Nature Search

Viruses, Genes and Cistrons

CARL C. LINDEGREN
Research09 Feb 1963
Nature

Volume: 197, P: 566-568
Day-to-Day Pneumogram Variability

Carl E Hunt
Robert T Brouillette
Linda Klemka
Research01 Feb 1985
Pediatric Research

Volume: 19, P: 174-177
Measurement of Cardiopulmonary Function in Ventilated Neonates with Respiratory Distress Syndrome Using Rebreathing Methodology

Carl L Bose
Edward E Lawson
Mitchell Friedman
Research01 Apr 1986
Pediatric Research

Volume: 20, P: 316-320
Changes of Dehydrogenase Activity during Transneuronal Atrophy

CARL KUPFER
Research05 Oct 1963
Nature

Volume: 200, P: 80-81
Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness

Developing treatments that withstand viral evolution is difficult. Here, the authors design ReconnAb-multimers: broad, highly potent therapeutics linking a non-neutralizing antibody, ACE2, and a multimerization domain to prepare for future pandemics.

Ashley Utz
Matt Armbrust
Peter S. Kim
ResearchOpen Access29 Nov 2025
Nature Communications

Volume: 17, P: 1-14
Reduction by Chlorpromazine of Ulcers due to Acute Starvation in Mice

CARL J. PFEIFFER
GEORGE H. GASS
CLYDE S. SCHWARTZ
Research09 Mar 1963
Nature

Volume: 197, P: 1014-1015
A new look at differentiation of the Earth from melting experiments on the Allende meteorite

Carl B. Agee
Research30 Aug 1990
Nature

Volume: 346, P: 834-837
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Prevention of type 2 diabetes through prediabetes remission without weight loss

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

Arvid Sandforth
Elsa Vazquez Arreola
Reiner Jumpertz von Schwartzenberg
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 3330-3340
Mouse Small eye results from mutations in a paired-like homeobox-containing gene

Robert E. Hill
Jack Favor
Veronica van Heyningen
Research26 Dec 1991
Nature

Volume: 354, P: 522-525
STREAMS guidelines: standards for technical reporting in environmental and host-associated microbiome studies

This Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.

Julia M. Kelliher
Chloe Mirzayi
Emiley A. Eloe-Fadrosh
Reviews01 Dec 2025
Nature Microbiology

Volume: 10, P: 3059-3068
Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene

Robert E. Hill
Jack Favor
Veronica van Heyningen
Amendments and Corrections20 Feb 1992
Nature

Volume: 355, P: 750
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Differential immunity induced by Omicron sublineages in naïve and vaccine breakthrough infections

Noah Brazer
Mary Kate Morris
Charles Y. Chiu
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Here the authors develop a ferritin-based protein nanoparticle vaccine candidate for SARS-CoV-2, and show induction of neutralizing antibodies to variants of concern, including Omicron BQ.1, in non-human primates after initial immunization and a booster dose.

Payton A.-B. Weidenbacher
Mrinmoy Sanyal
Peter S. Kim
ResearchOpen Access17 Apr 2023
Nature Communications

Volume: 14, P: 1-13
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases.

Karsten Boldt
Jeroen van Reeuwijk
Kathy Williamson
ResearchOpen Access13 May 2016
Nature Communications

Volume: 7, P: 1-13
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors

SARS-CoV-2 spike-directed, non-neutralizing antibodies were converted into broad-spectrum inhibitors by conjugation to the SARS-CoV-2 receptor, ACE2, resulting in fusion proteins that target all SARS-CoV-2 variants of concern tested.

Payton A.-B. Weidenbacher
Eric Waltari
Peter S. Kim
ResearchOpen Access08 Sept 2022
Nature Chemical Biology

Volume: 18, P: 1270-1276
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Infection with Omicron after vaccination produces cross-neutralizing antibodies to other variants of concern, whereas this induces a limited response to non-Omicron variants in unvaccinated individuals.

Rahul K. Suryawanshi
Irene P. Chen
Melanie Ott
ResearchOpen Access18 May 2022
Nature

Volume: 607, P: 351-355
Detection of neutralizing antibodies against multiple SARS-CoV-2 strains in dried blood spots using cell-free PCR

Neutralizing antibodies are critical for conferring immunity against SARS-CoV-2. Here, Dahn et al. report a PCR assay termed SONIA (Split-Oligonucleotide Neighboring Inhibition Assay) for measuring neutralizing antibodies against multiple SARS-CoV-2 strains in fingerprick dried blood spot samples.

Kenneth Danh
Donna Grace Karp
Cheng-ting Tsai
ResearchOpen Access21 Jul 2022
Nature Communications

Volume: 13, P: 1-8
Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California

A combined analysis of SARS-CoV-2 viral load and whole-genome sequences from COVID-19 patients, including some who were previously vaccinated, reveals that vaccine breakthrough infections are more commonly associated with antibody-resistant SARS-CoV-2 variants than infections in unvaccinated individuals, and that symptomatic breakthrough infections may be as efficient in spreading COVID-19 as unvaccinated infections.

Venice Servellita
Mary Kate Morris
Charles Y. Chiu
Research10 Jan 2022
Nature Microbiology

Volume: 7, P: 277-288
Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates

Antibody and antibody-avidity assays relying on near-infrared-fluorescence amplification by nanostructured plasmonic gold substrates accurately quantify antibodies to SARS-CoV-2 and to common viruses in human serum and saliva.

