Search

Metal–support interfaces play a crucial role in dictating the catalytic behavior of heterogeneous systems. Here, the authors reveal a unique looping metal–support interaction in NiFe–Fe₃O₄ catalysts, where spatially separated yet coupled redox cycles boost hydrogen oxidation, providing new insights for the design of efficient heterogeneous catalysts.

Cerebral palsy lacks reliable biomarkers for early and accurate diagnosis. Here, the authors show serum proteomic signatures of disease and develop a multi-biomarker diagnostic model.

Arctic sea ice loss is reshaping the ocean’s carbon pump. Satellite data show an early boost, then stagnation, while models warn of future weakening under ice-free conditions, threatening carbon storage and ecosystems.

Zero-field mobility has been an unreliable indicator to predict thick-film organic solar cell performance. Here, authors reveal that critical length is a decisive factor governing thick-film device performance and achieve maximum efficiency of 19.0% in 300-nm thick-film D18:L8-BO:BTP-eC9 devices.

In this study, the authors perform an interactome study of Zika virus (ZIKV) 5’UTR stem-loop B region and identify two host factors, interleukin enhancer binding factor 3 (ILF3) and DEAH-box helicase 9 (DHX9), that positively regulate antiviral RNAi to inhibit virus replication and ZIKV-induced microcephaly in vivo.

Ovarian endometriomas, with distinct microenvironment and heightened hormonal sensitivity, are recognized as precursors of ovarian carcinomas. This study decodes ovarian endometriomas by integrating single-cell and spatial transcriptomics with spatial metabolomics to reveal key markers and altered pathways, offering new avenues for diagnosis and therapy.

EMO integrates DNA sequence and chromatin accessibility data to predict how noncoding variants regulate gene expression across tissues and single cells, enabling context-aware personalized insights into genetic effects for precision medicine.

Entanglement is not the only type of quantum correlation. Quantum discord is a broader measure of such non-classical interactions. An experimental investigation now shows how quantum discord can be consumed to encode information, even in the absence of entanglement.

Boron neutron capture therapy (BNCT) is a type of radiotherapy that induces cell damage through a localized nuclear reaction. Here the authors describe the design of a carborane-based covalent organic framework as a boron capsule loaded with immune adjuvants for concurrent BNCT and immunotherapy, promoting anti-tumour immune responses in preclinical cancer models.

Liver proteome dysregulation contributes to the development of alcohol-associated liver disease (ALD), a major global health challenge. Here, the authors develop an approach to specifically identify the liver nascent proteome under various physiological and pathological conditions, revealing key regulators involved in hepatic steatosis.

Implementing metal nanowires in photonic circuits is challenging due to lack of suitable manipulation techniques. Here, the authors present an earthworm-like peristaltic crawling motion mechanism, based on surface plasmons and surface acoustic waves, and show on-chip manipulations of single nanowires.

This study reveals that wheat migration as a strategy for climate adaptation lacks sustainability in the North China Plain. Irrigation and fertilization management provide mitigation opportunities to reduce negative environmental impacts and avoid carbon leakage.

Two-dimensional magnetic semiconductors hold promise for spin- and valleytronic applications. Here, the authors report the realization of light helicity detectors based on graphene/CrI₃ van der Waals heterostructures, exhibiting a photocurrent behaviour determined by the magnetic state of CrI₃.

Van der Waals magnetic materials are characterized by strong magnetic interactions within each van der Waals layer, while the interaction between the layers is typically weaker. Here, Liu, Su, Gu and coauthors find a magnetic phase transition in the van der Waals magnet, NiI₂, under hydrostatic pressure, which they associate with the interlayer magnetic interaction.

This study reveals a shallow asthenosphere with high ³He/⁴He ratios (>20 R_A) beneath Patagonia. This primordial composition is linked to the Karoo mantle plume from the early stages of the Gondwana breakup.

The stereospecific Z/E isomerization of tetrasubstituted alkenes remains underdeveloped, thus lacking in a stereodivergent synthesis of axially chiral alkenes. Here, authors report the atroposelective synthesis of tetrasubstituted alkene analogues by asymmetric allylic substitution-isomerization, followed by the photocatalyzed Z/E isomerization.

