescribing for Older Adults 0.97
Gestational Weight Gain and Pregnancy Outcomes After GLP-1 Receptor Agonist Discontinuation 1.00
Arsenic Exposure Reduction and Chronic Disease Mortality 0.67
Everolimus and Low-Dose Tacrolimus After Heart Transplant in Children 1.00
Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder 1.00
18 15.72
Prenatal cannabinoid exposure alters excitation-inhibition balance through glutamate and GABA receptor-mediated signaling 0.60
Dynamic Mechanism for Subtype Selectivity of Endocannabinoids 1.00
Improvement in binding and function of a monoclonal antibody against Shigella flexneri 3a O-antigen via phage display and whole-cell in-solution panning 1.00
Activation dynamics of a water-soluble human mu-opioid receptor 1.00
A tandem recruitment site in the pseudokinase scaffold PEAK3 is subject to phosphorylation-dependent regulation and cancer-associated mutations 0.07
A conserved salt bridge network stabilizes the hepatic organic anion transporters OATP1B1 and OATP1B3 1.00
Engineered IgA-Fc fusion protein with bioactive nanobody neutralizes SARS-CoV-2 variants with mucosal delivery potential 1.00
A humanized transferrin receptor 1-transferrin model supports functional iron homeostasis and therapeutic delivery across the blood–brain barrier 1.00
Development of a recombinant membrane protein ELISA for analyzing antibody responses against SARS-CoV-2 envelope proteins 0.90
Characterization of Mast2 Kinase Defines Structural Features, Regulation, and Substrates 1.00
C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases 1.00
Enhancing O-linking oligosaccharyltransferase functionality through directed evolution 0.90
Dihydroxyacetone decreases the dATP pool, inducing replication stress and genomic instability in BEAS-2B cells 1.00
Interaction of cytochrome P450 3A4 with cannabinoids and the drug darifenacin 1.00
Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases 1.00
Receptor activity–modifying protein 3 enhances GLP-1-mediated insulin secretion 0.25
Repurposing clofazimine as an antibiotic to treat cholera: Identification of cellular and structural targets 1.00
Potential blocker of SARS-CoV entry and a narrow functionality of its spike protein motifs on Qubevirus platform 1.00
2 2.00
Enhancing Osteosarcoma Survival Predictions: A Comparative Study of a Multicomponent-Model Machine Learning Approach Integrating SEER and NCDB Data Sets Versus Conventional Single-Data-Set Modeling. 1.00
Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty. 1.00
1 0.98
ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway 0.98
6 5.81
Patterns of TSH test after GLP-1 RAs initiation in patients on levothyroxine: a trial emulation study 1.00
Exposure to GLP-1RA and Risk of Structural Progression in Differentiated Thyroid Cancer 0.95
Skeletal effect of semaglutide and tirzepatide in patients with increased risk of fractures 1.00
Diazoxide Choline Extended-release Tablets in Prader-Willi Syndrome: A Randomized, Double-blind, Withdrawal Period Study 0.85
GLP-1 receptor agonists in patients with cancer are associated with reduced all-cause mortality and hospitalization 1.00
Increased HSD11β1 Expression in Human Leiomyomatous Uteri: Implication for Enhanced Glucocorticoid Signaling 1.00
7 5.48
Human antibody targeting Crimean-Congo hemorrhagic fever virus glycoprotein 38 protects mice against heterologous virus challenge 0.75
Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potential 1.00
Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice 1.00
Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis 0.11
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity 0.83
The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis 1.00
β-cell Gɑs signaling is critical for physiological and pharmacological enhancement of insulin secretion 0.79
1 0.94
Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy (I-PREDICT) N-of-1 Precision Oncology Study: Molecular Profiling to Match Individually Dosed, Personalized Drug Combinations. 0.94
8 5.86
Pharmacokinetics and Safety of Clofazimine in Women With Rifampicin-resistant Tuberculosis During Pregnancy and the Postpartum Period: Results From IMPAACT P1026s 0.67
Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study 1.00
Establishing a Practical Approach to Sewer Monitoring for Antimicrobial Resistance Genes and Organisms at Healthcare Facilities 1.00
Evaluation of Immunization Route in Induction of Vaccine-Mediated Anti-Gonococcal Immune Responses in a Murine Model of Ascending Infection 0.81
Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India 0.65
Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies 1.00
