Electron tomography and RNA interference have been used to define a structural and molecular pathway for centriole assembly in C. elegans. Centriole assembly occurs in at least three distinct steps: tube formation, tube elongation and singlet microtubule assembly. These results should have general relevance for further studies on centriole assembly in other organisms.
- Laurence Pelletier
- Eileen O’Toole
- Thomas Müller-Reichert
