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Xeno-learning uses preclinical data from one species to boost the performance of neural networks applied to another species when exploring physiological responses.

Quantum error correction codes protect quantum information, but running algorithms also requires the ability to perform gates on logical qubits. A lattice surgery scheme for fault-tolerant gates has now been demonstrated in a quantum repetition code.

A completely solid-state, single-chip, microwave-frequency surface acoustic wave phonon laser can generate coherent phonons from thermal noise or resonantly amplify injected phonons using only a direct current bias field.

Bringing chiral molecules in contact with metal nanoparticles enables interfacial charge transfer. Here the authors show that when optically resonant, such complexes can show collective chiroptical responses beyond traditional plasmon-exciton coupling.

High-energy interlayer excitons in van der Waals semiconducting transition metal dichalcogenides lie far above the bandgap and emit in the ultraviolet range.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Synthetic dimensions allow photons and gauge fields to interact in photonic emulators. Now a study with fast-gain lasers shows that gain-driven coherence enables robust light flow in frequency space, establishing it as a viable platform for lattice emulation.

Npm1 promotes tumor formation via attenuating the integrated stress response and p53 activation in mouse WNT-driven intestinal and liver tumorigenesis.

When molecules collide with atoms or other molecules their quantum mechanical character can lead to the diffraction of matter waves. Making use of advances in molecular beam technology, such diffraction oscillations have now been observed with unprecedented sharpness and angular resolution in the benchmark NO + He, Ne, or Ar systems.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, such as suppressed gluconeogenesis.

Condensates of excitons have been observed in the quantum Hall regime, but evidence for their existence at low magnetic fields remains controversial. Now evidence of coherence between optically pumped interlayer excitons in MoS₂ marks a step towards confirming exciton condensation at low magnetic fields.

Optoelectronic and photonic devices require materials with multiple, often conflicting functionalities, leading to integration challenges. Here, the authors demonstrate that layered PdSe₂ is suitable for infrared photodetection, light guiding and photothermal applications due to its peculiar semimetallic band structure.

Reducing the fractional uncertainty over the measurement of the frequency of an ensemble of trapped strontium atoms enables observation of the gravitational redshift at the submillimetre scale.

Lung tissue-resident memory T cells (T_RM) are important for controlling respiratory infections, but how they are regulated is still unclear. Here the author compare mouse lung T_RM induced by either intranasal vaccination or direct H1N1 infection to find distinct phenotypes that converge on protecting the mice from H1N1-induced lung pathology.

Controlling nanoscale interfaces is key for ensuring stable plasmonic and catalytic function yet remains difficult to achieve under operando conditions. Now it has been shown that transient Au–Cl adlayers function as redox-active Au(I) intermediates, modulating interfacial electrostatics. This modulation stabilizes gold nanogaps and directs ligand rebinding, thereby enabling reproducible regeneration of subnanometre architectures.

The zebra finch robust nucleus of the arcopallium (RA) directs singing by providing descending projections to brainstem motor neurons. The authors show that electrophysiological characteristics of RA neurons rely on resurgent Na+ currents that emerge early during song development only in males.

Qudits, higher-dimensional analogues of qubits, expand quantum state space for information processing using fewer physical units. Here the authors demonstrate control over a 16-dimensional Hilbert space, equivalent to four qubits, using combined electron-nuclear states of a single Sb donor atom in Si.

Systems combining nucleic acid hybridization with enzymatic catalysis could offer both excellent precision and efficient signal amplification. Here authors develop a system based on “thiol switching”, where specific DNA sequences control enzyme activity – an approach that could have a wide range of applications in biotechnology.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

GRX-810, an oxide dispersion strengthened alloy, shows excellent structural performance above 1100°C and stability up to 1300 °C. Grain-size effects, additive manufacturing–induced anisotropy, and fine trigonal Y₂O₃ particles enhance creep resistance.

The reaction F + H₂ → HF + H is the only source of interstellar HF, but studying it at relevant cold temperatures has proved problematic. Now, the rates of this reaction have been measured at various temperatures down to 11 K and their remarkable agreement with state-of-the-art quantum mechanical calculations has been shown. (Background © Image Asset Management/Alamy)

A materials platform using tantalum as a base layer and silicon as the substrate to construct superconducting qubits enables device performance improvements such as millisecond lifetimes and coherence times, as well as high time-averaged quality factors.