Fetal Defects in Mice Treated with Integrase Strand Transfer Inhibitors: Comparison of Dolutegravir, Raltegravir, Bictegravir and Cabotegravir 0.09
Translational Modeling of BTZ-043 to Predict Phase 2A Efficacy and Evaluate Drug-Drug Interactions With Bedaquiline, Pretomanid, and Linezolid in Murine Models 0.64
8 8.00
Mitochondrially Transcribed DsRNA Mediates Manganese-Induced Neuroinflammation 1.00
Suppression of In Vitro Epileptiform Activity by GABA Transaminase Inhibition Is Dependent on GABAB Receptors and GABA Transporter Type 1 (GAT1) 1.00
The pro-, but not anti-nociceptive effects of Cannabidiol depend on Trpa1b in larval Zebrafish 1.00
A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2R,6R)-Hydroxynorketamine Metabolite 1.00
Presynaptic trafficking of Glutamate Decarboxylase isoforms is dispensable for basal GABAergic neurotransmission 1.00
Phospho-CREB Regulation on NMDA Glutamate Receptor 2B and Mitochondrial Calcium Uniporter in the Ventrolateral Periaqueductal Gray Controls Chronic Morphine Withdrawal in Male Rats 1.00
Presynaptic Mu Opioid Receptors Suppress the Functional Connectivity of Ventral Tegmental Area Dopaminergic Neurons with Aversion-Related Brain Regions 1.00
Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms 1.00
4 3.90
Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet-induced obesity 1.00
Fentanyl blockade of K+ channels contributes to wooden chest syndrome 0.90
Nicotine influence on cerebrovascular and neurocognitive function with iin utero/i electronic cigarette exposure 1.00
Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation 1.00
1 1.00
Decreased Risk of Cardiovascular Disease in Dermatology Patients Taking Niacinamide: A TriNetX Cohort study 1.00
48 35.49
Optimized Biomimetic Syntheses of Discorhabdin B and Aleutianamine Drives a Deeper Exploration of Their Anticancer Potential 1.00
Ladderanes: Stepping Up as Nonclassical ortho-Substituted Benzene Bioisosteres 0.50
Targeted Coacervates Enabled by Polyphenol–Peptide Networks for Therapeutic Delivery 0.08
Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism 1.00
Glucagon-Like Peptide-1 Receptor Agonists Inhibit the Initiation of Toxic Amyloid-β42 Aggregation 0.77
DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface 1.00
Frozen Interphase Domain and Mechanism of the Snakelike Macroscopic Motion in a Dynamic Crystal Solvate 0.20
Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Protein Degradation 1.00
Biocatalytic Applications and Mechanistic Insights of Deoxypodophyllotoxin Synthase 0.57
Discovery of Covalent Ligands with AlphaFold3 0.33
Cancer Cells Degrade the Nanoparticle Protein Corona for Biosynthesis 0.22
Development of Prostate-Specific Lysosome-Targeting Degraders 1.00
Augmenting Large Language Models for Automated Discovery of F-Element Extractants 0.90
Stability and Degradation-based Proteome Profiling Reveals Cannabidiol as a Promising CDC123-eIF2γ Inhibitor for Colorectal Cancer Therapy 0.06
An Alkaloid Biosynthetic Gene Bundle in Animals 1.00
In Situ Transformable Photothermal Targeting Chimeras for Spatiotemporally Controllable Protein Degradation and Combination Immunotherapy for Cancer 0.08
Polymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors 1.00
Identifying Dynamic Metal–Ligand Coordination Modes with Ensemble Learning 1.00
Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy 0.17
Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA) 1.00
Accurately Predicting Solubility Curves via a Thermodynamic Cycle, Machine Learning, and Solvent Ensembles 0.80
Peristaltic Motion in Structurally Adaptive Molecular Crystals Enables Selective Propyne Capture 0.28
Ketoboronate as a Minimal Covalent-Reversible Tag for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins 1.00
A Selenium-for-Oxygen Swapping Reaction Catalyzed by the Radical S-Adenosyl Methionine Enzyme AbmM 1.00
In Vivo mRNA Delivery to the Lung Vascular Endothelium by Dicationic Charge-Altering Releasable Transporters 1.00
In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy 0.10
Discovery and Biosynthetic Interrogation of a Cobalt-Containing Terpene-Polyketide-Nonribosomal Peptide Tribrid with Anticoronavirus Activity 1.00
Enantioselective β-C–H Arylation of α-Fluoroalkyl Cyclopropane and Cyclobutane Carboxylic Acids 1.00
Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells 0.10
Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes 1.00
Salt-Induced Polymorphs Observed in Colloidal Single Crystals 1.00
Synthesis of Bicyclo[2.1.0]pentanes and Vinylcyclopropanes Using Palladium Carbenes: Ligand-Controlled Carbene Reactivity 1.00
