Nature Search

Activation and friction in enzymatic loop opening and closing dynamics

Enzymes present loops around active sites whose closing and opening dynamics are essential for its activity. Here the authors unveil the mechanism governing loop motion, showing that it involves an activated conformational rearrangement around a couple of torsional angles taking place under the strong friction exerted by the rest of loop torsions.

Kirill Zinovjev
Paul Guénon
Iñaki Tuñón
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-12
Pace of ecology drives the tempo of visual perception across the animal kingdom

Using phylogenetic comparative methods across 237 species from disparate phyla, the authors show that species with fast-paced ecologies have higher temporal resolution of perception.

Clinton S. Haarlem
Cliodhna Hynes
Kevin Healy
Research24 Feb 2026
Nature Ecology & Evolution

P: 1-9
Molecular origins of internal friction effects on protein-folding rates

The interaction of water molecules with a protein results in a frictional force that influences protein conformational dynamics and folding, though the nature of the protein also influences the friction. Here, the authors use molecular simulations to examine the origin of this protein contribution.

David de Sancho
Anshul Sirur
Robert B. Best
Research02 Jul 2014
Nature Communications

Volume: 5, P: 1-10
Insulin-receptor antibodies mimic a late insulin effect

E. VAN OBBERGHEN
P. M. SPOONER
C. GRUNFELD
Research01 Aug 1979
Nature

Volume: 280, P: 500-502
The collective burst mechanism of angular jumps in liquid water

The collective nature of reorientational dynamics in water remains poorly understood. Here, the authors show that large angular fluctuations require a highly cooperative dynamics involving correlated motion of many water molecules in the hydrogen-bond network that form spatially connected clusters.

Adu Offei-Danso
Uriel N. Morzan
Asja Jelic
ResearchOpen Access11 Mar 2023
Nature Communications

Volume: 14, P: 1-11
The Optical Rotatory Power of Collagen

R. E. BURGE
R. D. HYNES
Research14 Nov 1959
Nature

Volume: 184, P: 1562-1563
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells

Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through the TGFβ1-Smad3-Srsf1 pathway can be targeted to restore tissue repair in aged mice

Yuguo Liu
Svenja C. Schüler
C. Florian Bentzinger
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-18
Fossil isotope evidence for trophic simplification on modern Caribbean reefs

Using nitrogen isotopes from ancient and modern fish otoliths and corals, the study shows Caribbean reef food webs are now 60–70% shorter and functionally less diverse, indicating human-driven trophic simplification and increased risk of collapse.

Jessica A. Lueders-Dumont
Aaron O’Dea
Xingchen Tony Wang
ResearchOpen Access11 Feb 2026
Nature

Volume: 651, P: 967-973
Different rules govern help for cytotoxic T cells and B cells

JACK R. BENNINK
PETER C. DOHERTY
Research01 Dec 1978
Nature

Volume: 276, P: 829-831
A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules

Victor W. Hsu
Lydia C. Yuan
Richard D. Klausner
Research01 Aug 1991
Nature

Volume: 352, P: 441-444
Coexistence of neurofilaments and vimentin in a neurone of adult mouse retina

Ursula C. Dräger
Research12 May 1983
Nature

Volume: 303, P: 169-172
Intact cerebral ventricle as a site for tissue transplantation

JEFFREY M. ROSENSTEIN
MILTON W. BRIGHTMAN
Research02 Nov 1978
Nature

Volume: 276, P: 83-85
Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

Alan Horwitz
Kimberly Duggan
Keith Burridge
Research10 Apr 1986
Nature

Volume: 320, P: 531-533
The chick ovomucoid gene contains at least six intervening sequences

J. F. Catterall
J. P. Stein
B. W. O'Malley
Research01 Mar 1979
Nature

Volume: 278, P: 323-327
Calcium channels in thrombin-activated human platelet membrane

A. Zschauer
C. van Breemen
M. T. Nelson
Research01 Aug 1988
Nature

Volume: 334, P: 703-705
Laparoscopic pyeloplasty in a solitary kidney

This Case Study describes a 40-year-old man who presented with abdominal pain without lower urinary tract symptoms. Following investigations, including abdominal CT and MAG3 renogram, ureteropelvic junction obstruction was confirmed. In this Case Study the diagnostic work-up in this patient and their management with laparoscopic transperitoneal dismembered Anderson–Hynes pyeloplasty is described.

