Nature Search

Targeting metastatic bladder cancer when money is an issue

The treatment landscape for advanced urothelial carcinoma has drastically improved, yet global access to novel agents remains unequal. Thus, answering crucial clinical questions regarding platinum-backbone optimization, chemotherapy and treatment duration, and metastasis-directed therapies is essential to maximize outcomes with currently available, widespread standards of care.

Jorge Esteban-Villarrubia
Guillermo de Velasco
Comments & Opinion13 Apr 2026
Nature Reviews Urology

P: 1-2
Preliminary ultrastructural analysis suggests phenotype-specific myofiber alterations in idiopathic inflammatory myopathies

Andrea Aguilar-Vazquez
Christian Juarez-Gomez
Monica Vazquez-Del Mercado
ResearchOpen Access06 Mar 2026
Scientific Reports

Volume: 16, P: 1-18
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Correction: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Valentina Cianfanelli
Claudia Fuoco
Francesco Cecconi
Amendments and Corrections30 Apr 2015
Nature Cell Biology

Volume: 17, P: 706
Targeted genomic landscape of metastases compared to primary tumours in clear cell metastatic renal cell carcinoma

Guillermo de Velasco
Stephanie A. Wankowicz
Toni K. Choueiri
ResearchOpen Access20 Apr 2018
British Journal of Cancer

Volume: 118, P: 1238-1242
Towards the use of cannabinoids as antitumour agents

Cannabinoids have well-established roles in palliating cancer-associated symptoms, but numerous recent studies also support their antitumorigenic activity. This Opinion article focuses on preclinical studies of the antitumour effects of cannabinoids, including the associated cellular signalling pathways and resistance mechanisms.

Guillermo Velasco
Cristina Sánchez
Manuel Guzmán
Reviews04 May 2012
Nature Reviews Cancer

Volume: 12, P: 436-444
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

Xose S. Puente
Magda Pinyol
Elías Campo
ResearchOpen Access05 Jun 2011
Nature

Volume: 475, P: 101-105
Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

A study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistance to immune checkpoint inhibition in cancer.

Ignacio Melero
Maria de Miguel Luken
Eugen Leo
ResearchOpen Access11 Dec 2024
Nature

Volume: 637, P: 1218-1227
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

Ignacio Melero
Maria de Miguel Luken
Eugen Leo
Amendments and CorrectionsOpen Access25 Feb 2025
Nature

Volume: 639, P: E18
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Malumbres and colleagues reveal that mitotic arrest is accompanied by reduced mitochondrial mass and oxidative respiration resulting in activation of AMPK and induction of glycolysis to promote cell survival.

Elena Doménech
Carolina Maestre
Marcos Malumbres
Research31 Aug 2015
Nature Cell Biology

Volume: 17, P: 1304-1316
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

AMBRA1-mediated degradation of cyclin D through CRL4–DDB1 regulates cell proliferation and prevents replication stress in neurodevelopment and cancer.

Emiliano Maiani
Giacomo Milletti
Francesco Cecconi
Research14 Apr 2021
Nature

Volume: 592, P: 799-803
Patients’ and professionals’ perspective of non-in-person visits in hereditary cancer: predictors and impact of the COVID-19 pandemic

Adrià López-Fernández
Guillermo Villacampa
Judith Balmaña
Research06 Apr 2021
Genetics in Medicine

Volume: 23, P: 1450-1457
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

mTOR signalling both inhibits autophagy and promotes cell proliferation. Cecconi and colleagues report that AMBRA1 links these two processes by facilitating dephosphorylation and degradation of the proto-oncogene c-Myc.

Valentina Cianfanelli
Claudia Fuoco
Francesco Cecconi
Research01 Dec 2014
Nature Cell Biology

Volume: 17, P: 20-30
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Torrano et al. use bioinformatics analyses to identify PGC1α as a transcriptional regulator of a metabolic program downstream of ERRα that opposes metastatic dissemination in prostate cancer.

Veronica Torrano
Lorea Valcarcel-Jimenez
Arkaitz Carracedo
Research23 May 2016
Nature Cell Biology

Volume: 18, P: 645-656
Urothelial cancer proteomics provides both prognostic and functional information

Guillermo de Velasco
Lucia Trilla-Fuertes
Daniel Castellano
ResearchOpen Access17 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019

Fenofibrate has been shown to inhibit SARS-CoV-2 replication in vitro. Results from a randomized clinical trial show that treating patients with COVID-19 with fenofibrate has no significant effect on clinically relevant outcomes.

Julio A. Chirinos
Patricio Lopez-Jaramillo
Pedro Antonio Segura-Saldaña
Research07 Nov 2022
Nature Metabolism

Volume: 4, P: 1847-1857
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

Inhibition of histone and DNA methyltransferase activity enhances sensitivity to platinum-based and immunotherapy in a novel transgenic mouse model of metastatic bladder cancer.

