Search

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

The superconducting diode effect describes non-reciprocal transport of the superconducting current and there is focus on how to engineer and apply this property practically. Here, the authors utilise a heterostructure to implement a dual-mode superconducting diode effect, where dissipationless current flows along a single direction, that can be activated by both out-of-plane and in-plane magnetic field. The dual modes share similar diode efficiency but requires different magnitude of magnetic field to be operated.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

A dual-action force dynamics strategy using a hard silicon template as a nanoimprinting stamp combined with inverted transfer printing is described for the manufacture of high-performance full-colour ultrahigh-resolution quantum dot light-emitting diodes (LEDs) for active-matrix displays, while revealing electric-field reconstruction in nanoscale arrays and introducing dielectric matching to mitigate field concentration and performance degradation.

The behavior of rollers in viscoelastic fluids is not well understood, despite their potential applications in micro-scale actuation systems and targeted cargo delivery. This study demonstrates that rollers can exhibit a backward sliding motion when rolling in viscoelastic fluids, revealing a net backward viscoelastic stress that surpasses the forward frictional force.

Wearable neuromorphic optoelectronics require advanced dynamic perception and multifunctional integration. Here, authors develop intrinsically stretchable neuromorphic visual adaptive transistors with simpler structure and improved performance with adaptive time down to 0.4 s.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Alphaherpesvirus infections pose a health challenge due to the lack of effective broad-spectrum antiviral strategies. Here, the authors identify a broadly neutralizing antibody, 16F9, which targets glycoprotein B, offering cross-protection against multiple viruses and demonstrating robust efficacy in mouse models, paving the way for antiviral interventions.

The amination of C(sp3)–H bonds is an appealing and challenging task in organic synthesis. Here, by using an electrogenerated sulfate radical an HAT agent, the authors report a practical Ritter-type amination of C(sp3)–H bonds.

Metal nanoclusters are promising for flexible light-emitting diodes but face efficiency and stability challenges. Here, the authors employ a π-conjugated mediator to align dipole alignment, yielding devices with 26.4% external quantum efficiency and 94% efficiency retention after 2000 bending cycles.

The authors demonstrate a TEMPO-mediated urotropine electrosynthesis that is accelerated by defective carbon, as the vacancy defects transfer the oxidation of TEMPOH from a sluggish outer sphere process into a rapid inner sphere mechanism via adsorption.

Mutation detection in cfDNA is crucial for cancer diagnosis and monitoring. Here, the authors develop an Enzymatic Cleavage-directed Single Nucleotide Variant Sequencing by integrating Argonaute-mediated cleavage and stem-loop DNA-initiated PCR amplification for cfDNA mutation detection.

H5N1 avian influenza viruses can be highly pathogenic. Here, the authors show that H5N1 infection leads to increased serum levels of angiotensin II in patients and mice, and that administration of angiotensin-converting enzyme 2 ameliorates lung injury in infected mice.

Understanding the risks of bystander and off-target editing is essential for genome engineering applications. Here, the authors analyze the fidelity of adenine and cytosine base editors in vivo.

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

While it is possible to synthesize two-dimensional covalent organic frameworks with reversible stacking phases and thus pore sizes, it is challenging because the slipped AA-stacking is the most thermodynamically stable phase. Here, the authors report shape memory 2D covalent organic frameworks with reversible interlayer stacking sequences.

Here, the authors demonstrate that CXCL5 expression is increased in ankle joints of gouty arthritis model mice. CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and joint inflammation.

Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses

A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

Three-dimensional multiplane structured illumination microscopy, combining three-beam interference, multiplane detection and a synergistically evolved reconstruction algorithm, enables 3D imaging at rates of up to 11 volumes per second in live cells with lateral and axial spatial resolutions of 120 and 300 nm, respectively.

An unconventional machine learning-based inverse design framework enables the generation of ultrabroadband and band-selective thermal meta-emitters with complex 3D architectures and diverse material compositions.

Alterations in cholesterol homeostasis may contribute to hepatic cancer aggressiveness. Liu, Tian, and Zhang et al. identify the long non-coding RNA SNHG6 as an important player in this process by linking cholesterol sensing with cancer cell growth through mTORC1 signaling.

The role of outer mitochondrial membrane proteins in Myocardial Ischemia-reperfusion Injury (MIRI) largely remains unknown. Here, the authors demonstrate that the outer mitochondrial membrane protein Myocardial Mitochondrial Antiviral Signaling (MAVS) protein promotes MIRI suggesting MAVS protein as potential therapeutic target.

The advancement of sodium halide solid-state electrolytes can propel high-energy-density all-solid-state sodium-ion batteries. Here, the authors present a LaCl₃-based electrolyte facilitating rapid Na⁺ ion conduction along the c-axis diffusion channel, ensuring high capacity even at elevated current densities.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Here, the authors show that intravital NIR-II bone imaging is effective in diagnosis of a series of common bone diseases non-invasively in mice.

Human motions often contain information that is useful for orthopedic/neural disease diagnosis, rehabilitation, and prevention. Here, the authors show a badge-reel-like stretch sensing device with a grating-structured triboelectric nanogenerator for joints/spine bending or stretching sensing.

Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.

The authors combine the strong confinement of hyperbolic polaritons with leaky nano-waveguides to demonstrate directional in-plane emission of fast phonon polaritons and their acceleration and deceleration by tailoring waveguide dispersion.

Energy density and cyclability are often a trade-off for lithium-ion batteries. The authors develop cobalt- and nickel-free cathodes with both good cycling stability and high energy density through the integration of polyanion units into rocksalt structures.

Kaposi’s sarcoma-associated herpesvirus changes mitochondrial architecture via vBcl-2 interaction with a host NDP kinase, which triggers mitochondrial fission and inhibition of MAVS allowing for virus production.

Thermogenic adipocytes are ideal targets to counteract obesity and associated metabolic disorders. Here, the authors show a regulatory role of linker histone variant H1.2 on iWAT browning and thermogenesis through an H1.2-IL10rα axis.

FD-DeepLoc uses field-dependent deep learning for precise localization of spatially variant point emitters over the full chip of a modern sCMOS camera, enabling fast and high-throughput volumetric localization microscopy.

Here, using fecal metagenomics data of 2,320 individuals, the authors develop a microbiome-based machine learning approach showing high accuracy for multi-class disease diagnosis, highlighting its potential application in improving noninvasive diagnostics and monitor responses to therapy.

The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.

Arrays of horizontally aligned carbon nanotubes are promising candidates for advanced integrated circuits. Here, the authors present a nano-seeding method that enables direct growth of such arrays on one-inch wafers with a density up to 140 tubes per μm.