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Steatotic liver disease (SLD), which might lead to cirrhosis and hepatocellular carcinoma, is on the rise worldwide. This Expert Recommendation draws on lessons learned to tackle viral hepatitis and proposes a framework for SLD screening and testing policies.
Preclinical models are essential to study disease pathogenesis and test novel treatments. Here, a broad overview of metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models is provided, detailing main features, advances and limitations of in vitro and in vivo models, and how they translate to human disease.
Nutrition and dietary guidelines in gastrointestinal disorders vary in scope, rigour and recommendations, contributing to variations in practice. This Comment identifies nutrition and dietary guidelines for gastrointestinal disorders, namely chronic constipation, irritable bowel syndrome and inflammatory bowel disease, and examines the methodologies used to develop them.
Protein is an essential nutrient in the human diet. This Review explores the fate of dietary protein in the gastrointestinal tract and its influence on colonic health and disease, providing insights into dietary protein metabolism, digestion, absorption, fermentation and the implications for colonic health.
Some of the highlights in the pancreatic cancer field in 2025 include long-term data on personalized neoantigen vaccine approaches in resected pancreatic adenocarcinoma, detailed clinico-genomic analyses of large clinical trial datasets, and therapeutic strategies for early-stage disease.
In this Review, Brown and colleagues describe the latest insights into the role of cholesterol synthesis and metabolism in the gut and liver, and implications in diseases such as metabolic dysfunction-associated steatotic liver disease, hepatocellular carcinoma and colorectal cancer.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease worldwide, with the Middle East and North Africa (MENA) being severely affected. By shifting towards preventive hepatology, MENA can mitigate the rising tide of MASLD and its complications, reduce health system costs and improve patient outcomes.
Acute-on-chronic liver failure (ACLF) is a complex syndrome characterized by acute hepatic decompensation superimposed on pre-existing chronic liver disease or cirrhosis. This Review provides an update on definitions, pathophysiological mechanisms, clinical presentation and management of ACLF.
Glycans are essential components of the gut mucosa that modulate epithelial barrier integrity, host–microbiota interactions and gut immune response. This Review discusses the role of mucosal glycans in gut homeostasis, in intestinal inflammation and their therapeutic potential for inflammatory bowel disease.