ER membranes tune protein degradation to lipid composition. Using reconstitution approaches, the authors show that the ubiquitin conjugating enzyme UBE2J2 senses lipid packing, modulating its own and partner enzyme activities; together, they integrate lipid saturation and cholesterol signals.

A gene therapy method using AAV can help deliver HIV-fighting antibodies long-term, but the body often rejects them. Here the authors show that a short course of the drug rapamycin helps prevent host anti-drug antibody responses, showing successful antibody delivery in mice and monkeys.

Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for T_reg cell transcriptional and functional programs.

Si color centers offer promising quantum technology applications, but their interaction with electric fields has not been explored. Here the authors report electrical manipulation of telecom emitters in Si by fabricating lateral diodes with an integrated ensemble of G centers in commercial Si on insulator wafer.

GTPase-activating proteins (GAPs) often contain regulatory PH domains. In this work, Soubias et al, using an integrated structure-function approach, discovered a mechanism where a GAP PH domain binds directly to a GTPase to induce allosteric changes facilitating GTP hydrolysis.

Reducing rotational dephasing is a major challenge in ultracold molecules. Here, the authors demonstrate coherent control of three rotational states in ultracold molecules trapped in magic-wavelength optical tweezers, opening prospects towards quantum applications with higher-dimensional systems.

Electrically controlled quantum confinement of excitons to below 10 nm is achieved in a 2D semiconductor by combining in-plane electric fields with interactions between excitons and free charges.

Ultrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser.

Rare-earth elements are effective for engineering the optical properties of materials for a range of applications from lasers to quantum information technologies. Here, the authors investigate the temperature-dependent properties of Er³⁺ photoluminescence in Er₂O₃ thin films, focusing on the Stark-Stark transitions and how their temperature-dependent behaviour results from electron-phonon interactions.

We report an ensemble of cold ⁸⁵Rb atoms strongly coupled to a superconducting resonator and optical cavity, resulting in the demonstration of quantum-enabled transduction of millimetre wave photons to optical photons.

Researchers show that atom-like dipoles based on germanium vacancy centres in diamond may be useful as antennas, exhibiting million-fold near-field optical intensity enhancement. These antennas are used to detect and control the charge state of nearby carbon vacancies.

Trapped ions are promising for studies of atomic and quantum physics, but their need for radiofrequency fields poses numerous technical limitations. Huber et al.present an approach using far-off-resonance optical traps, circumventing radiofrequency fields to improve on photon scattering and recoil heating.

Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action studies identified LolCDE as its molecular target.

THz integrate light sources represent an important building blocks for various applications. Here the authors report an electrically driven topological laser based on photonic Majorana zero mode that can convert electricity directly into THz single-mode laser with topologically nontrivial beams.

The limited routes for polar texture engineering in materials restrict energy efficient applications. Here, the authors establish lattice chemistry control and the use of polarizing surfaces to manipulate electric dipole ordering in thin films.

Quasi-random nanostructures are being considered for many photon management applications but their use has been limited by their costly fabrication. Here, Smith et al. show that the quasi-random patterns on Blu-ray movie discs are already near-optimized for light-trapping applications in solar cells.

Hund’s exchange interaction energy in two-dimensional materials is challenging to extract from experiments. Now, this is achieved in rhombohedral graphene, which allows an estimate of the interactions that drive the variety of correlated states in this material.

State-of-the-art methods for sensing weak AC fields are only efficient in the low frequency domain. Here, Stark et al. demonstrate a sensing scheme that is capable of probing high frequencies through continuous dynamical coupling by applying it to a nitrogen-vacancy centre in diamond.

Stepwise deuteration of protonated methane CH₅⁺ — a fluxional structure that undergoes ‘hydrogen scrambling’ — leads to dramatic changes in the infrared spectra of the isotopologues. The spectra can be assigned using ab initio quantum simulations that account for the non-classical occupation — by H and D atoms — of topologically different sites within the molecule.

By engineering an exceptionally controlled environment using rotationally magic optical tweezers, long-lived entanglement between pairs of molecules using detectable hertz-scale interactions can be achieved.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

Beck et al. develop a model where striosomes create a flexible “decision-space” that adapts to environmental context and internal state. It explains how we make choices and why decision-making varies between people, and in neuropsychiatric disorders.

All-optical logic devices could overcome the speed limitations of conventional electronic devices. Here, authors demonstrate sub-ps all-optical switching exploiting the ultrafast transition from strong to weak light-matter coupling in microcavities with bilayers of transition metal dichalcogenides.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.