Nature Search

Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles

Unlike neonatal mammalian hearts, adult hearts have limited regenerative capacity. Here, the authors explore the use of extracellular vesicles collected from neonatal hearts flowing damage, explore the difference in protein expression and delivery potential to trigger myocardial repair.

Hanjing Li
Yining Liu
Benzhi Cai
ResearchOpen Access03 Feb 2025
Nature Communications

Volume: 16, P: 1-18
N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

Wenya Ma
Yanan Tian
Benzhi Cai
ResearchOpen Access08 Mar 2024
Nature Communications

Volume: 15, P: 1-19
The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia–reperfusion injury

Cardiac ischemia–reperfusion (I/R) injury represents a key threat to human health. This study reveals that the long noncoding RNA lncRNA-CIRBIL is protective against I/R injury by inhibiting the nuclear translocation of Bclaf1.

Yang Zhang
Xiaofang Zhang
Zhenwei Pan
ResearchOpen Access22 Jan 2021
Nature Communications

Volume: 12, P: 1-15
The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110–NF45 disassembly to promote heart regeneration in mice

Ma et al. identify a highly conserved PIWI-interacting RNA CRAPIR, as a key regulator of cardiomyocyte proliferation and heart repair after myocardial infarction through the PA2G4–NF110–NF45 signaling axis.

Wenya Ma
Hongyang Chen
Benzhi Cai
Research15 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 102-118
LncRNA-LncDACH1 mediated phenotypic switching of smooth muscle cells during neointimal hyperplasia in male arteriovenous fistulas

Arteriovenous fistulas are the most common vascular access points for hemodialysis, but they have a high incidence of postoperative dysfunction, mainly due to excessive neointimal hyperplasia. Here, the author shows that LncDACH1 regulates NIH through the HSP90/ SRPK1/ AKT signaling axis.

Zhaozheng Li
Yao Zhao
Jundong Jiao
ResearchOpen Access03 May 2024
Nature Communications

Volume: 15, P: 1-18
IFN-γ reprograms cardiac microvascular endothelial cells to mediate doxorubicin transport and influences the sensitivity of mice to doxorubicin-induced cardiotoxicity

Haoyu Ji
Wenya Ma
Benzhi Cai
ResearchOpen Access22 Jan 2025
Experimental & Molecular Medicine

Volume: 57, P: 249-263
Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activator 1b (Mob1b)

Xingda Li
Lingmin Zhang
Zhenwei Pan
Research24 Jun 2025
Cell Death & Differentiation

Volume: 32, P: 2384-2398
Targeting LncDACH1 promotes cardiac repair and regeneration after myocardium infarction

Benzhi Cai
Wenya Ma
Baofeng Yang
Research22 Jan 2020
Cell Death & Differentiation

Volume: 27, P: 2158-2175
Cyclin L1 controls cardiomyocyte proliferation and heart repair after injury

Rui Gong
Xinlu Gao
Benzhi Cai
ResearchOpen Access21 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-4
Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration

Rui Gong
Zuke Jiang
Benzhi Cai
ReviewsOpen Access27 Jan 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-11

Search

Filter By:

Search

Quick links