Defluorinative Coupling of (NH)-Heteroarenes and Unactivated Vinyl Fluorides Enabled by Metal–Organic Frameworks 1.00
Direct Synthesis of Bicyclo[1.1.1]pentanes by Sequential C═C, C–C Functionalization Reactions 1.00
Computationally Designed Nanobinders as Affinity Ligands in Diagnostic and Therapeutic Applications 1.00
DNA-Templated Spatially Controlled Proteolysis Targeting Chimera for Cyclin D1–CDK4/6 Complex Protein Degradation 1.00
Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites 1.00
Taming Tautomerism in Organic Crystal Structure Prediction 1.00
Concise Synthesis of Fostriecin and Analogs through Late-Stage Chemoenzymatic Installation of Their Key Pharmacophores 0.67
Phosphorylation-Inducing Molecules for Regulating Dynamic Cellular Processes 1.00
Programmable Liposome Organization via DNA Origami Templates 1.00
In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation 1.00
Identification of Actionable Targeted Protein Degradation Effector Sites through Site-Specific Ligand Incorporation-Induced Proximity (SLIP) 0.21
Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition 0.23
Molecular Design of Unimolecular Tetra-Receptor Agonists 1.00
Development of Sclareol- and Sclareolide-Based Chemoenzymatic Approaches to Ring Intact and Seco Limonoids 0.67
The Binding Affinities of Serum Proteins to Nanoparticles 0.56
Developing Pharmaceutically Relevant Pd-Catalyzed C–N Coupling Reactivity Models Leveraging High-Throughput Experimentation 1.00
3 1.19
Extension Reports in Clinical Trials 0.50
Effect of Aficamten vs Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy 0.66
Sacubitril-Valsartan Versus Enalapril in Heart Failure Due to Chagas Disease: Primary Results of ANSWER-HF Randomized Trial 0.03
9 7.31
Antidepressant Use Among US Nursing Home Residents With Dementia 1.00
Discontinuation of Medications With Limited Benefit at End of Life in Community‐Dwelling Older Veterans 1.00
Mail‐Order and Retail Pharmacy Use Among Medicare Beneficiaries With Alzheimer's Disease and Related Dementias 1.00
Prevalence and Duration of Potential Drug–Drug Interactions Among scpUS/scp Nursing Home Residents, 2018–2020 1.00
Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People 0.06
Integration of Potentially Inappropriate Medication Screening Into Community Pharmacies: A Pilot Study of Feasibility and Impact 1.00
Polypharmacy's Association With Mortality: Confounding From Underlying Morbidity 0.25
Increasing Medicare Part D Vaccine Administrations via a Novel Primary Care Clinic‐Pharmacy Collaboration 1.00
Facilitators of and Barriers to Deprescribing Diabetes Medications in Older Adults: A Qualitative Study 1.00
3 2.56
Tobacco-related urinary biomarkers and lung cancer risk in women, a case-cohort analysis 1.00
Changing standard of care during a randomized trial: examples, considerations and guidelines 1.00
Association between glucagon-like peptidase 1 receptor agonist and obesity-related cancer in overweight or obese patients with type 2 diabetes: a nationwide cohort study 0.56
1 0.50
Zigakibart demonstrates clinical safety and efficacy in a Phase 1/2 trial of healthy volunteers and patients with IgA nephropathy 0.50
5 2.90
Effect of Copolymer Chemistry on the Humidity- and Temperature-Dependent Mechanical Properties and Structure of Polyelectrolyte Complexes 0.57
Coupled Thermal–Chemical Stimuli in Hydrogel Swelling: A Multifield Kinetic Model for Dual-Responsive Hydrogel 0.17
A Hybrid Simulation-Machine Learning Framework for Predicting Thermal Degradation in High-Performance Polyimides 1.00
High-Throughput Generation of Block Copolymer Libraries via Click Chemistry and Automated Chromatography 1.00
Dynamic Hydrogels Using Movable Supramolecular Cores to Prepare Multiarm Macromer Analogs 0.17
2 2.00
Spillover Effects of Opioid Abuse on Skilled Human Capital and Innovation Activity 1.00
Reimbursement Policy and Drug Shortages 1.00
1 0.99
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation 0.99
7 5.89
Sterol pathway disruption in pregnancy: a link to autism 1.00
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium 1.00
Pharmacogenomics of antiepileptic drug mood stabilizer treatment response in bipolar disorder: A MoStGen Consortium study 0.23
Brain CB2 receptor: a new target in medication development for treating opioid use disorder in rodents 1.00
Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice 1.00
CB receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice 0.97
DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort 0.69
5 3.00
Machine Learning Prediction of Analyte-Induced Fluorescence Perturbations in DNA-Functionalized Carbon Nanotubes 1.00
Bacterial Membrane Coating Potentiates Lipid Nanoparticles for mRNA Delivery 1.00
