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The Star of David topology is an iconic symbol that has been used in religious and cultural contexts for thousands of years. Now it is assembled in molecular form through a hexameric circular helicate generated by six tris(bipyridine) ligands entwined about six iron(II) cations. The structure of the two triply-entwined 114-membered rings is revealed by X-ray crystallography.

Scholz omitted crucial parts of the the recent history of the seismic gap forecast and test. He remarked that our test of the gap theory was 'flawed' because it used earthquakes 'smaller than system-sized'. This was also asserted in a published comment by Nishenko & Sykes¹ and answered by Jackson & Kagan². But 'system-sized' was never defined in the original seismic gap model³.

Local graph estimation can be used to recover interpretable substructures around target variables in large datasets. Here, authors propose pathwise feature selection (PFS) with The editor’s summary is accurate. finite-sample false discovery control, outperforming global methods across diverse applications.

The authors propose and experimentally demonstrate a new route to passive super-resolution fluorescence microscopy inspired by quantum parameter estimation theory, which does not require sequential photoswitching of the fluorophores.

Based on cryo-EM structures, here the authors propose three models for how the inner kinetochore and CENP-A nucleosomes are organized on repetitive alpha-satellite sequences, providing insights into the higher-order architecture of human centromeres.

Epidemiologist who traced roots of chronic disease to early life.

Palaeobiologist who pioneered mathematical modelling of mass extinctions.

Crystallographer who pioneered methods of X-ray imaging and modern computing.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Neuroscientist who helped to reveal how the brain processes visual information.

This study reveals that the divergent Plasmodium NEK4 kinase acts as a central regulator of early post-zygotic meiosis. It couples crucial cytoskeletal reorganisation, such as MTOC duplication and nuclear migration, with chromosomal dynamics to drive meiotic entry and parasite development.

The study introduces FMOPhore, a computational tool that identifies key binding site residues to improve drug design by guiding efficient fragment growth and lead optimization across diverse protein targets.

Using inbred medaka strains, the authors mapped 59 genetic loci linked to heart rate. Gene editing validated conserved genes affecting heart rate and morphology, highlighting the power of isogenic strains in uncovering mechanisms of cardiac traits and disease.

H3K27-altered diffuse midline gliomas are a highly aggressive form of paediatric brain cancer. Here, the authors present molecular profiling of 68 patients, and show the efficacy of precision-guided therapy based on this profiling.

‘Populations residing near nuclear power plants may experience low-level chronic exposure to ionizing radiation through environmental release pathways. In here the authors find higher cancer mortality rates in U.S. counties closer to operational nuclear power plants, with the strongest relative risks observed in older adults.’

Protein synthesis is tightly regulated by the integrated stress response, but therapeutic activation remains challenging. Here, the authors identify a drug‑like allosteric inhibitor, an ISRAC, that stabilises inactive eIF2B, mimicking stress‑induced eIF2α phosphorylation to activate the ISR, establishing eIF2B as a tractable target for ISR modulation.

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.

Cell migration depends on controlled adhesion turnover, but its regulation remains unclear. Here the authors show that AAK1 promotes focal adhesion disassembly via PDLIM5 and Talin1 phosphorylation, enabling efficient cell migration.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Oropouche virus (OROV) is an emerging virus in Latin America. Here the authors show in a mouse model that OROV infects the placenta and can reach the fetus during pregnancy, a conserved feature across ancestral and recent strains that highlights emerging risks to maternal and fetal health.

Chemically induced dimerization (CID) systems allow control over cellular processes. Here, the authors present a proof-of-principle demonstration that a complete CID system can be de novo designed, reporting a designed ligand and protein pair where a protein homodimer is induced by a macrocyclic peptide.

Regulation of replication fork speed is vital for genome integrity. Here, the authors show that limiting TOP2A levels in early S phase induces topological stress and fork slowing whereas TOP2A overexpression accelerates replication while enhancing genome stability.

The authors show that fine features of respiratory cycles, in particular airflow pauses, track the hippocampal network dynamics, microarousals and noradrenergic fluctuations that underlie sleep architecture. Breathing thus provides a window into brain–body interactions

Accumulation of abnormal tau protein selectively affects specific brain cell populations in tau-related dementias. Here, the authors use single nuclei data to show how genetic risk is linked to regional vulnerability across tau dementias.

