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A sufficiently strong magnetic field drives an electron system into the so-called extreme quantum limit. Zhang et al. demonstrate that in this regime, a Dirac semimetal acquires a robust plateau in the thermoelectric Hall conductivity, with a value independent of magnetic field or electron concentration.

Transition metal dichalcogenides exhibit diverse and tunable electronic states. Here the authors reveal a cascade of phase transitions upon increasing hydrostatic pressure in the few-layer 1T’-WS₂, including a re-entrant superconducting phase emerging from a normal state exhibiting anomalous Hall effect.

Theories predict a large thermopower and a quantized thermoelectric Hall conductivity in topological semimetals. Here, the authors observe an ultrahigh longitudinal thermopower and a giant power factor attributed to the quantized thermoelectric Hall effect in a Weyl semimetal TaP.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Zero Hall effect is found in the quantum limit of KHgSb. This observation is attributed to counter-propagating double quantum spin Hall states.

A new type of Hall effect—the layer Hall effect—is produced in a 2D antiferromagnet that does not exhibit any net magnetization.

The development of high-performance magnetic field sensors is important for magnetic sensing and imaging. Here, the authors fabricate Hall sensors from graphene encapsulated in hBN and few-layer graphite, demonstrating high performance over a wide range of temperature and background magnetic field.

A combination of photoemission and scanning tunnelling spectroscopy measurements provide compelling evidence that single layers of 1T'-WTe₂ are a class of quantum spin Hall insulator.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

We show that an insulating bulk state and helical edge state coexist in Bi₄Br₄ and that this coexistence persists up to room temperature.

Thermoelectric devices enable heat-electricity conversion, but achieving a large Nernst effect typically requires strong magnetic fields. Here, the authors demonstrate that YbMnBi₂, with its unique band topology and magnetic order, exhibits a remarkably high anomalous Nernst thermopower among magnetic materials, offering a promising route for efficient transverse thermoelectric applications.

When a topological insulator is coupled with a superconductor, supercurrents arise that—if fully understood—may allow the detection of long-sought Majorana fermions. Here the nature of these supercurrents is further elucidated as they are characterized as non-symmetric and carried by surface states.

In this study, long-read RNA sequencing achieves accurate single-nucleotide polymorphism calling, haplotype phasing and allele-specific expression analysis.

A new platform making use of hexagonal boron nitride interfaced with the molecular superconductor κ-(BEDT-TTF)₂Cu[N(CN)₂]Br is demonstrated for realizing cavity-altered materials, confirmed by magnetic force microscopy and nano-optical measurements.

When interfaced with a current-carrying heavy metal, spin orbit effects can generate a torque on the magnetization of a ferromagnet, understood as a bulk effect. Here, the authors show evidence of an interfacial contribution to such spin orbit torque in O-doped W/CoFeB thin film systems.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

The authors address spin–orbit torques and magnetization switching in MnPd₃/CoFeB hetrostructures.

Natural products contain a range of chemical structures optimized for biological interactions. Fragmenting these compounds could help to combine this diversity with the broad coverage of chemical space offered by fragment-based drug discovery, and help to improve the efficiency with which screening hits can become successful drugs.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Spin-polarized carriers could show an extra Hall component when moving through certain real-space topological spin textures. Here, He et al. report an exchange bias experienced by the topological spin textures living at the interface between a topological insulator and an adjacent antiferromagnet, suggesting a chiral spin texture is induced.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

It remains difficult to distinguish single-Q and multi-Q magnetic states experimentally. Here, Gastiasoro et al. show that the magnetic configuration of an itinerant system can be mapped out to the local density of states near a magnetic impurity, distinguishing unambiguously between single-Q and multi-Qphases.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Group III/nitride semiconductors have been grown epitaxially on the superconductor niobium nitride, allowing the superconductor’s macroscopic quantum effects to be combined with the semiconductors’ electronic, photonic and piezoelectric properties.

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

At sufficiently strong magnetic fields and low temperatures, electrons assume a quasi-one-dimensional quantum state that is challenging to observe. Here, Bhattacharya et al. report on electron transport in lightly-doped single crystals of SrTiO₃deep in this extreme quantum limit.

An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.

Transition metal dichalcogenides offer a platform to study light-matter interaction in atomically thin semiconductors. Here, the authors perform ab initiocalculations to illustrate the possibility of optical control of chiral edge modes, outlining a strategy to manipulate topological states.

Heterostructures formed by the magnetic topological insulator Cr-doped (Bi,Sb)₂Te and the antiferromagnet CrSb are shown to exhibit emergent interfacial magnetic phenomena that can be tuned with the heterostructure geometry.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Age-related macular degeneration (AMD) is a common cause of vision loss with a large genetic risk in older individuals. Here, for a high-risk AMD subtype, the authors identify an association with a chromosome 10 risk region containing a long non-coding RNA.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

The authors demonstrate control of antiferromagnetic order using helical light.

Charge noise degrades the performance of spin qubits hindering scalability. Here the authors engineer the heterogeneous material stack in ²⁸Si/SiGe gate-defined quantum dots, to improve the scattering properties and to reduce charge noise.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Spin qubits in Si/SiGe quantum dots suffer from variability in the valley splitting which will hinder device scalability. Here, by using 3D atomic characterization, the authors explain this variability by random Si and Ge atomic fluctuations and propose a strategy to statistically enhance the valley splitting

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.