Nauman Zafar
John Leyland
Nimish C Shah
Reviews01 Nov 2007
Nature Clinical Practice Urology

Volume: 4, P: 625-629
Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1⁺ macrophage activation

Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify cellular and molecular changes in the muscle microenvironment during PAD, focusing on endothelial cell–macrophage interactions.

Guillermo Turiel
Thibaut Desgeorges
Katrien De Bock
ResearchOpen Access15 Sept 2025
Nature Cardiovascular Research

Volume: 4, P: 1221-1240
Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation

C Giani
P Casalini
S Ménard
Research03 Aug 1998
Oncogene

Volume: 17, P: 425-432
Biology of Pollution

G. C. WARE
Books & Arts24 Sept 1960
Nature

Volume: 187, P: 1061-1062
Fibroblast-conditioned medium contains cell surface proteins required for cell attachment and spreading

ALBERT J. T. MILLIS
MARIAN HOYLE
Research16 Feb 1978
Nature

Volume: 271, P: 668-669
Aquatic sources and sinks for nitrous oxide

James W. Elkins
Steven C. Wofsy
Warren A. Kaplan
Research19 Oct 1978
Nature

Volume: 275, P: 602-606
Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease

Krishnan Namboori P.K.
Arun Mohan
Ramachandran K.I.
ResearchOpen Access19 May 2010
Nature Precedings

P: 1
Antibodies to gap-junctional protein selectively disrupt junctional communication in the early amphibian embryo

Anne E. Warner
Sarah C. Guthrie
Norton B. Gilula
Research13 Sept 1984
Nature

Volume: 311, P: 127-131
Ligand binding regulates the directed movement of β1 integrins on fibroblasts

Dan P. Felsenfeld
Daniel Choquet
Michael P. Sheetz
Research03 Oct 1996
Nature

Volume: 383, P: 438-440
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

R. Baskaran
L. D. Wood
J. Y. J. Wang
Research29 May 1997
Nature

Volume: 387, P: 516-519
Permo–Triassic and Jurassic ⁴⁰Ar–³⁹Ar ages from Greek ophiolites and associated rocks

J. C. RODDICK
W. E. CAMERON
A. G. SMITH
Research28 Jun 1979
Nature

Volume: 279, P: 788-790
Persistent virulent phages exist across bacterial isolates

The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.

Peter Erdmann Dougherty
Charles Bernard
Lars Hestbjerg Hansen
Research29 Dec 2025
Nature Microbiology

Volume: 11, P: 31-41
Fibronectin–plasma membrane interactions in the adhesion and spreading of hamster fibroblasts

S. D. J. PENA
R. C. HUGHES
Research02 Nov 1978
Nature

Volume: 276, P: 80-83
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis

Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell invasive and metastasis properties through induction of cytoskeletal and transcriptional memory.

Oscar Maiques
Marta C. Sallan
Victoria Sanz-Moreno
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-23
Large-scale analysis of bacterial genomes reveals thousands of lytic phages

Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.

Alexander Perfilyev
Anastasiya Gæde
Thomas Sicheritz-Pontén
ResearchOpen Access29 Dec 2025
Nature Microbiology

Volume: 11, P: 42-52
A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

Kathryn J. H. Robson
Jennifer R. S. Hall
D. J. Weatherall
Research01 Sept 1988
Nature

Volume: 335, P: 79-82
Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

Liver-resident natural killer (NK) cells sustain the dormancy of disseminated breast cancer cells, and a decrease in NK cells and increase in activated hepatic stellate cells is associated with the formation of liver metastases.

Ana Luísa Correia
Joao C. Guimaraes
Mohamed Bentires-Alj
Research02 Jun 2021
Nature

Volume: 594, P: 566-571
Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential

A. Raz
C. Bucana
I. J. Fidler
Research27 Mar 1980
Nature

Volume: 284, P: 363-364
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors show that in conditions of limited glucose or glutamine availability, pancreatic ductal adenocarcinoma cells can use collagen-derived proline to foster the TCA cycle and allow cell survival bothin vitro and in vivo.

