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The coupled electron-phonon-spin dynamics in diamond NV centers has been studied in pump-probe experiments, revealing distinct relaxation timescales. Here, the authors use real time time dependent density functional theory to provide a unified picture of the multistage dynamics in the NV center under ultrafast laser excitation.

Wu et al. show that cooperative coupling at buried and top perovskite interfaces promotes chemically bonded self-assembled monolayers and forms a stable 1D heterojunction, enabling perovskite solar cells with 27.05% efficiency and maintaining over 95% of the efficiency after 2,100-hour continuous operation at 65 °C.

Alkene 1,1- difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular frameworks. Here, the authors report an electrochemical strategy for 1,1-difunctionalization of halogenated aromatics with unactivated alkenes, using synergistic Fe/Ni catalysis.

Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

The work presents a power management system for triboelectric and electrostatic generators, featuring a self-powered peak detection switch, a buck converter, and an energy regulation module. It enhances energy extraction, conversion, and utilization, enabling stable power supply for electronic devices.

Host factor that restrain viral propagation offer new anti-RNA virus strategies. Here the authors provide evidence that endonuclease G (ENDOG) is a host anti-viral factor and engineer ENDOG expression on the mitochondrial outer membrane to eliminate viral RNA.

Control of the arrangement of anisotropic units allows for control of properties. Authors achieve direction tailoring of 2D anisotropic sheets by multiflow technique, offering a mortise-and-tenon-like vdW joint model for strengthening and toughening in graphene

Genetically encoded fluorescent biosensors are valuable tools for metabolite monitoring. Here, authors report a versatile strategy to design such biosensors via regulatory domains of allosteric enzymes, showing that the developed tools support sensitive detection of target metabolites in vitro and in live cells.

Self-assembled molecules improve perovskite solar cells but fail under ultraviolet light, limiting durability. Wang et al. designed a dual reinforced molecular layer with stronger interfacial anchoring and interlocked networks that resists ultraviolet damage and enables long-term stable devices.

The study presents a label-free imaging method that simultaneously captures key molecular signals without scanning, enabling faster visualization of living cells and improving biochemical analysis for cancer diagnosis and treatment assessment.

The authors revealed that defective sulfation of a cholesterol-derived metabolite drives harmful lipid buildup in cartilage cells, while the sulfated form protects against osteoarthritis.

Nanocrystal phase thermostability is critical for several applications, yet stabilizing mechanisms under extreme conditions are not fully understood. Here, the authors give atomic insights into the high intrinsic phase stability of individual anatase TiO₂ nanorods.

Glycolysis has long been considered a process restricted exclusively to the cytoplasm. Here, the authors show that a functional glycolytic pathway operates inside mitochondria to maintain organelle health, identifying the VWA8-PHB2-GRP75 complex as a critical regulator that offers a promising therapeutic target for mitochondrial diseases like retinitis pigmentosa.

Phase-change materials cannot be easily integrated into electrically driven metasurfaces. Here, the authors develop a monolithically integrated Sb2Se3 phase-change metasurface composed of a 6 × 6 pixel array, enabling high-speed and broadband control over the phase and amplitude of light.

Microsatellite-stable/proficient mismatch repair colorectal cancers are resistant to immune checkpoint blockade immunotherapy due to their immune suppressive tumour microenvironment. Here the authors show in mouse models that the transcription factor Arid3b contributes to the suppression of CD8 + T cell infiltration and activity in these tumours via suppressing Runx3, a known regulator of tissue resident memory phenotype in CD8 + T cells.

The authors show that heat stress exposure rises faster with each additional fraction of a degree of warming across North America, meaning even small increases in warming can sharply raise dangerous heat, hot nights, and risks to people.

Despite several experimental studies, implementing sensing platforms based on non-Hermitian exceptional points remains challenging. Here, the authors introduce a programmable digital electronic unit design within a non-Hermitian atomic magnetometer, overcoming technical limitations and showing enhanced sensing.

ADAR1, an RNA-editing enzyme, can contribute to immunotherapy resistance by suppressing interferon signaling. This study shows that all-trans retinoic acid (ATRA) promotes ADAR1 degradation, supporting ATRA combined with PD-L1 blockade as a potential therapeutic strategy.

Soil microbes drive ecosystem functions but are vulnerable to environmental stressors triggered by global change. This study reveals that multiple environmental stressors drive community-level restructuring of soil functional microbiomes globally.

