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Oncolytic virus VG161 in refractory hepatocellular carcinoma

Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.

Yinan Shen
Xueli Bai
Tingbo Liang
Research19 Mar 2025
Nature

Volume: 641, P: 503-511
Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma

Yinan Shen
Xueli Bai
Tingbo Liang
Amendments and Corrections23 Apr 2025
Nature

Volume: 641, P: E5
The anterior-posterior gradient of the fusiform gyrus modulates the transition between mnemonic and perceptual features during reminiscences

Here, the authors use intracranial electrical stimulation to reveal an anterior to posterior gradient in the fusiform gyrus from internal mnemonic to external perceptual experiences.

Motong Yuan
Yanyan Li
Liang Wang
ResearchOpen Access13 Aug 2025
Nature Communications

Volume: 16, P: 1-16
First-line tislelizumab and ociperlimab combined with gemcitabine and cisplatin in advanced biliary tract cancer (ZSAB-TOP): a multicenter, single-arm, phase 2 study

Guoming Shi
Xiaoyong Huang
Jia Fan
ResearchOpen Access21 Aug 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-9
The concomitant anxiety and depression in patients with epilepsy caused by low-grade brain tumors

Sungel Xie
Jiao Qiao
Shunwu Xiao
ResearchOpen Access09 Jan 2025
Scientific Reports

Volume: 15, P: 1-7
Identification and immune characteristics of N6-methyladenosine related ferroptosis-related genes in intervertebral disc degeneration

Zhen Che
Ruibing Chen
Qun Zhao
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-15
Association between the triglyceride-glucose index and calcified aortic stenosis in elderly patients: a cross-sectional study

Zhihui Hu
Tiantian Xiong
Guoming Li
ResearchOpen Access11 Sept 2023
Scientific Reports

Volume: 13, P: 1-8
Macro CD5L⁺ deteriorates CD8⁺T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response.

Jia-Cheng Lu
Lei-Lei Wu
Jia Fan
ResearchOpen Access20 Jan 2024
Nature Communications

Volume: 15, P: 1-23
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

The significance of autophagy for signal transduction has been unclear. Autophagy negatively regulates Wnt signalling by promoting Dishevelled (Dvl) degradation. The von Hippel-Lindau protein ubiquitylates Dvl to faciliatate its recruitment to autophagosomes through p62.

Chan Gao
Weipeng Cao
Ye-Guang Chen
Research18 Jul 2010
Nature Cell Biology

Volume: 12, P: 781-790
Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma

Zhuangyao Liao
Ming Li
Lin Huang
ResearchOpen Access29 Jun 2023
npj Precision Oncology

Volume: 7, P: 1-15
Coordinated NREM sleep oscillations among hippocampal subfields modulate synaptic plasticity in humans

Different subfields of the hippocampus complement and regulate each other, collectively facilitating information processing and synaptic plasticity during NREM sleep.

Zhipeng Li
Jing Wang
Xia Liang
ResearchOpen Access01 Oct 2024
Communications Biology

Volume: 7, P: 1-12
Optimization of structural reinforcement assessment for architectural heritage digital twins based on LiDAR and multi-source remote sensing

Yanru Shi
Ming Guo
Youshan Zhao
ResearchOpen Access23 Aug 2024
Heritage Science

Volume: 12, P: 1-19
Soil microbial carbon utilization, enzyme activities and nutrient availability responses to Bidens pilosa and a non-invasive congener under different irradiances

Hui Wei
Wenbin Yan
Kaiming Liang
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Comparative analysis of DNA methylome and transcriptome of skeletal muscle in lean-, obese-, and mini-type pigs

Yalan Yang
Guoming Liang
Kui Li
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-14

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Oncolytic virus VG161 in refractory hepatocellular carcinoma

Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma

The anterior-posterior gradient of the fusiform gyrus modulates the transition between mnemonic and perceptual features during reminiscences

First-line tislelizumab and ociperlimab combined with gemcitabine and cisplatin in advanced biliary tract cancer (ZSAB-TOP): a multicenter, single-arm, phase 2 study

The concomitant anxiety and depression in patients with epilepsy caused by low-grade brain tumors

Identification and immune characteristics of N6-methyladenosine related ferroptosis-related genes in intervertebral disc degeneration

Association between the triglyceride-glucose index and calcified aortic stenosis in elderly patients: a cross-sectional study

Macro CD5L⁺ deteriorates CD8⁺T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma

Coordinated NREM sleep oscillations among hippocampal subfields modulate synaptic plasticity in humans

Optimization of structural reinforcement assessment for architectural heritage digital twins based on LiDAR and multi-source remote sensing

Soil microbial carbon utilization, enzyme activities and nutrient availability responses to Bidens pilosa and a non-invasive congener under different irradiances

Comparative analysis of DNA methylome and transcriptome of skeletal muscle in lean-, obese-, and mini-type pigs

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