UTe₂ is a proposed intrinsic topological superconductor, but its quasiparticle surface band has not yet been visualized. Now this is achieved using quasiparticle interference imaging, revealing the symmetry of the superconducting order parameter.

Triggering and sustaining fusion reactions — with the goal of overall energy production — in a tokamak plasma requires efficient heating. Radio-frequency heating of a three-ion plasma is now experimentally shown to be a potentially viable technique.

The acetylene hydrogenation activity and stability of a palladium single-atom catalyst are both controlled by the lowest unoccupied molecular orbital of the oxide support.

Generation of water as a byproduct in chemical reactions is often detrimental because it lowers the yield of the target product. Here, a thermally rearranged polybenzoxazole membrane has been developed, allowing for selective removal of water in chemical reactions.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Montoliu-Gaya, Salvadó et al. develop a blood-based model using tau biomarkers measured in a single analysis enabling biological staging of Alzheimer’s disease to support the diagnosis, prognosis and identification of patients likely to benefit from targeted therapies.

A 10-Earth-mass planet is detected in the habitable zone of the solar-type star Kepler-725 using the transit timing variation technique. This study proposes a complementary pathway to probe low-mass exoplanets (including Earth-like planets) in the habitable zones of Sun-like stars.

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.

Proteome allocation to anabolic and catabolic functions is significantly regulated by growth rate in the model bacterium Escherichia coli. By contrast, this article shows that proteome allocation is only partially controlled by growth rate, and metabolic rates are primarily controlled post-translationally, in the thermophilic acetogen Thermoanaerobacter kivui.

Subduction-driven warming and uplift are linked to the Cambrian Explosion, and Li-Os-Sr isotopes trace enhanced erosion of phosphorus-rich juvenile rocks that boosted productivity and oxygen levels to fuel animal diversification.

SRD5A2 has clinical relevance in benign prostatic hyperplasia, prostate cancer and other androgen-mediated conditions. In this Review, the authors describe the complementary roles of α-blockers for rapid symptom relief and 5α-reductase inhibitors for disease modification and progression risk reduction in benign prostatic hyperplasia and the potential of targeting SRD5A2 in other androgen-driven disorders.

There is great interest in methods for catalytic enantioselective construction of axially chiral compounds found in natural products. Here, the authors develop a cycloaddition strategy for atroposelective construction of indole-based biaryls via chiral phosphoric acid-catalysed cycloaddition.

This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial perception in mice.

Blood cancers generally derive from the bone marrow but there are no current targeted treatments. Here the authors present a bone-marrow-targeting nanoparticle that can bind and pull together tumour and natural killer cells for selective elimination of cancer cells, offering a strategy for the treatment of haematologic cancers.

When a topological insulator is coupled with a superconductor, supercurrents arise that—if fully understood—may allow the detection of long-sought Majorana fermions. Here the nature of these supercurrents is further elucidated as they are characterized as non-symmetric and carried by surface states.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Long-lived room temperature phosphorescence (LRTP) is important in organic photonics but exploring a universal approach to obtain LRTP in amorphous polymers is challenging. Here the authors present a facile chemical strategy to achieve ultralong phosphorescence in polymers by ionic bonding cross-linking.

Here, the authors characterize a newborn-derived monoclonal IgM, showing it influences bacterial clustering, gene expression, and metabolic activity, thereby modulating gut bacterial functions and host metabolism without altering microbiota composition.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

Transition metal carbides exhibit outstanding performance in the selective hydrogenation of acetylene, but carburizing Pd-based intermetallic compounds has been challenging. Here, the authors present a successful synthesis of Pd₃ZnC_x intermetallic carbide for selective hydrogenation of acetylene through a one-step co-infiltration of zinc and carbon using syngas.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Metallocene-based phosphines are compounds with potential use in catalysis. Here, the authors report the electrochemical regioselective functionalization of group 8 metallocenes with phosphine oxides; over 60 examples of phosphorylated (benzo)ferrocenes and ruthenocenes can be accessed via this method without the need for a preinstalled directing group.

In this work the authors uncover a transient non-Hermitian skin effect. Using a passive system, they confirm the exact evolution of NHSE by leveraging the complex-frequency excitation. This demonstration can be extended to other non-Hermitian phenomena in various passive systems.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.