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Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathways.

Predicting gene expression from H&E slides is a cost-effective alternative to Spatial Transcriptomics for clinical use. Here the authors introduce a Multiple Instance Learning approach to infer single-cell expression, unlike prior methods which operate at coarser patch level.

SmartEM is a ‘smart’ pipeline for electron microscopy-based data acquisition for connectomics. In order to efficiently image large datasets, the approach involves imaging at short pixel dwell times and identifying problematic regions that are then imaged with longer dwell times and therefore higher quality.

GlyContact enables systematic analysis of glycan 3D structures, revealing how structural properties like flexibility and surface accessibility determine lectin binding and introducing AI models to predict structural features directly from sequences.

CaMKII is a key enzyme in brain, heart, and egg cells, regulated by calcium signals. Here, authors show that charged residues in the variable linker tune CaMKII activity, a mechanism that may underlie cell type–specific responses.

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Through next-generation spectral analysis, scientists have uncovered an evolutionary path for Wolf–Rayet stars in metal-poor environments. Characterized by hard ionizing radiation, these stars challenge current assumptions about massive star evolution.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best known for its structural support of nuclear periphery – in the control of replication fork restart throughout the nucleus, by supporting heterochromatin establishment and ADP ribosylation levels at replication factories.

Suture zones are abundant on Antarctic ice shelves and widely observed to impede fracture propagation. Here we show that fracture detainment is principally controlled by the zones’ enhanced seawater contents, reducing fracture-driving stresses by orders of magnitude and therefore greatly enhancing stability.

CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.

Fragile X syndrome is a neurodevelopmental disorder caused by inactivating the RNA-binding protein FMRP. Here, the authors show that FMRP acutely regulates structural plasticity in mature adult pacemaker neurons in the Drosophila central brain.

An extreme flare has been seen from a supermassive black hole at redshift z = 2.6. First detected in 2018, it is 30 times brighter than similar events. The most likely cause is the shredding of a star of 30 solar masses or more.

Analysis of data from multiple instruments reveals a giant exoplanet in orbit around the 0.2-solar-mass star TOI-6894. The existence of this exoplanetary system challenges assumptions about planet formation and it is an excellent target for atmospheric characterization.

Although there is extensive theory predicting the effects of population bottlenecks on mutation load, there is little empirical evidence from recent bottlenecks. Here, Grossen et al. compare the consequences of population bottlenecks in six ibex species for genome-wide variation and mutation load.

This study uses radio-echo sounding measurements, ice-core data and models to map the spatial variation in ice-crystal orientation in the northeast Greenland Ice Stream and shows how it potentially affects the ice-flow dynamics in this region.

An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.

A rhynchocephalian skeleton around 3–7 million years older than the oldest currently known lepidosaur fossil provides important insight into the origin of lizards and snakes.

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.

Confocal microscopy enables high-resolution, high-plex 3D cyclic immunofluorescence of 30- to 50-µm-thick tissue sections. The approach allows for rich phenotypic assessments of intact cells and intercellular interactions with subcellular resolution.

Monolayer graphene can support the quantum Hall effect up to room temperature. Here, the authors provide evidence that graphene encapsulated in hexagonal boron nitride realizes a novel transport regime where dissipation in the quantum Hall phase is mediated predominantly by electron-phonon scattering rather than disorder scattering.

Wildfire risk in California’s WUI is rising. Analysis of past events shows home hardening and defensible space can reduce structure loss by up to 52%, but coordinated, community-scale action is essential to maximize impact.

The world needs to move towards an approach to measure well-being rather than economic growth. Here’s how that can happen.

The selective hydrogenation of trace acetylene to ethylene is a well-established process for purifying fossil-derived ethylene streams. Here, the authors present a self-repairing Pd-C laterally condensed catalyst that improves selectivity, prevents sub-surface hydride formation, and achieves high ethylene productivity, effectively bridging the gap between powder catalysts and single-crystal model catalysts.

Analogous to photonic crystals, phononic crystals can be used to engineer the acoustic properties of a system, however, creating nonlinear phononic crystals or nonlinear acoustic metamaterial is challenging. Here, Midtvedt et al.propose periodically pinned, atomically thin membranes as a nonlinear phononics platform.

Whole-genome sequencing identifies a rare missense variant in IKBKB associated with high risk of cutaneous and systemic lupus erythematosus among people with African ancestry.

The consequences of postprandial IL-1β surges in white adipose tissue are unknown. Here the authors show IL-1β regulates WAT remodelling by promoting adipogenesis and energy storage, which is blocked by chronic elevation of this cytokine (as in obesity).

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

In this study, the authors report that post-vaccination neutralizing and binding antibody levels in the ENSEMBLE trial associate with Ad26.COV2.S vaccine efficacy (VE) against severe-critical COVID-19, with substantial VE even at unquantifiable neutralizing antibody titer.

Current intracortical brain-computer interfaces are subject to recording interface instabilities that degrade decoding performance. Here, the authors present a platform for Nonlinear Manifold Alignment with Dynamics (NoMAD), which stabilizes decoding using models of dynamics for at least 3 months.

How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists’ forecasts were on average no more accurate than those of simple statistical models.

Characterisation of quantum operations is fundamental in quantum technologies - quantum computing in particular - but there’s currently no reliably efficient method to assess mid-circuit measurements, which are a key component for subfields like quantum error correction. Here, the authors fill this gap, integrating MCMs into the framework of randomized benchmarking.

Imaging live cells at nanometre resolution is challenging because radiation damage kills the cells during exposure. Here, the authors overcome this difficulty in a ‘diffraction before destruction’ experiment using an X-ray laser and record signal to 4 nm resolution on a free-flying cell.

The SPECULOOS project detected an Earth-sized planet in a short orbit around a nearby Jupiter-sized star. This planet, SPECULOOS-3 b, is one of the most promising rocky exoplanets for detailed emission spectroscopy characterization with JWST.

A 142-qubit processor can be realized by connecting two smaller quantum processors using classical communications and circuit cutting.

Does the transition from foraging to farming result in people working harder? Dyble et al. show that among traditional foragers from the Philippines, greater engagement in agriculture is associated with more time spent working and less leisure time.

Working memory requires the brain to switch between cognitive states and activity patterns. Here, the authors show that the steering of these neural network dynamics is influenced by dopamine D1- and D2-receptor function and altered in schizophrenia.