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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The authors propose an asynchronous sublattice distortion mechanism to elucidate the complex phase transitions in HfO₂-based materials. The phase transitions among the orthorhombic, tetragonal, and monoclinic phases are governed by the orientation of the orthorhombic phase.

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Axially chiral arylpyrroles hold significant promise in catalysis, medicinal chemistry and materials science. Here, the authors report a copper-catalyzed dynamic kinetic asymmetric (4 + 1) cyclization enabling atroposelective synthesis of arylpyrroles with single stereogenic axes or 1,2-diaxes from 1,3- enynes and amines.

China’s growing wastewater sector uses substantial water and energy, straining limited resources. This study shows that optimizing treatment processes nationwide could cut 2035 water and energy footprints by up to 25% at modest extra cost.

Controlling mitochondrial ROS has potential to regulate inflammatory responses, however targeting it in macrophages can be difficult. Here, the authors create hybrid membrane extracellular vesicles capable of targeted delivery to macrophages to modulate mitochondrial ROS, promoting diabetic wound healing.

Hongbing Shen, Zuomin Zhou, Yijiang Chen, Zhibin Hu and colleagues report genome-wide association analyses of sporadic non-syndromic congenital heart malformations in Han Chinese populations and identify two risk loci at 1p12 and 4q31.

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

Xue-Jun Zhang, Zhi-Rong Yao and colleagues report a genome-wide association study for atopic dermatitis in the Chinese Han population. They identified two new susceptibility loci at 5q22 and 20q13.

Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations.

Dai Zhang and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify a new susceptibility locus at 11p11.2 and also identify a locus at 6p21-22.1 in the extended MHC region, which has previously been reported to be associated with schizophrenia in individuals of European descent.

Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.

Here, the authors use single-molecule long-read sequencing to decipher the role of structural variations in high-altitude adaptation, finding evidence that an intergenic deletion down-regulates EPAS1 by disrupting a super-enhancer.

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

Au nanowires with an unconventional hexagonal close-packed (4H) phase stabilize the 4H-phase high-entropy alloys grown epitaxially on their surface through a facile chemical synthesis. The resulting core–shell nanostructures demonstrate promising overall water electrolysis performance.

Proton exchange membrane electrolyzers hold promise for ethylamine synthesis from acetonitrile, yet local acidity fosters proton reduction. Here, authors systematically screen metal catalysts, verifying their effectiveness in such electrolyzers.

A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.

Sterically hindered aryl C-glycosides are biologically important, yet their efficient, stereoselective synthesis remains challenging because severe anomeric congestion limits existing glycosyl cross-coupling methods with bulky aryl partners. Here, the authors report a ligand-enabled stereospecific Pd-catalyzed coupling delivering hindered aryl C-glycosides.

The authors observed the electric field-induced generation and manipulation of topological spin textures at the monolayer limit using the topological magneto-optical effect.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

China’s crowded coasts must balance seafood demand with conserving migratory shorebirds that rely on tidal flats along the East Asian–Australasian Flyway. This study suggests that well-managed mariculture feeds shorebirds and limits overharvest, benefiting seafood production and biodiversity.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Ancient DNA can reveal evolutionary and demographic history of a region. Here, the authors analyze ancient human DNA from ShanDong, China to reveal two waves of gene flow from Yellow River populations in the DaWenKou (6-4 kBP) and early dynastic (3.5-1.5 kBP) periods.

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

Mechanically interlocked supramolecular compounds have garnered widespread attention but it remains challenging to investigate topological adjustments in such complicated structures. Here, the authors use a bidentate pyridyl ligand featuring an extended π-conjugated plane for coordination-directed self-assembly to engineer three different kinds of sophisticated complexes.

Here the authors report that intestinal interleukin-22 promotes GLP-1 production through STAT3 signaling in male mice. This mechanism improves glucose regulation in diet-induced obesity and provides insight into the role of IL-22–GLP-1 signaling in metabolic regulation.

CAR-M therapy shows promise for liver fibrosis but limited anti-inflammatory activity reduces efficacy. Here the authors show that TRIM13-engineered, FAP-targeted CAR macrophages sustain anti-inflammatory function and reduce liver fibrosis in mice.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.