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Interferometric scattering microscopy combined with photoluminescence imaging enables the fast, high-throughput screening of size and quantum yield for thousands of perovskite nanocubes at the single-particle level across their entire life cycle.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

Exfoliated flakes of van der Waals materials embedded in tailored electromagnetic environments can form intrinsic optical self-cavities, but the influence of this effect on their nonlinear optoelectronic properties at THz frequencies remains unexplored. Here, the authors report self-cavity-induced Purcell enhancement of directional edge photocurrents in WTe₂.

Plasma ctDNA testing for FGFR alterations in metastatic urothelial carcinoma shows high concordance with tissue testing and identifies additional patients with actionable alterations. Here, the authors show that clinical uptake of ctDNA FGFR testing can be combined with tissue-based approaches.

Mechanical modulation of protein conformation enables the reversible induction of strong plasmon-coupled circular dichroism in otherwise achiral plasmonic assemblies.

Understanding interfaces at sub-nanometer scales is vital for complex chemical reactions. Here, the authors advance Pattern-enhanced Resonant Soft X-ray Scattering, enabling efficient operando probing of chemical and structural dynamics at solid-liquid interfaces.

Plant-pollinator interactions are vital for food security and ecosystem stability but threatened by climate change. This study shows how warming and drying limit floral diversity, interaction resistance, and resilience for honey bees across Europe.

The authors report on imaging developments of solid-density plasmas and the current filamentation instability by means of the LCLS-XFEL at SLAC. This offers insights on the instability in the solid density region, stimulating new modelling of laser-solid interactions.

An ab initio laser theory is developed to show that exceptional-point lasers can self-generate frequency combs through dynamic population inversion. Notably, the repetition rate of these EP combs is independent of the cavity’s free spectral range.

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics and enhance central nervous system tumor subtype classification.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In metastatic urothelial carcinoma, it has not been established whether circulating tumor DNA (ctDNA) can replace archival primary tissue to assess mutations and biomarkers. Here, the authors show high mutation concordance between ctDNA and tumour tissue, with high consistency in serial samples.

ER membranes tune protein degradation to lipid composition. Using reconstitution approaches, the authors show that the ubiquitin conjugating enzyme UBE2J2 senses lipid packing, modulating its own and partner enzyme activities; together, they integrate lipid saturation and cholesterol signals.

In an open-label phase 2 trial, patients with non-small-cell lung cancer received neoadjuvant anti-PD-1 with or without anti-LAG-3, showing that curative intent surgery after combined blockade of PD-1 and LAG-3 is feasible, and leads to preliminary clinical responses.

The mechanical properties of central nervous system (CNS) scar tissue are considered to contribute to axon regeneration failure. Here, the authors identify members of the small leucine-rich proteoglycan family as modulators of the inhibitory viscoelastic response of CNS lesions.

Analyses of primary and relapse samples of embryonal tumours with multilayered rosettes provide insights into the molecular mechanisms that underlie the development and opportunities for the treatment of this deadly disease.

The secondary bile acid 3β-hydroxy-deoxycholic (isodeoxycholic) acid, produced by gut bacteria, promotes the generation of colonic extrathymic regulatory T cells, whose immunosuppressive activities are known to be essential for intestinal health.

The presence of axion-like dark matter candidates is expected to induce an oscillating magnetic field, enhanced by a ferromagnet. Limits on the electromagnetic coupling strength of axion-like particles are reported over a mass range spanning three decades.

Rare coding variants that reduce the activity of a protein can have a beneficial impact on health. Here, researchers identify rare genetic variants in the CHRNB3 gene that associate with reduced cigarette smoking across diverse populations.

Detecting FGFR3-mutant muscle-invasive and metastatic urothelial cancers (MIBC/mUC) for targeted therapy remains challenging, but clinically important. Here, the authors develop a deep-learning model to detect FGFR3 mutations in MIBC/mUC from routine histopathology slides, allowing for highly sensitive, rapid, and cost-effective pre-screening.

The efficient excitation of atoms using photons is a fundamental step in the control of photon-atom interaction and quantum information protocols. Here the authors show that photons with an exponentially rising envelope excite a single atom efficiently compared to a decaying temporal shape.

Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

An on-chip integrated wavelength demultiplexer designed using an inverse computational algorithm is experimentally demonstrated. 1,300 and 1,550 nm wavelength light is sorted in a device area of just 2.8 × 2.8 μm².

The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Covalent organic frameworks (COFs) are promising materials for separation membranes, but their wide pores prevent selective gas separation through molecular sieving. Here, the authors demonstrate a Metal-organic framework (MOF)-in-COF membrane with a significant enhancement of separation selectivity of hydrogen over other gases.

The self-assembly of colloidal structures at liquid interfaces finds immediate application in industry, such as food and drug encapsulations. Dommersnes et al. develop a technique to manipulate the distribution of colloidal particles adsorbed on drop surfaces under an applied electric field.

Metamaterials enable the control and manipulation of light on subwavelength scales, allowing numerous optical device applications. Here, the authors show the selective excitation of spatially confined modes in an anisotropic hyperbolic metamaterial, based on the photonic spin Hall effect.

A generalized Mott-insulating state is found theoretically starting from a holographic model. The state has features in common with the conventional variety, and upon doping shares striking similarities with the stripe phases found in cuprates.

Authors showcase 3D direct laser writing to fabricate optically interfaced mechanical resonators. The membrane-type structures are placed inside fiber Fabry-Perot cavities to realize a miniaturized optical cavity. Further, the optomechanical properties reveal the coupling mechanism and a significant tuning of the mechanical resonator frequency.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Nature has developed the ability to produce a wide range of optical effects most notably in the butterfly wing. Here, the authors report on the analysis of the structures responsible for ultra-black coloration across different butterflies and combine this with modelling to identify the key characteristics

A miniaturized frequency up-converted electrically tunable single-mode photonic source in the 9.0–10.5 THz range is demonstrated.

The success of allogeneic hematopoietic stem cell transplantation for the treatment of haematological cancers is limited by the morbidity and mortality associated with graft-versus-host disease (GVHD). Here the authors show that the microbial metabolite desaminotyrosine contributes to graft-versus-leukemia responses while protecting against GVHD and promoting mTORC1 and STING-dependent intestinal regeneration.

A deep learning model trained on multiple tumor immune cell stainings from patients with colorectal cancer outperforms currently used clinical and single tumor immune cell staining-based parameters in predicting prognosis. The model can also predict the response to neoadjuvant therapy.

Voltage-modulated scanning probe microscopy may elucidate important processes at solid–liquid interfaces, but it is complicated by the presence of mobile ions. By incorporating force sensitivity into a multidimensional measurement approach, Collins et al.present a technique that overcomes these limitations.

Metastatic castration-resistant prostate cancer is a highly aggressive disease, with a variable response to treatment. Here, the authors validate ctDNA fraction as a poor prognostic factor and develop a model to predict whether patients harbor sufficient ctDNA for informative blood-based genotyping.