Polymer Blend Controls Nanoparticles’ Surface Charge for Improved Mucus Penetration and Epithelial Cell Adhesion 0.86
Intersection-Free Fractal-Like Structuring of Recombinant Adhesive Proteins for Surface Functionalization 0.03
Targeted Europium Chelation: A Strategy for Intervening Tumor Extracellular Matrix 0.11
12 8.90
A brain reward circuit inhibited by next-generation weight-loss drugs in mice 0.98
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice 0.26
Genetic predictors of GLP1 receptor agonist weight loss and side effects 1.00
A µ-opioid receptor superagonist analgesic with minimal adverse effects 0.93
Collective intelligence for AI-assisted chemical synthesis 1.00
Language model-guided anticipation and discovery of mammalian metabolites 0.52
Inhibitors supercharge kinase turnover through native proteolytic circuits 0.07
Atomically accurate de novo design of antibodies with RFdiffusion 0.91
Crystal structures of agonist-bound human cannabinoid receptor CB1 0.50
Scalable total synthesis of saxitoxin and related natural products 1.00
Identification of medication–microbiome interactions that affect gut infection 0.72
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III 1.00
5 3.92
Manufacturing-aware generative models enable petascale synthesis of designed DNA 0.96
Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement 0.06
Deep-learning-based virtual screening of antibacterial compounds 0.90
Folding-mediated secretion of pure bispecific antibodies 1.00
Transitive prediction of small-molecule function through alignment of high-content screening resources 1.00
4 2.92
Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma 1.00
Charged molecular glue discovery enabled by targeted degron display 0.77
Enzymatic epimerization of monoterpene indole alkaloids in kratom 0.22
A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs with anticancer activities 0.93
2 0.22
Hetero[3.1.1]propellanes 0.17
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 0.06
74 48.81
Structural characterization of kappa-opioid receptor dimer in complex with two G proteins 0.19
The benchmarking and application of tag-degraders in vivo to validate therapeutic targets 0.06
Phenome-wide analysis of downstream health outcomes following second-line antidiabetic agent prescriptions in All of Us 1.00
Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy 1.00
Dual site targeting of the bacterial 70S ribosome by tetracyclines 1.00
Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets 1.00
Engineering B cells to express fully customizable antibodies with enhanced Fc functions 1.00
Structural and dynamic studies uncover a distinct allosteric modulatory site at the µ-opioid receptor 1.00
Effects of different mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance 1.00
Generation of mixed-valency, modular multispecific antibodies using disulfide-linked Fc–FcγR complexes 1.00
Hidden structural states of proteins revealed by conformer selection 0.80
Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial 1.00
CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic 1.00
Disentangled autoencoding equivariant diffusion model for controlled generation of 3D molecules 0.80
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader 0.03
In vivo metabolic tagging and targeting of circulating red blood cells 1.00
Modifying muscle metabolic dysregulation in inclusion body myositis with pioglitazone: a single-arm trial 1.00
Candesartan cilexetil disrupts methicillin-resistant Staphylococcus aureus membrane and potentiates gentamicin and polymyxin B activity 1.00
Structural dynamics and immunogenicity of the recombinant and outer membrane vesicle-embedded Meningococcal antigen NadA 0.07
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis 1.00
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases 0.20
Supramolecular coiled-coil peptide platform for site-specific antibody drug conjugate engineering 1.00
Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS 1.00
Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1 1.00
Multi-to-uni modal knowledge transfer pre-training for molecular representation learning 0.10
Molecular determinant of low-voltage dependence of human Nav1.7 inactivation revealed by efficacy-based Nav1.7 selective inhibitor 0.11
Counting cells can accurately predict small-molecule bioactivity benchmarks 0.56
Reliable repurposing of the antibody interactome inside the cell 0.13
Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection 0.08
Bioresorbable RFID capsule for assessing medication adherence 1.00
Phase diagrams of pharmaceutical solvates from mechanochemistry 0.17
