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Water-floating nanotransfer printing (WF-nTP) is proposed for transferring nanostructures onto three-dimensional substrates. Using WFnTP, an Au SERS nanomesh for pesticide detection on plants and a Pd-based hydrogen gas sensor are demonstrated.

Hydrogel encapsulation prevents dehydration, but maintaining interfacial stability with hydrophobic shells remains challenging. Here, the authors use a multi-layered marble strategy composed of two hydrophobic particle layers with sandwiched oil layer that stabilizes the interface.

RNA fragments derived from cleaved transfer RNAs play roles in gene regulation and cell proliferation. Here, the authors report that upon ER stress, an ER ribonuclease produces a specific tRNA fragment that promotes cancer cell proliferation and modulates mRNA alternative splicing.

Circuit and cell type prioritization for complex disorders is crucial to direct future efforts. Here the authors integrate GWAS, human single-cell RNA-seq and fMRI analysis suggesting multi-modality convergence on amygdalar and hippocampal circuits.

Nitrogen deposition on forest canopies enhances long-term nitrogen retention in woody biomass, whereas deposition on the understory favors retention in understory vegetation and soil, as demonstrated by a UAV-based nitrogen addition experiment using an isotopic tracer approach.

Li, Wu, Zhou, et al. retrospectively analyze 298 hormone-sensitive prostate cancers with FDG/PSMA dual-tracer PET, linking clinical and imaging metrics to treatment responses. Higher whole-body FDG burden predicts shorter survival and more benefit from chemotherapy, while higher lesional PSMA uptake associates with better radiographic response.

Nanometer-wide lateral heterostructures between 2D semiconductors are still rare. Here the authors report the valley-selective hole state transmission between ferroelectric SnTe monolayers separated by a PbTe barrier with the width of merely 2 nm.

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype with limited effective therapeutic options. Here, the authors identify the RNA-binding protein ELAVL3 as a driver of differentiation into NEPC via a positive feedback loop with MYCN and demonstrate the use of the repurposed drug pyrvinium pamoate to target this axis using preclinical models of NEPC.

Solid-state batteries promise high energy and safety but face challenges in ion transport and scalability. Here, authors develop entropy-driven zwitterionic dry polymer electrolytes enabling scalable, high-energy all-solid-state batteries operating efficiently under practical conditions.

In Vibrio vulnificus, ribosomes containing variable rRNAs encoded by the rrnI operon (I-ribosomes) preferentially translate a subset of mRNAs involved in bacterial adaptation of environmental changes, establishing divergent rRNAs as regulators of gene expression.

The antiferromagnetic moments in the topological insulator/antiferromagnetic insulator bilayer (Bi,Sb)₂Te₃/α-Fe₂O₃ can be reversibly switched using electrical currents at room temperature, and with a critical current density that is one order of magnitude smaller than that required in heavy-metal/magnetic insulator systems.

Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablation in mice induces muscle atrophy which can be rescued by knockown of Actn3 expression.

The authors prepare single-domain SrAl_11-δTiO₁₉ ferroelectric thin films with a magnetoplumbite structure through a solid-state reaction. This thin film not only exhibits high remnant polarization but also demonstrates excellent polarization retention characteristics.

Mechanical properties have potential in biomedical applications, but the mechanical properties are not comparable to load-bearing tissues. Here, the authors report the development of hydrogels composed of hydrogel fibers that assemble to give parallel bundles, formed from polymer-particle agglomerates.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease characterized by an immunosuppressive microenvironment. Here the authors show that a subset of P2RX1-negative neutrophils with immunosuppressive properties accumulate in PDAC metastatic liver tissues and promote tumor growth.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Molecular magnets may provide fundamental building blocks for future spintronic and quantum information technologies. Here, the authors demonstrate how the Yb₄ tetrahedral components of inorganic materials Ba₃Yb₂Zn₅O₁₁behave as isolated molecular magnets.

Electric contacts of semimetallic bismuth on monolayer semiconductors are shown to suppress metal-induced gap states and thus have very low contact resistance and a zero Schottky barrier height.

A hybrid epoxy–acrylate resin is reported for the digital light processing 3D printing of bioinspired metamaterial structures with precisely patterned hard and soft domains.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Achieving diverse neuromorphic functions with ultralow energy consumption in a single device is a major challenge. Here, the authors demonstrate reconfigurable memristors enabling adaptive neuromorphic computing and high-accuracy spatiotemporal signal recognition at attojoule energy scales.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The ferroelectric polarization generally reduces at the domain walls. Here, the authors demonstrate that a huge enhancement (43%) of ferroelectric polarization in ε-Fe₂O₃ in the domain wall with a low bound charge density.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Stable coating of filters with a thin liquid layer enhances adhesion of airborne particulates while maintaining high air permeability, resulting in longer lifetimes and higher efficiency of these filters.