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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

The authors present resonant inelastic X-ray scattering measurements of the cuprate superconductor La_2−xSr_xCuO₄, observing a quantum-critical scaling collapse. From the critical exponent, they argue that the symmetry of the quantum critical point is enlarged from O(2) to O(4), implying that orders beyond just the charge density wave participate.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

The mechanisms underlying breathing interoception are unclear. Here authors show that distinct forebrain sites synchronize and entrain to breathing during wakefulness, sleep, and external mechanical ventilation, indicating a fundamental interoceptive mechanism for respiratory monitoring.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Immune checkpoint inhibitors combined with chemotherapy have demonstrated significant benefits in treating triple-negative breast cancer (TNBC). In this study, the authors present results from a randomized phase II trial evaluating the platinum-based and DNA-damaging agent carboplatin in combination with nivolumab in patients with metastatic TNBC.

PtSn catalysts are most effective for propane dehydrogenation but structural tunability remains challenging. Now the use of molecular complex precursors unlocks access to subnanometre alloyed PtSn clusters within silicalite-1. The Pt in the clusters undergoes diverse and rapid interconversion among different electronic structures, resulting in high performance and stability.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

A fully phased genome assembly of the sugarcane foundational cultivar POJ2878 reveals extensive subgenome recombination and non-homologous chromosomal rearrangements.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Soil microbes drive ecosystem functions but are vulnerable to environmental stressors triggered by global change. This study reveals that multiple environmental stressors drive community-level restructuring of soil functional microbiomes globally.

Prunus subgenus Cerasus comprises over 70 species with ornamental, edible, and medicinal value. Here, the authors assemble eight genomes from wild and cultivated Cerasus species, construct pangenome together with 13 public genomes, and uncover the evolutionary origin and genetic determinants of flower development.

A gate-tunable magnetization-driven in-plane anomalous Hall effect is realized in a low-symmetry heterostructure of TaIrTe₄ and layered ferromagnetic insulator Cr₂Ge₂Te₆.

In this phase 2 trial, Perez et al. reported the safety of the vitamin D receptor agonist paricalcitol with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma and the pharmacodynamic effects of paricalcitol in fibroblasts and immune cells.

This study reveals that glycogen metabolism is crucial for the sensory activation of POMC neurons, which is necessary for proper feeding behaviour and metabolic health in mice.

The authors derive formulas for topological invariants in time-reversal symmetric spinful superconductors invariant under all symmetry operations for a given space group. The formulas require only the sign of the intra-band pairing and sign of the Fermi velocity at several points on the Fermi surface.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Infiltrating a bifunctional spacer between perovskite grain boundaries enables perovskite solar cells with a certified power conversion efficiency of 27.01%, 90% of which is maintained after over 2,000 h of operation.

Neuropixels Opto probes combine high-density recording sites with optical waveguide-based light emission sites for simultaneous recording of neuronal activity and optogenetic stimulation with blue and/or red light. As demonstrated in the mouse brain, these probes allow the activation or silencing of defined groups of neurons while acquiring high-quality recordings.

Analyses of sequencing data from 75,602 children referred for genetic testing from 2016 to 2025 provide insights on the association between pathogenic germline variants and childhood cancer.

The gut microbial-derived metabolite HMB induces hepatic SNHG9, which suppresses MYC translation via IMP2, thereby derepressing MAS expression. MAS promotes protective autophagy, and HMB supplementation mitigates acetaminophen-induced liver injury.

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

A large multi-ancestry and trans-generational GWAS of gestational diabetes shows that genetic risk largely overlaps with type 2 diabetes, with limited evidence for pregnancy specific effects.

In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this patient population and demonstrating that an epigenetic mechanism of oncogene activation can be successfully targeted with a tyrosine kinase inhibitor.

Brain-wide transcriptomic profiling in mice reveals that reproductive experience remodels the maternal brain by altering dopamine dynamics in the dorsal hippocampal formation, causing dopamine-dependent histone post-translational modifications, and thereby changes in gene expression and behaviour.