Tiancheng Liu
Jessica Hsiung
Hongjie Dai
Research29 Oct 2020
Nature Biomedical Engineering

Volume: 4, P: 1188-1196
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Sheila A Fisher
Mark Tremelling
Jack Satsangi
Research27 Apr 2008
Nature Genetics

Volume: 40, P: 710-712
A DIAGNOSTIC APPROACH TO CHILDREN WITH SUSPECTED OBSTRUCTIVE SLEEP APNEA (OSA)

Robert T Brouillette
Donna Hanson
Carl E Hunt
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 228
Field-grown tobacco plants maintain robust growth while accumulating large quantities of a bacterial cellulase in chloroplasts

Expression of heterologous proteins from plastid genomes can compromise plant growth. However, field-grown tobacco plants overproducing a bacterial cellulase suffer no loss in biomass or Rubisco content and little reduction in photosynthesis.

Jennifer A. Schmidt
Justin M. McGrath
Beth A. Ahner
Research08 Jul 2019
Nature Plants

Volume: 5, P: 715-721
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Over 170 susceptibility loci have been identified by genome-wide association studies in breast cancer. Here, the authors interrogated the role of risk-associated variants from non-breast tissue, and using expression quantitative trait loci, identify potential target genes of known breast cancer susceptibility variants, as well as 11 regions not previously known to be associated with breast cancer risk.

Manuel A. Ferreira
Eric R. Gamazon
Georgia Chenevix-Trench
ResearchOpen Access15 Apr 2019
Nature Communications

Volume: 10, P: 1-18
The evolution and population diversity of human-specific segmental duplications

Segmental duplications in the genome are regions with the potential for the evolution of phenotypic novelties, but their cataloguing has been technically difficult. Here, the evolution and function of human duplications is characterized.

Megan Y. Dennis
Lana Harshman
Evan E. Eichler
Research17 Feb 2017
Nature Ecology & Evolution

Volume: 1, P: 1-10
Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Payton A.-B. Weidenbacher
Mrinmoy Sanyal
Peter S. Kim
Amendments and CorrectionsOpen Access05 Oct 2023
Nature Communications

Volume: 14, P: 1
The Immunogenicity of Haemophilus influenzae Type B Conjugate Vaccines in Children Born to HIV-Infected Women † 899

Jennifer S Read
Carl E Frasch
Mary Glenn Fowler
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 155
Excess of rare, inherited truncating mutations in autism

Evan Eichler and colleagues analyze the relative impact of de novo and rare, inherited variants on autism risk. They show a statistically independent role for rare, inherited mutations and implicate several new candidate genes likely contributing to autism risk.

Niklas Krumm
Tychele N Turner
Evan E Eichler
Research11 May 2015
Nature Genetics

Volume: 47, P: 582-588
Expression of the lymphotoxin β receptor on follicular stromal cells in human lymphoid tissues

Marianne Murphy
Barbara N Walter
Lois B Epstein
Research01 Jun 1998
Cell Death & Differentiation

Volume: 5, P: 497-505
Non-viral vectors for chimeric antigen receptor immunotherapy

Non-viral vectors offer scalable, cost-effective alternatives for chimeric antigen receptor T cell therapy. In this Primer, Tretbar et al. highlight advances in the use of non-viral approaches, gene delivery methods, clinical outcomes and key considerations for translating these technologies into practice.

U. Sandy Tretbar
Joel G. Rurik
Ulrich Blache
Reviews10 Oct 2024
Nature Reviews Methods Primers

Volume: 4, P: 1-19
Further evidence supporting a potential role for ADH1B in obesity

Liza D. Morales
Douglas T. Cromack
Christopher P. Jenkinson
ResearchOpen Access21 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Social distancing and extremely preterm births in the initial COVID-19 pandemic period

Vivek V. Shukla
Benjamin A. Carper
Kathryn D. Woodbury
ResearchOpen Access22 Feb 2024
Journal of Perinatology

Volume: 44, P: 1050-1057
Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study

Amin Emad
Saurabh Sinha
ResearchOpen Access08 Feb 2021
npj Systems Biology and Applications

Volume: 7, P: 1-14
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

Exome sequencing on a large cohort of parent–child trios with sporadic autism spectrum disorders shows that de novo point mutations are mainly paternal in origin and positively correlate with paternal age, and identifies a highly interconnected network formed from the products of the most severe mutations.

Brian J. O’Roak
Laura Vives
Evan E. Eichler
Research04 Apr 2012
Nature

Volume: 485, P: 246-250
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R. Barnes
Matti A. Rookus
Antonis C. Antoniou
ResearchOpen Access15 Jul 2020
Genetics in Medicine

Volume: 22, P: 1653-1666
Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial

Ira Adams-Chapman
Kristi L. Watterberg
Marian Willinger
Research23 Mar 2021
Journal of Perinatology

Volume: 41, P: 2072-2087
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants

Taru A. Muranen
Anna Morra
Heli Nevanlinna
ResearchOpen Access12 May 2023
npj Breast Cancer

Volume: 9, P: 1-15
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive uptake, and that inducing lysobisphosphatidic acid in late endosomes or blocking EV recycling enhance AZD4785 activity in cells with poor productive uptake, potentially offering improved treatment strategies.

Alexander N. Kapustin
Paul Davey
Sanyogitta Puri
ResearchOpen Access01 Nov 2021
Communications Biology

Volume: 4, P: 1-13
A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia

Grace MacDonald
Andrea Sitlinger
David B. Bartlett
ResearchOpen Access30 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Charles E. Green
Jon E. Tyson
Kimberlee Weaver-Lewis
ResearchOpen Access04 Aug 2023
Journal of Perinatology

Volume: 43, P: 1398-1405
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
A genotype-first approach identifies an intellectual disability-overweight syndrome caused by PHIP haploinsufficiency

Sandra Jansen
Alexander Hoischen
Bert B. A. de Vries
Research05 Dec 2017
European Journal of Human Genetics

Volume: 26, P: 54-63

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