Bacteria use diverse immune systems to defend against viral infection. Here, Hooper et al. show that the Hna system is an ATP-regulated DNA nuclease activated by phage proteins. They further reveal how viruses can both trigger and evade this bacterial immune response.

STING agonism can promote antitumor immunity, however, mechanisms of resistance to STING activation have been described in several cancer types. Here the authors report that upregulation of PTPN2 in head and neck squamous cell carcinoma is associated with STING suppression, showing that PTPN2 inhibition restores tumor cell STING expression, and enhances response to STING agonism and antitumor immunity.

TBC1D19 and KIAA1841 are subunits of the tubulin poly-glutamylase complex and essential for assembly of an active holo-enzyme. TBC1D19 also promotes assembly/stability of primary cilia and phosphoinositide homeostasis.

Comprehensive, multinational validation of the PREVENT and SCORE2 cardiovascular risk scores, used in the United States and Europe, respectively, in 44 observational studies and 18 randomized trials, shows similar performance for the two risk scores and generally good performance across geographical regions.

Retroelement transcripts-derived double-stranded RNAs (dsRNAs) can trigger innate immune responses in cancer through a process known as viral mimicry. Here the authors show that METTL3, the writer of m6A modification, regulates the abundance of steady-state dsRNAs and it could be targeted together with DNA methyltransferases to enhance viral mimicry in colorectal cancer therapy.

Observation-constrained climate models indicate that canopy temperatures will warm more than air temperatures by 2100, leading to underestimation of vegetation thermal stress when using air temperature alone, particularly in regions with increasing atmospheric dryness.

The MAYA trial utilized temozolomide in microsatellite stable (MSS) colorectal cancers (CRC) sensitizing them to immune checkpoint inhibition. Here, the integration of spatial, transcriptomic, and immune profiling of longitudinal tumor and blood samples identify molecular determinants of therapeutic response in MSS-CRC.

The success of KRAS G12C mutation specific inhibitors in patients with KRAS-driven tumours is limited by the emergence of acquired resistance. Here, the authors characterise olomorasib, a next-generation covalent KRAS G12C-mutant inhibitor, demonstrating efficacy in the presence of clinically relevant resistance mutations in preclinical KRAS-driven cancer models.

Allogeneic CAR T cells carry a higher risk of immune rejection, which may limit persistence and therapeutic efficacy. The authors here show that co-expression of an anti-rejection CD70 CAR with a CD19 CAR enhances persistence and activity in preclinical models of cancer and autoimmune disease.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

The role of lumen acidification during endosome maturation has been unclear. Here, the authors show that proton efflux via a Na+/H+ exchanger is detected by a pH-sensitive Rab GAP, which promotes endosome maturation, supporting inside-out proton signaling and linking efflux to neural diseases.

PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

Compound-mediated targeted protein degradation through the recruitment of Ub ligases is an emerging field. Here, the authors determine key structural and biochemical principles for harnessing SCF-FBXO22, allowing for the discovery of improved degraders for the neosubstrate and oncogenic target NSD2.

Although river protection is core to social and environmental well-being, the extent to which river conservation policies are effective is difficult to assess. This study reveals that, under all relevant protection mechanisms in the contiguous USA, only 12% of rivers are adequately protected.

In vivo recordings of hypothalamic CRH neuron activity in mice reveal changes in pup cue evoked responses but minimal changes in threat-evoked neural activity during lactation.

The phenotypic and functional heterogeneity of Natural Killer (NK) cells between immunologically distinct tumor types has not been extensively investigated. Here, the authors combine multi-omic approaches, analysis of patient cohorts, and preclinical mouse models, comparing HGSOC to NSCLC as putative checkpoint-resistant and sensitive tumours. They observe an enrichment in NKG2A⁺ NK cells in HGSOC and propose that its inhibition boosts NK cell-CD8⁺ T cell interactions for improved cancer immunotherapy.

Genetic variants can lead to variable outcomes in neurodevelopmental disorders. Here, the authors show that the 16p12.1 deletion and genetic background jointly shape chromatin regulation and neurodevelopmental phenotypes, explaining variable disease expressivity.