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Genetic variants can influence the expression levels of proteins in different diseases. Here, the authors examine the blood proteome in common diseases to identify genetic variants associated with protein levels, and improve risk prediction.

Aqueous-hydrotrope hybrid liquid electrolyte solutions enable overcoming the electrochemical stability window and operational temperature limits of aqueous electrolyte solutions in secondary zinc-based batteries, also improving the battery performance.

Catalysts enhance electrode reactions in static batteries but are inadequate for aqueous flow batteries. Here, authors develop carbon quantum dot catalytic electrolytes that function both in electrolyte and at-interface to improve reaction kinetics and low-temperature adaptability in Zn-Br systems.

Arousal-modulating neural circuitry remains enigmatic. Here, authors show that the pathway, glutamatergic ventral pallidal neuron→locus coeruleus noradrenergic neuron→the lateral hypothalamus, controls arousal in awake and anesthetized states.

Xu et al. establish the importance of H2A.Z in mouse oocyte development. H2A.Z is incorporated into chromatin at promoters and putative enhancers, and its presence promotes histone acetylation in fully grown oocytes.

Novel Cas protein discovery is vital in CRISPR-Cas technology. Here, authors develop AIL-Scan, an AI-assisted Cas detection strategy using the ESM model, and discover seven unreported Cas12a subtypes with distinct DNA cleavage and PAM recognition, enabling SNP detection and precise gene editing.

Aqueous zinc-iodine flow batteries show potential in large-scale storage but face water imbalance-induced instability. Here, authors develop a tailored ionic-molecular sieve membrane that selectively intercepts hydrated ions, enabling stable high-capacity long cycling with low projected costs.

Materials for wearable energy storage devices should be mechanically durable. Here, the authors report a supercapacitor composed of polyacrylic acid dual cross-linked by hydrogen bonding and vinyl hybrid silica nanoparticles which is self-healable and retains performance when stretched up to 600%.

After alloying with metal cations, a lead-free halide double perovskite shows stable performance and remarkably efficient white-light emission, with possible applications in lighting and display technologies.

SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.

Zn batteries suffer from low voltage due to the high redox potential of the Zn anode and the low potential of traditional cathodes. Here, the authors develop a polymer hetero-electrolyte, which allows separated Zn and Li reversibility and achieves a 2.4 V-Zn battery based on the LiNi_0.5Mn_1.5O₄ cathode.

A CRISPR–Cas9 screen identifies genes that modulate long interspersed nuclear element-1 (LINE-1) expression in human cells. LINE-1 5′ UTRs have enhancer features and can activate long-range gene expression, including during zygotic genome activation.

The development of porous membranes that could work under high power density brings promise but a challenge with polyiodide cross-over for aqueous Zn-I flow batteries. Here, the authors develop a colloidal starch-based catholyte to inhibit cross-over that endows reversible flow cell performance.

Migrasomes are recently discovered extracellular vesicles that are produced during cellular migration. Here, the authors show that macrophage-derived migrasomes are implicated in the progression of cerebral amyloid angiopathy (CAA) through increased complement signaling using skin biopsies from CAA patients and CAA mouse models.

Maternal SETD2 deficiency leads to loss of H3K36me3, aberrant DNA methylation and ectopic H3K4me3 and H3K27me3 in mouse oocytes. Maternal depletion of SETD2 causes oocyte defects and subsequent zygotic arrest.

The performances of rechargeable batteries are detrimentally affected by low temperatures (e.g., < 0 °C). Here, the authors report a few-layer Bi2Se3 material capable of improving battery cycling performances when operational temperatures are shifted from +25 °C to −20 °C.

Research on electrochemical nitrate reduction to ammonia in acidic conditions has been less extensive than that conducted in alkaline conditions. Here, the authors report a hybrid of iron phthalocyanine and TiO₂ catalyst with improved efficiency toward acidic nitrate reduction and its application in Zn-nitrate batteries and high-voltage pollutes-based fuel cell.

Cells lacking TET proteins and DNMT3A and DNMT3B show that DNMT1 has imprecise maintenance activity and weak de novo activity leading to spontaneous ‘epimutations’. These epimutations can be corrected through a neighbor-guided mechanism.

Cl-redox reactions cannot be fully exploited in batteries because of the Cl2 gas evolution. Here, reversible high-energy interhalogen reactions are demonstrated by using a iodine-based cathode in combination with a Zn anode and a Cl-containing aqueous electrolyte solution.

While Zinc anodes are thermodynamically unstable in aqueous solutions, the protons (H+) from the water favor the cathodes of Zinc batteries. Here, the authors address this contradiction by designing an asymmetric electrolyte composed of an inorganic solid-state electrolyte and a hydrogel electrolyte.

Here the authors pull apart the cellular composition of the tumor microenvironment using RNA sequencing data from a wide variety of cancer types. They identify immunity quantitative trait loci and integrate these data with analysis of colorectal cancer cohorts, creating a polygenic risk score and a database for community access.

The interactions between water molecules, electrode materials and anions are essential yet challenging for aqueous dual ion batteries. Here, the authors demonstrate the voltage manipulation of dual ion batteries through matching intercalation energy and solvation energy of different anions.

Binding of RNA polymerase II during zygotic genome activation in mouse embryos is determined using the newly developed method Stacc–seq.

Naoki Irie and colleagues report the draft genomes of the soft-shell and green sea turtles. Their genome-wide phylogenetic analysis supports the hypothesis that turtles are a sister group of crocodilians and birds.

Anion effects can be well tuned to effectively improve their electrochemical performances in many aspects. This Review highlights the considerable effects of anions on surface and interface chemistry, mass transfer kinetics and solvation sheath structure across various energy storage devices.

Dramatic innovations in surface and bulk chemistry enable MXenes to flourish in electrochemical applications. This Review analyses the recorded footprints of MXene components for energy storage, with particular attention paid to a coherent understanding of the fundamental relationship between MXene components and their qualified roles from a nuanced chemical perspective.