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Citizen-science approaches can help challenge taboos around intimate health topics, amplify underrepresented voices and prioritize women’s involvement in health research; this Perspective considers the key challenges and ingredients for success.
Digitally enabled and decentralized clinical trials could enable large-scale recruitment of diverse participants—but careful consideration of the barriers faced by underserved groups will be crucial to their success.
Cardiology trials continue to under-represent certain population groups relative to disease distribution; this Perspective outlines strategies to foster representativeness and create a research enterprise that meets the needs of people living with cardiovascular disease.
This Perspective calls for inclusion of patients with MASLD and measurement of liver outcomes in cardio–kidney–metabolic trials, when data suggest mechanistically plausible benefits and clinical safety—and outlines considerations for trial design and regulatory approval.
To correct the market failure around pediatric cell and gene therapies, the authors propose a new model to lead late-stage development and commercialize these therapies outside traditional routes.
AI-enabled wellness apps exist in a regulatory gray area and may pose risks if used to manage mental health issues; this Perspective outlines the possible risks to users and the implications for app developers and regulators.
Causal machine learning methods could be used to predict treatment outcomes for subgroups and even individual patients; this Perspective outlines the potential benefits and limitations of the approach, offering practical guidance for appropriate clinical use.
Self-care interventions have the potential to improve health coverage for women while offering greater agency and autonomy, but only if certain barriers—such as stigma and cost—can be overcome.
The unique risks and needs of women in relation to noncommunicable diseases offer myriad opportunities to intervene and prevent disease, but several key barriers to implementation must be addressed.
