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Zhang et al. report a multifunctional molecule to control the growth of quasi-2D perovskite nanocrystals, reducing defects and ion migration. This enables pure-red LEDs with an efficiency of 30.2%, operational stability of 8426 min, and 12.25 cm² devices maintaining above 20% efficiencies.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

Urban green spaces are linked to better human health, however whether lant species heterogeneity also influences better health outcomes remains unclear. Here, Zhao et al., propose the beta-diversity hypothesis, using data from 72 neighborhoods across Shanghai.

Gate residues, acting in concert with distal dynamic networks, are important yet underexploited regulators of enzymatic catalysis. Here, the authors report conformational dynamics analysis of fluoroacetate dehalogenase RPA1163, which reveals a gate-based allosteric pair (K181–W185) that governs substrate access and reactivity, and engineer this pair to obtain a highly active variant for turnover of α-fluorophenylpropionic acid.

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

Recent work has shown that structural disorder is a key descriptor of capacitance in nanoporous carbons. Here, the authors demonstrate that low-temperature synthesis produces carbons with smaller graphene-like domains and higher ion adsorption capacity, leading to enhanced capacitance.

The authors provide a spatial transcriptomic atlas of cynomolgus monkey embryos at Carnegie stages 9 and 10 and further do comparative analyses using public human and mouse data to dissect conserved and species-specific transcriptional programs.

Direct regeneration of spent lithium-ion battery positive electrode materials is hindered by structural disorder and surface degradation. Here, authors use oxidation to reconstruct lithium transport pathways and regenerate dense single-crystal LiNi_0.5Co_0.2Mn_0.3O₂ with stable cycling performance.

Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global forests, potentially explaining why this intricate phenomenon cannot be adequately explained by pairwise interactions alone.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

By tuning graphene’s electronic density of states, the study shows electrode electronic structure—not just the electrolyte—dominates reorganization energy and thus controls outer-sphere electron-transfer rates at solid–liquid interfaces.

This study found COVID-19 vaccination offers added protection against reinfection in children and adolescents with prior infection but variable effectiveness across variants. Findings support vaccination benefits beyond infection-acquired immunity.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

The authors performed computational and experimental analyses to reveal how Smoothened directly inhibits PKA through an intrinsically disordered region, defining a central step in Hedgehog signaling and a mechanism of G-protein-coupled receptor–kinase regulation.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Many hospitalised children with acute illness in low- and middle-income countries experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. Here the authors report multiomic profiling to investigate biological drivers of hospital in-patient and post-discharge mortality in 3,101 acutely ill children across nine sites in sub-Saharan Africa and South Asia.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

Measures of persistent organic pollutant concentrations in human pancreas remain limited; additionally, no studies have correlated pollutant concentrations with direct measures of beta cell function in humans. Here the authors show that lipophilic pollutants—including dioxins/furans, polychlorinated biphenyls, and organochlorine pesticides— accumulate in human pancreas and positively correlate with markers of beta cell dysfunction.

The effects of global biodiversity loss on local plant communities have been equivocal. Across 57,398 European time series, covering > 100 years, local plant diversity gains are often associated with rises in generalist and non-native plants.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implications for how these orally delivered weight-loss drugs engage brain reward circuits.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

The experimental observation of a fundamentally new type of anomalous Hall effect that couples both in-plane and out-of-plane orbital magnetizations in multilayer rhombohedral graphene is reported.

This study uses genome-wide screening and mouse genetics to uncover how cells control proinsulin, identifying the Golgi as a central hub and revealing PDIA6 as a key regulator of proinsulin production in pancreatic β-cells.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

RNA velocity is a widely used method to predict the fate of single cells. Here the authors show that the concept can be adapted to predict the fate of individual human subjects, using RNA velocity of whole blood at a single point in time to predict future clinical outcomes and treatment responses.

FILM is a mid-infrared photothermal microscopy variant that involves optical boxcar demodulation-based illumination, denoising and spectral deconvolution. Its relatively gentle nature allows imaging of metabolic processes in organelles in cell culture as well as in Caenorhabditis elegans.

In this individual participant data meta-analysis, and across 321,345 smartphone-ratings of affective well-being and nearly 1 million hours of physical activity measurement, Rehder et al. clarify the nature and extent of activity–well-being relations and document their relevance in humans’ everyday life.

Turning PET plastic waste into useful chemicals usually takes several steps and makes mixtures. This study uses a cobalt catalyst to directly convert PET into high yields of two valuable products, with good stability and lower emissions.

A new approach to magnetic resonance imaging, ‘multiplexed magnetic resonance imaging’, is reported, which enables high-resolution simultaneous multiparametric mapping of multiple molecules in standard clinical settings.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse models via synergistic incretin and PPAR activity.

Among sorbents used in atmospheric water harvesting, hydrogel salt-composites show exceptional performance at a low cost, but their durability remains unexplored. Here the authors systematically study hydrogel-salt composite degradation and its mechanisms under different conditions.

The NeuSMRT platform enables neutrophil-specific CAR expression in vitro and in vivo. These CAR-neutrophils in turn offer robust antitumour effects in humanized and syngeneic mouse models of glioblastoma.

James Webb Space Telescope observations show powerful high-redshift quasar outflows, supporting quasar feedback as a key mechanism driving rapid star-formation quenching in early massive galaxies.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

A self-localized, ultrafast pencil beam can be readily introduced into multiphoton microscopes and applied for near-diffraction-limited, high-throughput volumetric imaging in intact tissues and in vitro models.

Nanozymes are promising for controlling plant bacterial diseases, but conventional nanozymes suffer from low bacterial affinity, inefficient enzyme-like activity, and thus poor antibacterial efficacy. Here, the authors report a copper single-atom nanozyme that outperforms commercial thiodiazole copper in controlling plant bacterial diseases via intelligent capture and photo-enhanced activity.

Methane is a potent greenhouse gas, but can also be used as a source for advanced carbon materials. This work shows a sustainable approach to produce high-value carbon fibres through methane pyrolysis.

Methods that can map the influence of ligands on target genes across spatial niches are still necessary to improve our understanding of tissue microenvironments. Here, the authors develop Renoir, a method to infer ligand-target activities and map them to spatial niches in spatial transcriptomics data, with applications in fetal liver and hepatocellular carcinoma cells.

National parochialism is the tendency to cooperate more with people of the same nation. In a 42-nations study, the authors show that national parochialism is a pervasive phenomenon, present to a similar degree across all the studied nations, and occurs both when decisions are private or public.

A paired electrolysis strategy enables efficient C–N coupling between lignin and various nitrogen sources (nitroaromatics and nitrogen oxides), paving the way for using renewable lignin to produce high-value nitrogen-containing aromatics.

Multi-ancestry and ancestry-stratified genome-wide analyses identify genetic variants associated with refractive error and enable construction of an enhanced polygenic predictor incorporating functional annotations.

Poholek and colleagues show that allergic alarmin-induced IL-9 increases expression of the transcriptional repressor Blimp-1 in ILC2 cells, sustaining their cellular identity and type 2 immune responses.