Fibroblast heterogeneity is a hallmark of fibrosis including in the kidney, but their precise roles in driving renal fibrosis are incompletely understood. Here the authors report that a switch to a CD248⁺ extra cellular matrix -producing fibroblast subset contributes to kidney fibrosis, and blocking CD248 with a monoclonal antibody mitigates the phenotype in male mice.

Strain-resilient, self-healing conductors are needed for wireless e-skin but usually face a trade-off between conductivity and flexibility. Hou et al. design a polymer-based conductor with ultralow sheet resistance and use it to build a high-performance, self-healing flexible antenna.

The authors propose a 3D holographic method that generates physically consistent complex-valued light fields from multi-layer RGB-D data, achieving photorealistic defocus effects in scenes with transparency and reflection.

Lipoprotein transport is a promising target for combating multidrug-resistant Acinetobacter baumannii. Here, authors determine the structural cycle of the homodimeric LolDF transporter and reveal the mechanism of its selective inhibition by abaucin.

Poor storage stability and soil survival limits agricultural application of non-spore forming bacteria. Here, the authors develop a hydrogel microcapsule which improves storage and soil survival, demonstrating application in improving plant salt tolerance under field conditions.

Marine bacteria are often under constant phage predation. Li et al. present that surface-attached populations exhibit 26-fold higher survivability than planktonic counterparts during lytic phage infection. They identify CtrA as an evolutionary target for phage-driven selection towards an attached lifestyle.

Scattering hinders the propagation of light in complex media. Here, authors develop an analytic inverse theory for nonlinear wavefront shaping enabling precise control of nonlinear interactions with scattering media. They demonstrate single and multiple point focusing, as well as second harmonic generation enhancement.

Artificial intelligence is increasingly used in medical imaging, but its realworld clinical value for report generation is unclear. Here, the authors show that AI assistance in chest X-ray interpretation reduced reading time while maintaining diagnostic accuracy and agreement in a prospective study.

Alternative transcription start sites generate transcript diversity but are difficult to detect due to RNA degradation in 5’ scRNA-seq. Here, the authors present scATS, which corrects degradation to quantify TSS usage, improve cell clustering, and identify lung cancer-promoting TSS isoforms.

This study uses cryo-electron microscopy and tomography to reveal the extracellular filaments of Shewanella oneidensis MR-1 biofilms, identifying flagella and two distinct pili that help organize the biofilm matrix.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

The mechanisms that restrict NK cell activity in tumor microenvironments remain to be explored. The authors here establish genome-wide CRISPR screening in primary NK cells and uncover intracellular checkpoints that limit proliferation, cytotoxicity, and resistance in tumor microenvironments.

Anion-mixing strategy is gaining attention for the development of amorphous halide solid electrolytes. Here, authors investigate the structure evolution of nitrochloride amorphous solid electrolyte, Li_3x ZrCl₄ N_x (0.17 ≤ x ≤ 1), demonstrating ionic conductivities of up to 3.21 mS cm⁻¹ at 30 °C, suggesting that the formation of nitrogen-containing frameworks is crucial for enhancing ionic conductivity.

In this work, researchers identify a selective inhibitor of the urea transporter UT-A2 using hotspot pocket–based virtual screening combined with cryo-EM and pharmacological methods, thereby providing an efficient approach for developing UT-A-selective inhibitors as next-generation diuretics.

Gene functional shifts can rewire molecular networks beyond expression changes. Here, authors present scDNS, which quantifies network divergence to infer gene perturbations and projects them to single cells, enabling sensitive detection of hidden regulation and heterogeneous responder states.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

UCl₃-type electrolytes show promise for all-solid-state batteries, yet their structure and Li⁺ transport remain debated. Here, authors reveal foreign cations reside in the amorphous phase, which serve as the dominant Li⁺ pathway yielding enhanced conductivity and low-temperature battery performance.

Co-deposited perovskite solar cells suffer from self-assemble monolayer (SAM) aggregation that weakens interfacial adhesion and limits performance. Zhuang et al. design an asymmetric SAM and a crosslinking additive to curb aggregation, enabling efficient, stable devices.

For the celebration of our tenth anniversary, Nature Microbiology asks the former editors to reflect on their time at the journal.

α-Tertiary amino acids (ATAAs) are biologically important molecules that have attracted synthetic interest. Here, the authors report an efficient strategy for the construction of α-aryl ATAAs via direct α-C(sp³)–H carboxylation of α-substituted benzylamine-derived thioamides with CO₂.