Photocontrolled trimethoprim PROTACs targeting the eDHFR protein tag 1.00
A practical method for determining the rate of covalent modification of fragments and leads 1.00
An open-source screening platform accelerates discovery of drug combinations 1.00
PhenoProfiler: advancing phenotypic learning for image-based drug discovery 0.30
Semi-inductive dataset construction and framework optimization for practical drug target interaction prediction with ScopeDTI 0.05
FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra 1.00
A randomized phase 2 clinical trial to treat moderate-to-severe plaque psoriasis patients with high-induction dosing of risankizumab 1.00
An astrocytic ensemble at vHip-NAc synapses modulates cognitive impairments induced by chronic tetrahydrocannabinol exposure 0.22
A resource to empirically establish drug exposure records directly from untargeted metabolomics data 0.84
Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies 1.00
Temporally resolved and interpretable machine learning model of GPCR conformational transition 1.00
Structural basis for MEKK2 dimerization and substrate recognition 1.00
Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation 0.09
A large-scale human toxicogenomics resource for drug-induced liver injury prediction 1.00
Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling 0.94
PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors 1.00
Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22 1.00
Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis 1.00
Permeation enhancer-induced membrane defects assist the oral absorption of peptide drugs 1.00
Structural basis of drug recognition by human MATE1 transporter 0.33
AQuaRef: machine learning accelerated quantum refinement of protein structures 0.75
Development of a genetic priority score to predict drug side effects using human genetic evidence 0.75
Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A 1.00
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes 0.32
Extending quantum-mechanical benchmark accuracy to biological ligand-pocket interactions 0.14
Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation 0.94
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome 0.14
Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA 0.43
Harnessing free energy calculations for kinome-wide selectivity in drug discovery campaigns with a Wee1 case study 1.00
Predictive design of crystallographic chiral separation 0.54
Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics 0.52
Data-driven organic solubility prediction at the limit of aleatoric uncertainty 1.00
Simulations and active learning enable efficient identification of an experimentally-validated broad coronavirus inhibitor 0.19
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor 1.00
Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates 1.00
Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors 0.09
Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex 0.36
Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury 0.05
ColdstartCPI: Induced-fit theory-guided DTI predictive model with improved generalization performance 0.11
Clinical impact of pharmacogenetic risk variants in a large chinese cohort 0.00
A biomimetic multi-component subunit vaccine via ratiometric loading of hierarchical hydrogels 1.00
SE(3)-equivariant ternary complex prediction towards target protein degradation 0.25
A genotype-to-drug diffusion model for generation of tailored anti-cancer small molecules 0.17
1 1.00
Real-time dynamic polygenic prediction for streaming data 1.00
6 4.67
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial 0.86
Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals 0.44
Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes 0.94
Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide 1.00
Lifetime Benefits of Comprehensive Medical Therapy in Heart Failure with Mildly Reduced or Preserved Ejection Fraction 0.44
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity 1.00
2 1.18
Cell-free immuno-profiling on a genetically programmed biochip 0.18
Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics 1.00
1 0.47
Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus 0.47
1 1.00
Hypervariable loop profiling decodes sequence determinants of antibody stability 1.00
1 0.08
Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents 0.08
2 1.57
Ophthalmic Drug Shortages in the United States: Survey of the University of Utah Drug Information Service Drug Shortage Database 0.88
Special Report: Recommendations on Screening for Hydroxychloroquine Retinopathy (2026 Revision) 0.69
