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Showing 1–22 of 22 results
Advanced filters: Author: Francis Berenbaum Clear advanced filters

  • The COVID-19 pandemic has put pressure on researchers around the world. In this Viewpoint, six rheumatology researchers at different career stages and from different regions discuss the difficulty of conducting research during the pandemic, and also reflect on how the pandemic has changed their attitudes towards research and their plans for the future.

    • Paula Alba Moreyra
    • Francis Berenbaum
    • Sowmya Viswanathan
    Reviews
    Nature Reviews Rheumatology
    Volume: 18, P: 128-132

  • Despite the increasingly recognized impact of hand osteoarthritis, clinical trials of therapeutics for this disease are lacking. In this context, the authors of this Viewpoint article highlight the limitations of current outcome measures for hand osteoarthritis, and argue that improvements to these measures are needed, as well as the development of new tools.

    • Emmanuel Maheu
    • Francis Berenbaum
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 136-138

  • Moving beyond the view of osteoarthritis as a disease of the cartilage, evidence is emerging that synovial inflammation is an important factor in the pathophysiology of the disease. In this article, Sellam and Berenbaum review that evidence, present various methods of assessing synovitis, and discuss the possibility of synovitis-targeted therapy for the treatment of osteoarthritis.

    • Jérémie Sellam
    • Francis Berenbaum
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 625-635

  • IL-6 blockade represents a promising therapeutic approach for the treatment of osteoarthritis (OA), although durable effects have yet to be explored in clinical trials. Here, the authors report the results of a phase I randomized clinical trial testing the efficacy and safety of PPV-06, an anti-IL-6 active immunotherapy able to modulate the activity of circulating IL-6 in patients with knee OA.

    • François Rannou
    • Lucille Desallais
    • Jean-François Zagury
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • In the past two decades the field of hand osteoarthritis (OA) has moved from resignation to action. Despite progress, such as the recognition of the phenotypic heterogeneity of hand OA (including inflammation- and/or metabolic syndrome-associated hand OA) and the standardization of imaging and treatment outcomes, challenges remain in achieving truly disease-modifying therapies.

    • Francis Berenbaum
    • Emmanuel Maheu
    Comments & Opinion
    Nature Reviews Rheumatology
    Volume: 21, P: 646-647

  • With the advent of the internet and advances in social media and mobile devices, how people access information is rapidly evolving. In this Perspectives, Francis Berenbaum discusses the emerging uses of social media in medicine, with insights as to how social media is used in rheumatology in particular and how these developments are changing the way in which clinicians and patients interact.

    • Francis Berenbaum
    Comments & Opinion
    Nature Reviews Rheumatology
    Volume: 10, P: 314-318

  • Tendon disorders are common and are a major cause of musculoskeletal pain, but the development of effective therapies requires detailed knowledge of the biology of this mechanosensitive musculoskeletal tissue. As well as providing an overview of tendon physiology and pathology, this article reviews the mechanical and biological factors that contribute to tendon development, homeostasis and repair, drawing on evidence from experimental models and developmental biology.

    • Geoffroy Nourissat
    • Francis Berenbaum
    • Delphine Duprez
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 223-233

  • This Perspective article discusses the stratification of patients with knee osteoarthritis (OA) in the context of current guidelines, biomarkers and emerging and future developments of targeted treatment. The authors aim to highlight how these novel developments can enhance the stratification of patients with knee OA to improve patient outcomes.

    • Nicholas R. Fuggle
    • Roland Chapurlat
    • Nicholas C. Harvey
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 684-695

  • Emerging evidence suggests the nervous system, including the circadian timing system, influences susceptibility to osteoarthritis (OA) via direct and indirect effects. This Review describes the interactions between the brain and the joints in the context of OA, ageing, obesity and inflammation, and outlines therapeutic and research opportunities in this field.

    • Francis Berenbaum
    • Qing-Jun Meng
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 508-516

  • Alarmins are endogenous molecules that have host-protective roles but have also been implicated in the pathogenesis of joint diseases. This Review summarizes the roles of alarmins in osteoarthritis and inflammatory arthritis, highlighting them as novel therapeutic targets in these diseases.

    • Meriam Nefla
    • Dirk Holzinger
    • Claire Jacques
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 669-683

  • Environmental changes can sometimes be too rapid for genetic adaptation and result in a mismatch between our genetics and the environment. Osteoarthritis should be considered a mismatch disease owing to a rapid increase in prevalence that is associated with the modern lifestyle, diet and patterns of physical activity.

    • Francis Berenbaum
    • Ian J. Wallace
    • David T. Felson
    Reviews
    Nature Reviews Rheumatology
    Volume: 14, P: 674-681

  • This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in osteoarthritis and the challenges that limit the movement towards personalized medicine.

    • David Moulin
    • Jérémie Sellam
    • Marie-Astrid Boutet
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 221-236

  • In this Review, the authors explore the complex interactions between osteoarthritis-related pain and obesity, adipose tissue dysfunction and metabolic syndrome, and discuss how knowledge of these relationships could help improve pain management and identify new therapeutic options.

    • Marie Binvignat
    • Jérémie Sellam
    • David T. Felson
    Reviews
    Nature Reviews Rheumatology
    Volume: 20, P: 565-584

  • Hypertension and osteoarthritis are associated with each other epidemiologically and share several molecular pathways. In this Review, the authors examine the crossover between these two conditions and propose the repurposing of antihypertensive medications to treat osteoarthritis.

    • Karen Ching
    • Xavier Houard
    • Chunyi Wen
    Reviews
    Nature Reviews Rheumatology
    Volume: 17, P: 533-549