Search

An alternative mating system, termed parasex, produces progeny with high levels of genotypic diversity and is able to fulfil the roles of meiosis when it is absent in the fungal pathobiont Candida albicans.

The moon Phobos is spiralling inwards towards its disintegration to eventually form a ring around Mars from which new moons may form. Simulations suggest that this is just the latest of multiple ring–moon cycles over the history of Mars.

Viral proteins can achieve high multifunctionality, but mechanisms are poorly understood. This study shows structural flexibility of rabies virus P protein enables RNA binding and phase separation to expand functions by infiltrating host condensates.

JWST observed helium and water in the atmosphere of the giant planet WASP-107 b, revealing a vast outflow of gas and evidence for recent inward migration. The findings shed light on how giant planets lose mass and evolve over time.

Reoviridae undergo a complex assembly pathway in the host cell. Here the authors use cryo-electron tomography to visualize the assembly stages of mammalian orthoreovirus revealing a single shelled intermediate with gross similarity to an early assembly stage of a family of prokaryotic dsRNA viruses.

A giant planet candidate roughly the size of Jupiter but more than 14 times as massive is observed by TESS and other instruments to be transiting the white dwarf star WD 1856+534.

Here, the authors present the cryo-EM structure of the archaeal virus SH1 at 3.8 Å resolution and show how the major capsid proteins assemble into hetero-hexamers, providing insights into the assembly process of this and related PRD1-adeno lineage viruses.

The radial-velocity technique could detect a small gas giant orbiting a binary star and determine its mass: 65.2 ± 11.8 Earth masses. The system also hosts a smaller inner planet, making it one of the few known multiplanetary circumbinary systems.

SLC35B1, initially thought to be a nucleotide sugar transporter, is an essential ATP/ADP exchanger that imports ATP into the endoplasmic reticulum through a unique stepwise translocation mechanism.

Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of macropinocytosis in a context of metabolic stress.

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Multiresolution computational simulations generate all-atom models of a complete packaged virus particle.

Cytoplasmic flows in the fruit fly oocyte can reorganize cellular components. These structured vortical flows arise through self-organizing dynamics of microtubules, molecular motors and cytoplasm.

A transiting planet with a period of about 8.5 days and a radius 0.4 times that of Jupiter is reported within the debris disk around the star AU Microscopii.

A time-resolved cryogenic electron microscopy analysis provides structural information on the processes of primary and secondary nucleation of tau amyloid formation, with implications for the development of new therapies.

The atmospheres of white dwarfs often contain elements heavier than helium, even though these elements would be expected to settle into the stars’ interiors; observations of the white dwarf WD 1145+017 suggest that disintegrating rocky bodies are orbiting the star, perhaps contributing heavy elements to its atmosphere.

A copper oxide high-temperature superconductor magnet generates a direct-current magnetic field of 45.5 tesla—the highest value reported so far—using a design that enables operation at high current densities.

Understanding the fundamental mechanisms of photocurrent generation is important for photodetector design. Now, the anisotropy of the thermal properties of Weyl semimetals is shown to generate circulating photocurrents.

Mapping the operational chemical, physical and electronic structure of an oxygen evolution electrocatalyst at the nanoscale links the properties of the material with the observed oxygen evolution activity.

A fluidic system with spatially reconfigurable hot spots generated by optical pumping of plasmonic nanorods is demonstrated, creating virtual barriers by generating local heating via photothermal conversion, for potential applications in chemical synthesis, lab-on-chip devices and microbiology.

Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function and coordinate blood vessel repair following stroke.

PIN transporters are key players in distributing phenoxyacetic acid herbicides. Mutagenesis and cryo-EM structures elucidate substrate specificity and transport mechanisms, paving the way for improved synthetic auxin development and herbicide-resistant crops.

Using Kepler, this study identifies a compact multiplanetary system that is not flat, where gravitational interactions cause its planets’ periods to change by nearly a day per cycle and their orbital planes to tilt back and forth.

NHA2 exchanges sodium ions for protons across cell membranes, and its activity is linked to the pathogenesis of diabetes mellitus and essential hypertension in humans. Drew et al. report the cryo-EM structure of NHA2 in detergent and nanodiscs.

Light-responsive polymers with polarization-dependent deformation are promising material to develop tunable devices usually limited by irreversible dynamic control. Here, the authors use controlled polarization of visible light to produce arbitrary deformations into amorphous composites containing azopolymer microdomains to unlock the next level of complex actuation in soft lightdriven robots.

A chip-integrated laser with 7.5 × 10⁻¹⁴ fractional frequency instability is demonstrated by active stabilization to an on-chip 6.1-m-long spiral resonator. By using this laser to interrogate the narrow-linewidth transition of ⁸⁸Sr⁺, a clock instability averaging down as \(3.9\times 1{0}^{-14}/\sqrt{\tau }\) is achieved.

The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of identities.

The immunoglobulin domain framework of antibodies has been a long standing design challenge. Here, the authors describe design rules for tailoring these domains and show they can be accurately designed, de novo, with high stability and the ability to scaffold functional loops.

Since publication of the first issue of Nature Reviews Nephrology 20 years ago, advances across various subspecialities of nephrology have provided insights into disease processes and led to the development of new therapeutics for people with kidney disease. However, despite this progress, many kidney diseases remain untreatable, the costs of kidney disease care are immense, and vast inequities persist in disease burden and access to care. In this Viewpoint, we ask experts from several key subspecialties of nephrology to reflect on progress made over the past 20 years, remaining challenges and the steps needed to move the field forward.

Using viral capsid architectures as template for design, higher triangulation number nanocages that require symmetry breaking offer potential advances in targeted delivery and antigen-displaying vaccines.

This study reports clusters of ipsilateral eye preferring neurons in layer 4 of mouse visual cortex, extending into layer 2/3 and upper layer 5. This column-like pattern for ocular dominance expands our understanding of the functional organization in neocortex.

Time-series observations from the JWST of the transiting exoplanet WASP-39b show gaseous water in the planet’s atmosphere and place an upper limit on the abundance of methane.

Acquired drug resistance is common during chemotherapy. Here, the authors describe the structural basis and molecular mechanism by which allosteric and clinically approved, ATP-competitive inhibitors of EGFR synergize to overcome resistance in lung cancer.

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

CarH is a bacterial B₁₂-binding photoreceptor involved in transcriptional regulation. Here, the authors provide insights into B₁₂ dynamics and associated cobalt redox changes following light activation. These demonstrate the CarH response integrates light and oxygen sensing.

Synthetic nanocages that can adapt the size and shape of their cavity in response to a given guest have potential applications in various areas, including chemical purification. Now a flexible, pseudo-cubic metal–organic cage has been developed that is able to dynamically expand its cavity from 46% to 154% of its initial volume by flipping its cage faces.

Structures of separase in complex with either securin or cyclin B–CDK1 shed light on the regulation of chromosome separation during the cell cycle.