Orianne Olivares
Jared R. Mayers
Sophie Vasseur
ResearchOpen Access07 Jul 2017
Nature Communications

Volume: 8, P: 1-14
A model for the unpulsed light from the Crab pulsar

DALE C. FERGUSON
Research01 Mar 1979
Nature

Volume: 278, P: 331-332
Revisiting the factors affecting child trafficking: an empirical study based on the origin areas

Junjun Zhou
Gang Li
Juan Wang
ResearchOpen Access12 Feb 2026
Humanities and Social Sciences Communications

Volume: 13, P: 1-10
Changes in expression of α6/β 4 integrin heterodimer in primary and metastatic breast cancer

PG Natali
MR Nicotra
O Segatto
Research01 Aug 1992
British Journal of Cancer

Volume: 66, P: 318-322
Accelerated re-epithelialization in β₃-integrin-deficient- mice is associated with enhanced TGF-β1 signaling

L E Reynolds
F J Conti
K Hodivala-Dilke
Research16 Jan 2005
Nature Medicine

Volume: 11, P: 167-174
Treatment of Seeds with Ethylmethansulphonate and Diethylsulphate

M. L. BELLI
T. CERVIGNI
Research01 Dec 1964
Nature

Volume: 204, P: 1199-1200
The black hole low-mass X-ray binary V404 Cygni is part of a wide triple

Analysis of the black hole low-mass X-ray binary V404 Cygni shows that it is part of a wide hierarchical triple whose configuration provides evidence that some black holes form with nearly no natal kick.

Kevin B. Burdge
Kareem El-Badry
Andrew Vanderburg
Research23 Oct 2024
Nature

Volume: 635, P: 316-320
Effect of Hyaluronidase on the Mortality from Experimental Burns

EDITH ROSENBERG
C. R. McCOMB
W. R. FRANKS
Research07 Mar 1953
Nature

Volume: 171, P: 431-432
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

Barbara Ensoli
Rita Gendelman
Robert C. Gallo
Research20 Oct 1994
Nature

Volume: 371, P: 674-680
An Early Miocene anthropoid skull from the Chilean Andes

John J. Flynn
André R. Wyss
Carl C. Swisher
Research18 May 1995
Nature

Volume: 375, P: 253
Identification and characterization of a direct activator of a gene transfer agent

Gene transfer agents (GTAs) are ‘domesticated’ bacteriophages that can transfer any genes between bacteria. Here, Paul Fogg identifies a protein that directly regulates transcription of GTA genes and whose expression is in turn controlled by a global cell-cycle regulator and a quorum-sensing regulator.

Paul C. M. Fogg
ResearchOpen Access05 Feb 2019
Nature Communications

Volume: 10, P: 1-10
Catalase Activity of a Crude Enzyme Preparation from Iron-chlorotic Barley (Hordeum vulgaris) Seedlings

SADAO KOTAKA
ALBERT P. KRUEGER
PAUL C. ANDRIESE
Research01 Dec 1964
Nature

Volume: 204, P: 1198-1199
The binary pulsar observed at four radio frequencies

A. G. LYNE
R. T. RITCHINGS
Research18 Aug 1977
Nature

Volume: 268, P: 606-607
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin α_V

Inflammation induces changes in the extracellular matrix density and composition. Fowell and colleagues show that CD4⁺ effector T cells use integrin α_V for interstitial migration on fibronectin in inflamed tissues.

Michael G Overstreet
Alison Gaylo
Deborah J Fowell
Research11 Aug 2013
Nature Immunology

Volume: 14, P: 949-958
Targeting of α_v integrin identifies a core molecular pathway that regulates fibrosis in several organs

Dean Sheppard and his colleagues show that genetic or pharmacological inhibition of α_v integrin signaling ameliorates fibrosis in several solid organs.

Neil C Henderson
Thomas D Arnold
Dean Sheppard
Research10 Nov 2013
Nature Medicine

Volume: 19, P: 1617-1624
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition

Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologous recombination in cancer cells, promoting error-prone DNA repair and enhancing sensitivity to PARP inhibitors.

Siddhartha Mukherjee
Cindy Garda
Arianna Calcinotto
ResearchOpen Access30 Jul 2025
Nature Communications

Volume: 16, P: 1-20
A New Micro-Electrode for Electro-physiological Work

R. A. WEALE
Research31 Mar 1951
Nature

Volume: 167, P: 529-530

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