Cristina Segovia
Edurne San José-Enériz
Jesús M. Paramio
Research03 Jul 2019
Nature Medicine

Volume: 25, P: 1073-1081
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality.

Luis A. Pérez-Jurado
Alejandro Cáceres
Juan R. González
ResearchOpen Access19 Feb 2024
Communications Biology

Volume: 7, P: 1-14
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Carlos López-Otín, Elías Campo and colleagues report exome sequencing of tumor and normal samples from 105 individuals with chronic lymphocytic leukemia (CLL). They identify 1,246 somatic mutations predicted to affect gene function and 78 genes with recurrent predicted functional mutations. They find recurrent mutations in the gene encoding the SF3B1 splicing factor, which was mutated in 10% of the CLL samples.

Víctor Quesada
Laura Conde
Carlos López-Otín
Research11 Dec 2011
Nature Genetics

Volume: 44, P: 47-52
A prognostic microRNA-based signature for localized clear cell renal cell carcinoma: the Bio-miR study

Álvaro Pinto-Marín
Lucía Trilla-Fuertes
Angelo Gámez-Pozo
Research07 May 2025
British Journal of Cancer

Volume: 133, P: 155-167
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Quality of life and clinical data in hemodialysis patients with different degrees of pruritus

Sebastián Mas Fontao
Paula Manso
María Melissa Vasquez
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients

Alfonso Alba-Bernal
Ana Godoy-Ortiz
Emilio Alba
ResearchOpen Access15 May 2024
npj Breast Cancer

Volume: 10, P: 1-14
Prevalence of pathogenic germline variants in patients with metastatic renal cell carcinoma

María Santos
Javier Lanillos
Cristina Rodriguez-Antona
Research13 Jan 2021
Genetics in Medicine

Volume: 23, P: 698-704
Curcumin reduces enteric isoprostane 8-iso-PGF2α and prostaglandin GF2α in specific pathogen-free Leghorn chickens challenged with Eimeria maxima

Victor M. Petrone-Garcia
Raquel Lopez-Arellano
Guillermo Tellez-Isaias
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome

Juan María Roldan-Romero
María Santos
Cristina Rodriguez-Antona
Research02 Jul 2020
Modern Pathology

Volume: 33, P: 2580-2590
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15
Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

Hongtao Guan
Aban Shuaib
Endre Kiss-Toth
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4

Amanda Burnett
Ingrid Gomez
Victoria Ridger
ResearchOpen Access24 May 2017
Scientific Reports

Volume: 7, P: 1-9
Less frequent complications following CAR T-cell therapies: hemophagocytic lymphohistiocytosis, graft-versus-host disease, thrombotic microangiopathy, coagulation disorders and secondary malignancies: best practice recommendations from the EBMT Practice Harmonization and Guidelines Committee

Guillermo Ortí
Guillaume Dachy
Olaf Penack
Reviews09 Apr 2025
Bone Marrow Transplantation

Volume: 60, P: 751-758
Robust estimation of bacterial cell count from optical density

In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

Jacob Beal
Natalie G. Farny
Jiajie Zhou
ResearchOpen Access17 Sept 2020
Communications Biology

Volume: 3, P: 1-29
Author Correction: Robust estimation of bacterial cell count from optical density

Jacob Beal
Natalie G. Farny
Jiajie Zhou
Amendments and CorrectionsOpen Access27 Oct 2020
Communications Biology

Volume: 3, P: 1

Search

Targeting metastatic bladder cancer when money is an issue

Preliminary ultrastructural analysis suggests phenotype-specific myofiber alterations in idiopathic inflammatory myopathies

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

Correction: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Targeted genomic landscape of metastases compared to primary tumours in clear cell metastatic renal cell carcinoma

Towards the use of cannabinoids as antitumour agents

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Patients’ and professionals’ perspective of non-in-person visits in hereditary cancer: predictors and impact of the COVID-19 pandemic

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Urothelial cancer proteomics provides both prognostic and functional information

A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019

Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

A prognostic microRNA-based signature for localized clear cell renal cell carcinoma: the Bio-miR study

Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

Quality of life and clinical data in hemodialysis patients with different degrees of pruritus

Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients

Prevalence of pathogenic germline variants in patients with metastatic renal cell carcinoma

Curcumin reduces enteric isoprostane 8-iso-PGF2α and prostaglandin GF2α in specific pathogen-free Leghorn chickens challenged with Eimeria maxima

Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome

Deciphering the impact of genomic variation on function

Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4

Less frequent complications following CAR T-cell therapies: hemophagocytic lymphohistiocytosis, graft-versus-host disease, thrombotic microangiopathy, coagulation disorders and secondary malignancies: best practice recommendations from the EBMT Practice Harmonization and Guidelines Committee

Robust estimation of bacterial cell count from optical density

Author Correction: Robust estimation of bacterial cell count from optical density

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