10 9.43
Functionality-Matched Semicarbazone Reagents Allow Access to X‑ray Quality Crystals and Solids of Diverse Organic Molecules 1.00
Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases 1.00
Studies toward Pestalachloride B: Synthesis of the 6/7/6 Tricyclic Scaffold 1.00
Mechanistic Insights into the Regioselective Defluorofunctionalization of Trifluoromethylanilines via Photocatalytic SET: A Combined Experimental and Computational Study 0.43
Scalable Transannular Bromocyclization Approach to Functionalized Bis-Heterobicyclo[3.n.1]anes 1.00
On-DNA Deoxygenative C(sp2)–C(sp3) Coupling Facilitated by Surfactant–DNA (Surf-DNA) Workflow 1.00
Generation [via Tetradehydro-Diels–Alder Reactions] and Reactivity of 6-Fluorocyclohexa-1,2,4-triene Intermediates 1.00
Surf–DNA-Enabled DNA-Encoded Library-Compatible Amino Radical Transfer C(spsup2/sup)–C(spsup3/sup) Coupling 1.00
Subtle Strain-Release-Driven Aroylation of Four-Membered Rings via Decarboxylative Giese-Type Reactions 1.00
General Approach To Access Aldehyde Oxidase Metabolites of Drug Molecules via N-Oxidation/Reissert–Henze-Type Reaction 1.00
1 0.86
Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans. 0.86
3 1.01
The benefits and risks of maternal RSV vaccination on mortality in South Africa: A modeling study 0.06
Association between proton pump inhibitor use and upper gastrointestinal cancer: A matched case-control study accounting for reverse causation and confounding by indication 0.10
Pediatric studies and labeling additions required by the U.S. FDA for novel drugs approved from 2011 to 2023: A retrospective cohort study 0.86
36 31.92
Rebinding drives cellular retention of small-molecule drugs with abundant targets 1.00
A PKA-selective inhibitor captures an open but more ordered conformation of the PKA catalytic subunit 0.73
Design of an ultrabright biosensor for dynamic imaging of kinase activity in cells 1.00
Energetics of biomolecular shells in core–shell nanocomplexes 1.00
AI-derived therapeutic development of a serotonin receptor–targeting drug for the treatment of opioid use disorder 1.00
Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapies 1.00
Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases 1.00
Fab–Fc and Fab–Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies 1.00
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models 0.93
Mechanical performance of hybrid polymer–lipid vesicles with leaflet asymmetry engineered using microfluidics 0.85
Med14 phosphorylation shapes genomic response to GLP-1 agonists 1.00
Extended local anesthesia enabled by flavonoid permeation enhancers 1.00
Molecular assemblies and pharmacology of cerebellar GABAA receptors 1.00
Neuron-specific modulation of SLC30A10 identifies dopaminergic and glutamatergic neurons as targets of manganese-induced motor disease 1.00
A cytokine receptor–targeting chimera toolbox for expanding extracellular targeted protein degradation 1.00
Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium 1.00
Cannabis produces acute hyperphagia in humans and rodents via increased reward valuation for, and motivation to, acquire food 0.33
Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection 0.71
From sequence to scaffold: Computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks 0.82
Modulating antigen processing through metal–organic frameworks to bias adaptive immunity 1.00
A multivalent nanobody–drug conjugate to prevent and treat influenza virus infections 1.00
Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy 0.93
Dibromocarbene addition to bicyclo[1.1.0]butanes: A facile route to substituted bicyclo[1.1.1]pentanes 0.30
Accessing robust vaccine coformulation stability by single adjuvant detection on a microelectrode 1.00
A generalizable deep learning framework for structure-based protein–ligand affinity ranking 1.00
BTK autoinhibition analyzed by high-throughput swaps of SH2 domains 1.00
Manifold-constrained nucleus-level denoising diffusion model for structure-based drug design 0.50
Graph neural networks for predicting metal–ligand coordination of transition metal complexes 1.00
Influence of the protein corona on hematopoietic stem and progenitor cell uptake and macrophage clearance of membrane-wrapped nanoparticles 1.00
Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus 1.00
Topology and kinetic pathways of colloidosome assembly and disassembly 0.80
Discovery and development of an oral analgesic targeting the α2B adrenoceptor 0.02
Accelerating countermeasure candidate discovery for A-series chemical warfare agent exposure 1.00
Optimization of a sarbecovirus llama nanobody–antigen binding interface via a combined computational and phage display protein engineering approach 1.00
