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Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Synovial sarcoma (SS) is a difficult-to-treat cancer, driven by the fusion oncoprotein SS18::SSX. SS18::SSX alters the BAF (mammalian SWI/SNF) chromatin remodelling complex to create an oncogenic transcriptome. Here, the authors identify SS18::SSX-driven SMARCE1 SUMOylation as a therapeutic vulnerability in SS and show that SUMOylation inhibition stabilizes the cBAF complex, inducing cell death and sensitization of SS to chemotherapy.

Glassy MOF membranes fabricated via a liquid-metal interface enable defect-mediated CO₂ transport, revealing how interfacial control and defect engineering combine to produce high-performance porous membranes.

Encasing a single atom within a fullerene (C₆₀) cage can create a robustly packaged single atomic spin system. Here, the authors perform electron paramagnetic resonance on a single encased spin using a diamond NV-center, demonstrating the first steps in controlling single spins in fullerene cages.

The precise characterization of magnetic fields with a bandwidth of up to 3 GHz and localized on a nanometric scale is achieved by means of the coherent control of single electron and nuclear spins.

[1.1.1]Propellane is a highly strained smallest tricyclic hydrocarbon, and its reactivity is primarily focused on addition reactions across the strained C-C bond, leading to the formation of bicyclo[1.1.1]pentane derivatives. Herein, the authors present a [2,3]-sigmatropic rearrangement that uses [1.1.1]propellane as a carbene precursor to rapidly access allenylated or allylated methylenecyclobutanes.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Fiber-optics based on organic crystals could have potential for unique telecommunications applications but typically transmit visible wavelengths. Here the authors present mechanically robust organic crystals with favourable optical properties across the main telecommunication bands in the near-infrared.

This Review article provides an update on the pathophysiology, diagnosis and treatment of Takayasu arteritis. The authors emphasize the need for a multidisciplinary approach to the diagnosis and management of this complex disease.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Molecular crystals can be bent elastically by expansion or contraction on opposite faces, or plastically by delamination into slabs that glide along slip planes. Here the authors report crystals that can be bent plastically while undergoing a mechanically induced phase transition without delamination.

Engineering 2D heterostructures with unique physiochemical properties and molecular sieving channels is one approach for designing membranes selective gas molecule transport. Here authors arrange graphene and boron nitride nanosheets in an alternating pattern, resulting in narrow porous nanochannels and excellent hydrogen separation properties.

Self-healing in structurally ordered materials is restricted by slow interfacial mass transport and the need for ideal physical alignment. Here the authors show self-healing in an anilinium bromide crystals achieving up to 95% recovery through ferroelastic detwinning.

Some bacteria can feed on live fungi through unclear mechanisms. Here, the authors show that a T3SS-secreted protein, which is homologous to phage tail proteins, allows a Burkholderia gladioli strain to kill and feed on various fungal species.

Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.

Organic electronics requires dynamic materials, however, most of them have small strokes and operate at high temperatures. Here, the authors describe organic crystal that repeatedly expands and contracts nearly half its length around room temperature.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Zhang et al. report that in response to ROS, ATM regulates peroxisome homeostasis through the phosphorylation of PEX5, which is then ubiquitylated and can be recognized by p62 to specifically activate pexophagy.

The existing paradigms of system-bath control typically assume that the bath state is unchanged. By using spin defects in diamond, Dasari et al. demonstrate a scheme for controlling the state of the nuclear spin bath via selective measurements of the central qubit as a way of extending the qubit coherence time.

High sensitivity in quantum sensing comes often at the expense of other figures of merit, usually resulting in distortion. Here, the authors propose a protocol with good sensitivity, readout linearity and high frequency resolution, and benchmark it through signal measurements at audio bands with NV centers.

The performance of membrane desalination of seawater is hampered by fouling. Here the authors develop smart gating hybrid membranes by surface coating with polymer-embedded thermosalient crystals. These membranes enhance pure water flux by over 40% in saltwater desalination by osmotic distillation.

High-resolution microwave detection with NV centers in diamond is currently applicable to signals with frequencies below 10 MHz, thus limiting their range of applications. Here, the authors demonstrate detection of GHz signals with sub-Hz spectral resolution, not limited by the quantum sensor lifetime.

Lillianite materials usually have low thermoelectric efficiency due to the inherently inferior electrical properties. Here, the authors evaluate thermoelectric performances in Pb₇Bi₄Se₁₃ based lillianites enabled by convergence of nested conduction bands.

Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.

KDM5B recruits SETDB1 to repress endogenous retroelements such as MMVL30, suppressing anti-tumour immunity, and the depletion of KDM5B induces a robust adaptive immune response and enhances the response to immune checkpoint blockade.

Defects in silicon carbide can act as single photon sources that also have the benefit of a host material that is already used in electronic devices. Here the authors demonstrate that they can control the distinguishability of the emitted photons by changing the defect spin state.

Quantum sensors can have exceptional properties but the limits on their performance involve nonclassical effects such as quantum backaction. Here the authors show how to mitigate the effects of backaction on the spectral resolution of an NV centre nuclear spin sensor by controlling the measurement strength.

Chemiluminescence is known in solution, but has remained undetected in macroscopic crystalline solids so far. Here the authors demonstrate direct transduction of heat into light by thermochemiluminescence in a centimeter-size lophine hydroperoxide crystal.

The use of ATP competitive kinase inhibitors against the pseudokinase Her3 has been largely unsuccessful. Hydrophobic tagging of a covalent kinase inhibitor promotes Her3 degradation and prevents productive dimerization and signaling.