Search

Chronic non-healing wounds infected with antibiotic-resistant bacteria present a growing global health challenge. Here, Han et al. develop high-entropy alloy-based Janus artificial enzymes with pH-gated redox biocatalysis for sequential therapy of drug-resistant bacteria and inflammatory wounds.

A bioelectronic device incorporating triphylite (LiFePO₄) as electrode is used for lithium-ion-specific inhibition of peripheral and central nervous system activities in rats and in mice.

The chromatin remodeler BRAHMA (BRM) is found as a repressor of plant adaptation to acid stress by inhibiting the STOP1-NRT1.1 signaling module. Under low pH, BRM degradation activates nitrate uptake and alkalinizes the rhizosphere.

Modelling suggests the carbon cost for nitrogen assimilation by plants will rise substantially under future climate change with further increase at higher latitudes, due partly to enhanced contributions of soil inorganic nitrogen.

This study reports that visible-light-excited TAPP aggregates generate highly reductive electrons ( − 2.68 V vs NHE) to cleave PFAS C–F bonds without additives, enabling a sustainable strategy for practical PFAS remediation in contaminated water.

The formation of alkoxyl boronate complexes in cross-coupling reactions typically undergo classical transmetallation followed by reductive elimination to form C–C and C–X bonds. Here, the authors report an iridium-catalyzed asymmetric alkylation that enables the stereoselective construction of cis-cyclobutanes, employing the high ring strain of bicyclo[1.1.0]butane-derived boronate complexes to induce 1,2-alkoxy migration.

Reverse water-gas shift is key for CO₂ use, but high-temperature surface reconstruction obscures structure-performance links. Here, metastable MoO_x on Mo₂N gives equilibrium-level CO₂ conversion and 99% CO selectivity at 500 °C.

Pseudorotaxane dethreading offers a means to regulate motion in artificial molecular machines but achieving predictable and programmable control over dethreading kinetics remains challenging. Here, the authors report systematic modulation of dethreading behaviour through component engineering of a pseudorotaxane platform.

Total water storage in Eurasia can be driven by both climate variability and human activities, with the latter suggested as the key factor for water loss. However, here the authors show that drying in the low-latitude Atlantic Ocean is the dominant force in storage depeletion during 2003-2017.

Accurately describing and tuning active sites remains a major challenge. Here, the authors introduce an effective metal-ion chelation strategy—guided by DFT predictions and in situ Raman measurements—to structurally engineer and quantitatively link the electronic properties of active sites in an ionic liquid.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

The authors report the mechanical stress-induced dielectric strength weakening of hBN nanosheets with thinner nanosheets showing more remarkable weakening, as evidenced by lower breakdown strength, shorter breakdown time, and larger leakage current.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Doping a metal nanocluster with heteroatoms dramatically changes its properties, but it remains difficult to dope with single-atom control. Here, the authors devise a strategy to dope single atoms of Ag or Cu into hollow Au nanoclusters, creating precise alloy nanoparticles atom-by-atom.

Elebsiran plus PEG-IFNα improved hepatitis B surface antigen (HBsAg) loss rates compared with PEG-IFNα alone in patients with chronic hepatitis B virus infection. Furthermore, prior response to the BRII-179 vaccine was associated with higher HBsAg clearance, suggesting its potential as a predictive tool for identifying patients more likely to benefit from therapies.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

Trans-organ analysis of gene co-expression networks in different tissues provides a unique method for uncovering long-distance regulation.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

The antidiabetic drug acarbose is shown to be degraded by a Klebsiella species present in the human gut, which is enriched with acarbose treatment and might mediate acarbose resistance and variations in clinical efficacy observed in patients.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

In situ mechanical testing and simulations unveil a reversible shuffle twinning mechanism enabled by bond switching, which gives rise to anisotropic tensile superelasticity in GeSe ceramics.

A microphase crosslinking strategy, leveraging aziridine-based crosslinkers, is used to render organic thermoelectric materials stretchable and elastic.

The authors demonstrate that salt stress activates CDK8, which phosphorylates AHL10 and promotes its degradation. AHL10 is involved in recruiting SUVH2/9 to repress salt-responsive genes. The CDK8-AHL10-SUVH2/9 module is critical for transcriptional dynamics in response to salt stress.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

An ultra-flexible cylindrical mesh embedding multiple electrodes bending away from the device is used to probe rodents’ neural activity in vivo. This geometry improves the neuron–probe contact and reduces tissue response in chronic applications.

Deformation twinning, a key deformation mechanism that is rarely explored in superhard materials, is shown to be activated in cubic boron nitride and other cubic covalent materials under a loading-specific twinning criterion.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.