Total synthesis and biological activity of “carbamorphine”: O-to-CH2 replacement in the E-ring of the morphine core structure 1.00
Testicular somatic and germ cell maturation during rhesus macaque development 1.00
4 3.31
A unified platform for nucleoside analog synthesis 0.40
Conformational landscape adaptations enable processive phosphorylation by Src family kinases 1.00
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes 0.91
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition 1.00
19 13.24
Lymph node–targeted DNA engages TBK1/IFN-I–driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs 1.00
Pulmonary neuroendocrine cell–derived exosomes regulate iron homeostasis and oxidative stress in lung neurons 0.83
Mechanistic insights into the therapeutic properties of delta opioid receptor 0.92
Universal progression of structure and dynamics in colloidal nanocrystal gels during salt-accelerated aging 0.94
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia 0.19
In vivo functional profiling and structural characterization of the human GLP1R A316T variant 0.05
AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications 0.75
Scalable manufacturing of multifunctional insect wing membrane via interfacial lase-and-peel strategy 0.15
Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors 1.00
A microneedle device for rapid dermal interstitial fluid sampling 1.00
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion 0.86
Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines 1.00
Lipid nanoparticles for mRNA delivery in brain via systemic administration 1.00
Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM 0.98
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance 0.74
Machine learning-assisted exploration of multidrug-drug administration regimens for organoid arrays 0.02
Developmental Pb exposure increases rate of forgetting on a delayed matching-to-sample task among Mexican children 0.78
Dual-phoretic wireless device for directionally oriented and carrier-free targeted drug delivery 0.02
Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models 1.00
7 6.03
Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice 1.00
Neutrophil-mediated delivery of antibiotics across the tympanic membrane for otitis media treatment in a preclinical model 1.00
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective 1.00
S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models 0.03
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient 1.00
Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis 1.00
Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion 1.00
3 0.41
Benzodiazepine or Z-hypnotic use during pregnancy and risk of psychiatric disorders in children: population based cohort study 0.08
Adherence to legislation and recommendations to publicly post protocols and results of post-authorisation studies registered with European Medicines Agency: cross sectional study 0.25
Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial 0.07
1 1.00
Multiple Molecule λ-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations 1.00
6 3.02
Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial 0.88
Efficacy and safety of rocatinlimab for the treatment of moderate-to-severe atopic dermatitis in ROCKET-IGNITE and ROCKET-HORIZON: two global, double-blind, placebo-controlled, randomised phase 3 clinical trials 0.50
Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study 1.00
Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial 0.38
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial 0.10
Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study 0.17
1 1.00
Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial 1.00
1 0.48
Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study 0.48
1 0.22
Oral contraceptive use and risk of liver cancer: a population-based study, systematic review, and meta-analysis 0.22
6 3.52
Azithromycin for Preschoolers with Wheezing in the Emergency Department 1.00
A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide 0.40
Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis 0.16
Ivermectin to Control Malaria — A Cluster-Randomized Trial 0.14
Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial 0.91
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes 0.92
2 0.23
Cardiopulmonary exercise testing before lung resection surgery: still indicated? Evaluating predictive utility using machine learning 0.13
Identifying azithromycin responders with an individual treatment effect model in COPD 0.10

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