How magnetic impurities influence superconductivity and electronic order in kagome metals remains unclear. Now anisotropic Kondo resonances intertwined with the superconducting gap are observed in a magnetically doped kagome superconductor.

New steel capacity expansion is critical for the feasibility of climate targets, as plants operate for decades. Researchers estimate that while existing and planned plants could commit large emissions, strategic investments using climate finance can largely avert this.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

As sea levels rise, coastal ecosystems and economies are threatened by saltwater intrusion and wetland encroachment. These effects are accelerated by coastal agriculture, highlighting the importance of local management interventions.

Hydrogels have potential for applications in a range of environments, but tend to be unstable in high-saline conditions. Here, the authors report the development of a double-network hydrogel that strengthens with swelling in brine, due to the behavior of zwitterionic ion pairs.

As presented at the 2026 ASCO Annual Meeting, in a phase 2 trial that included an exploratory and a pivotal phase, treatment of patients with MET-amplified gastric or gastroesophageal junction adenocarcinoma with the selective MET tyrosine kinase inhibitor savolitinib showed promising clinical efficacy.

Achieving simultaneous gains in power density and operational stability in proton-exchange membranes remains a formidable challenge. Now it has been shown that cation-directed assembly and sequential functionalization enable superprotonic polyanion–organic frameworks to serve as multifunctional fillers, delivering both high performance and durability in hybrid membranes for next-generation fuel cells.

Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its overexpression stimulates autophagic flux, reduces amyloid and tau pathology and delays cognitive decline.

Zhang et al. report a multifunctional molecule to control the growth of quasi-2D perovskite nanocrystals, reducing defects and ion migration. This enables pure-red LEDs with an efficiency of 30.2%, operational stability of 8426 min, and 12.25 cm² devices maintaining above 20% efficiencies.

An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.

The breast cancer intelligent non-invasive diagnosis system (BINDS) integrates multimodal medical imaging data for breast cancer risk assessment and subtype classification, improving diagnostics and reducing the need for biopsies of benign lesions.

β-Arrestins, multifunctional adaptor proteins that regulate G-protein-coupled receptors (GPCRs), form phase-separated condensates, suggesting that β-arrestin liquid–liquid phase separation organizes and diversifies GPCR signalling functions.

Combined single-cell transcriptomic and chromatin accessibility sequencing analysis of mouse primary visual cortex across postnatal development reveals that the glucocorticoid receptor drives astrocyte maturation to limit neuronal plasticity.

A meta-analysis using the Burden of Proof framework, drawing on 16 systematic reviews and 843 observational studies, finds that alcohol consumption increases risk for most health outcomes, with high intake uniformly harmful for all tested outcomes and only limited, outcome-specific U-shaped associations at low-to-moderate levels for some cardiometabolic and neurological conditions.

Ge, Wang, Zhao, Guo et al. report a role for stress granules in suppressing ferroptosis by sequestering ferritin upon irradiation and temozolomide treatment in glioblastoma stem cells, which may potentially be targeted for improved efficacy.

Polygenic risk scores vary with genetic ancestry. Here, the authors develop a framework to calibrate for genetic ancestry in these scores that leverages admixture analysis, separating out the ancestry-specific component of polygenic risk scores.

A wearable ultrasound device is optimized for continuous monitoring of pregnancies.

Authors reveal symmetry-protected topological phonons and strong phonon interactions in the thermoelectric Mg₃Bi_2-xSb_x family, explaining its low thermal conductivity and offering a strategy to engineer heat flow in thermoelectric materials.

Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and disease severity, highlighting potential therapeutic targets.

Hu et al. show that the transmembrane glycoprotein CD98hc in cerebral endothelial cells regulates the integrin–FAK signaling pathway, thereby promoting angiogenesis and maintaining blood–brain barrier integrity.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.

Multilayer capacitors comprising a solid solution of two electrocaloric materials PbSc_0.5Ta_0.5O₃ and PbMg_0.5W_0.5O₃ are shown to maintain high B-site order and latent heat without needing an energetically expensive anneal, enabling efficient refrigeration across room temperature.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.