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RNA velocity is a widely used method to predict the fate of single cells. Here the authors show that the concept can be adapted to predict the fate of individual human subjects, using RNA velocity of whole blood at a single point in time to predict future clinical outcomes and treatment responses.

Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Mediterranean ecosystems are at risk of invasive weeds. Here, the authors assess fitness-related traits in common dandelions with culling experiments, finding that plants with intact microbiomes exhibit increased competitiveness in comparison to local species.

The study identifies novel genetic variants linked to core cerebrospinal fluid Alzheimer’s Disease biomarkers using a genome-wide analysis, showing how endophenotypes can identify genes and disease mechanisms not captured by case-control studies.

Ibiza, an island in present-day Spain, was under Islamic rule between the 10^th and 13^th centuries CE. Here, the authors analyse the remains of thirteen individuals from medieval Islamic burials in Ibiza, describing their ancestries and pathogens.

Experimental evolution enables evaluation of the relative roles of chance and necessity in evolution. This study compiles transcriptomic data from experimental evolution of a prokaryotic and five eukaryotic species in 22 environments to reveal that gene expression evolution is often repeatable and deterministic.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

This study maps out the diversity and evolution of the bacterial order Caulobacterales, including the model organism C. crescentus, which reveals widespread phototrophy and illuminates the evolution of bacterial cell shapes and lifecycle complexity.

An improved strategy for siting food and energy production is needed to avoid further habitat loss. This paper presents a multi-sector framework that can empower land use planners to find synergies across conservation and development sectors.

In the phase 3 EMN24 IsKia trial, transplant-eligible patients with newly diagnosed multiple myeloma who received isatuximab with carfilzomib, lenalidomide and dexamethasone pretransplant induction and post-transplant consolidation showed higher rates of measurable residual disease negativity after consolidation than patients who received carfilzomib, lenalidomide and dexamethasone.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Laser-driven neutron sources offer unique advantages for fundamental physics and applications. Here, authors present an experiment at the DRACO PW laser where they achieved for the first time single neutron detection of fast neutrons, establishing LDNSs as a promising, scalable platform for future fast neutron-induced reaction studies.

This case study reports human immunodeficiency virus remission without antiretroviral treatment in an individual who received an allogeneic haematopoietic stem cell transplantation from a sibling donor with a homozygous CCR5Δ32 mutation.

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

The spread of non-native species is likely to be compounded by further climate change and land-use intensification. Here the authors assess the potential distribution of 9,701 naturalized non-native plant species at a 10 × 10-km grid resolution and project shifts under two Shared Socioeconomic Pathways.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

Ecuador’s reliance on hydropower led to an energy crisis following two failed rainy seasons, highlighting the need for alternative solutions. Here the authors demonstrate that integrating solar and wind power with hydropower, leveraging ’extreme-year synergy’, can stabilize energy supply during droughts, offering a model for increased power system resilience in hydro-dependent regions globally.

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in association with epigenetic remodeling in the intestine

Ruminal microbial genes and cattle (Bos taurus) genetics predict about 60% of enteric methane emission variation between animals, supporting strategies aimed at reducing these emissions.

Analyzing data of the Mexican Biobank project, a new study finds regional differences in clinically relevant genetic frequencies and presents MexVar, a publicly accessible resource designed to support ancestry-informed genetic testing.

In this Journal Club, Rodríguez-Lelis and Gómez-Schiavon discuss a study that challenges the oncogene-induced senescence paradigm and proposes that cooperative, feedback-driven growth arrest better explains growth dynamics in BRAF-mutant benign nevi.

In vitro functional assays link alternative MC1R alleles to least weasels’ camouflage in environments with different winter snow, and population genomics sheds light on their evolutionary origin and balanced maintenance across heterogeneous habitats.

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

Drought conditions in soil systems lead to elevated concentrations of natural antibiotics, as well as the enrichment of antibiotic-resistant microorganisms, highlighting a link between climate and the spread of antimicrobial resistance.

METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors identify a noncoding regulatory region at the Fgf9 locus and reveal that Meis genes are key regulators of sexual differentiation.

Bacterial ribonucleoprotein bodies are dynamic biomolecular condensates that play roles in RNA metabolism. Here, Ortiz-Rodríguez et al. show that, under stress, these condensates shift from a liquid state to a rigid state and switch their function from mRNA decay to mRNA storage, thus enabling transcript preservation and rapid recovery upon nutrient replenishment.

Non-additive effect and trait-trait interactions are often overlooked in current genomic prediction approaches. Here, the authors extend quadratic phenotypic selection index to the genomic domain to enable phenotype-free, rapid-cycle multi-trait selection while capturing genome-wide nonlinear relationships.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Proximity-dependent biotinylation coupled with ubiquitin remnant enrichment identifies PROTAC-induced ubiquitylation sites and E3 ligase substrates.

Large benthic oxygen isotope fluctuations in the Oligocene Southern Ocean primarily represent deep water temperature changes, suggesting the Antarctic ice sheet volume was relatively stable, according to a clumped isotope record.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Alcohols are one of the most abundant functional groups in commercially available materials and biologically active compounds. Here, the authors report a metal-free photocatalytic method for the deoxygenative Z-selective olefination of aliphatic alcohols.

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples from diverse ancestries in cancer genomics studies.

The most parsimonious network of routes taken by the first people navigating Sahul emerge from landscape-based rules, which can also be applied to other peopling events, to quantify the likely patterns of the peopling of Earth.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Self-propelled jumping of droplets becomes more challenging as droplet size increases. In this study, the authors report passive jumping of a water puddle at an unprecedented centimeter scale from a superhydrophobic surface, triggered by the burst of an entrained bubble.

Polygenic scores often underperform in non‑European ancestries. Here, the authors present GPTL, an R package with three transfer‑learning methods that improve cross‑ancestry PGS using either individual‑level data or GWAS summary statistics.

Hole spin qubits in germanium are well suited for fast, electrically driven gates with high fidelity, but scaling to large qubit arrays remains challenging. Here the authors demonstrate a 10-spin qubit array with gate fidelities exceeding 99%, revealing mechanisms for uniform and scalable qubit control.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.