Nature Search

Oxygen-free metabolism in the bird inner retina supported by the pecten

While the photoreceptor outer segments in the bird outer retina have access to oxygen, the inner retina operates under chronic anoxia, supported by anaerobic glycolysis in the retinal neurons.

Christian Damsgaard
Mia Viuf Skøtt
Jens Randel Nyengaard
Research21 Jan 2026
Nature

Volume: 650, P: 657-663
Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Here the authors provide a deep tissue analysis of patients with autoimmune kidney diseases, identifying a conserved spatiotemporal immune program for the development of glomerular crescents and sclerosis.

Zeba Sultana
Robin Khatri
Christian F. Krebs
ResearchOpen Access30 Sept 2025
Nature Immunology

Volume: 26, P: 1977-1988
Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics

Medulloblastoma in children is a difficult cancer to treat and the immune response to this tumour is not fully understood. Here the authors characterise and validate T cell epitopes from these cancers using an immunopeptidomics approach, comparing different molecular subtypes.

Julia Velz
Lena K. Freudenmann
Marian C. Neidert
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-17
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

The authors demonstrate the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting that the virus is present in the CNS and may enter through the olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue.

Jenny Meinhardt
Josefine Radke
Frank L. Heppner
Research30 Nov 2020
Nature Neuroscience

Volume: 24, P: 168-175
Extreme escalation of heat failure rates in ectotherms with global warming

Within the stressful temperature range, heat failure rate increases by more than 100% per degree Celsius across a broad range of ectotherm taxa.

Lisa Bjerregaard Jørgensen
Michael Ørsted
Johannes Overgaard
Research26 Oct 2022
Nature

Volume: 611, P: 93-98
A self-organized synthetic morphogenic liposome responds with shape changes to local light cues

The authors generated a Synthetic Morphogenic Membrane System by encapsulating a dynamic microtubule aster and a light-inducible signaling system driven by GTP/ATP chemical potential into cell-sized liposomes. This reconstitution of artificial proto-cells reveals how non-equilibrium phenomena affect cellular information processing in morphogenesis.

Konstantin Gavriljuk
Bruno Scocozza
Philippe I. H. Bastiaens
ResearchOpen Access09 Mar 2021
Nature Communications

Volume: 12, P: 1-25
A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity

A phase I open-label trial evaluating the immunogencity, reactogenicity and safety of a peptide-based SARS-CoV-2 vaccine candidate to induce SARS-CoV-2-specific T cell responses.

Jonas S. Heitmann
Tatjana Bilich
Juliane S. Walz
ResearchOpen Access23 Nov 2021
Nature

Volume: 601, P: 617-622
Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma

Tumour-infiltrating lymphocytes from glioblastoma can recognize bacterial and gut microbial peptides.

Reza Naghavian
Wolfgang Faigle
Roland Martin
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 807-817
DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts

Epigenetic therapies are known to synergize with immunotherapies through the de-repression of endogenous retroviral element (ERV)-encoded promoters. Here the authors identify treatment-induced neoantigens and validate their ability to induce T cell response and anti-tumor effects in vitro and in patient samples.

Ashish Goyal
Jens Bauer
Christoph Plass
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-19
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

SARS-CoV-2-specific CD4⁺ and CD8⁺ T cell epitopes are found in both convalescent patients and virus-naive volunteers and are indicative of heterologous recognition shared with seasonal cold viruses.

Annika Nelde
Tatjana Bilich
Juliane S. Walz
Research30 Sept 2020
Nature Immunology

Volume: 22, P: 74-85
Large-scale association analyses identify host factors influencing human gut microbiome composition

Analysis of human genotypes and 16S microbiome data of 18,473 individuals from 25 cohorts through a genome-wide association study, a phenome-wide association study and Mendelian randomization identifies host genetic and microbial trait associations.

Alexander Kurilshikov
Carolina Medina-Gomez
Alexandra Zhernakova
Research18 Jan 2021
Nature Genetics

Volume: 53, P: 156-165
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Dependence of hematopoietic stem cell (HSC) fate on the phase of the cell cycle has not been demonstrated in vivo. Here, the authors find that HSCs can differentiate into a downstream progenitor without physical division, even before progressing into the S phase of the cell cycle.

Tatyana Grinenko
Anne Eugster
Ben Wielockx
ResearchOpen Access15 May 2018
Nature Communications

Volume: 9, P: 1-10
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

Lilja et al. find that SHANK proteins inhibit the signalling of Ras and Rap G-proteins by restricting their availability at the plasma membrane. This leads to restricted integrin activation, affecting cell spreading, migration and invasion.

Johanna Lilja
Thomas Zacharchenko
Johanna Ivaska
Research06 Mar 2017
Nature Cell Biology

Volume: 19, P: 292-305
Real-time observation of laser-driven electron acceleration

When a high-intensity laser pulse interacts with a plasma it generates immense fields that can accelerate charged particles. Combining high-speed polarimetry and plasma shadowgraph enables the detailed evolution of this process to be imaged in real time.

Alexander Buck
Maria Nicolai
Laszlo Veisz
Research13 Mar 2011
Nature Physics

Volume: 7, P: 543-548
Template-controlled on-surface synthesis of a lanthanide supernaphthalocyanine and its open-chain polycyanine counterpart

Extending the π‐conjugation of phthalocyanine dyes, while synthetically challenging, has the potential to produce desirable new molecular materials. Here, the authors use a templated on‐surface approach to synthesize several extended phthalocyanine derivatives from the same building block, including a lanthanide superphthalocyanine and an open‐chain polycyanine.

Qitang Fan
Jan-Niclas Luy
J. Michael Gottfried
ResearchOpen Access06 Nov 2019
Nature Communications

Volume: 10, P: 1-8
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis

GATA2 regulatory mutations are associated with hereditary congenital facial paresis in humans. A genetically engineered mouse model recapitulates the human phenotype, showing altered neuron-specific Gata2 expression and a bias in formation of inner-ear efferent neurons over facial branchial motor neurons.

Alan P. Tenney
Silvio Alessandro Di Gioia
Elizabeth C. Engle
ResearchOpen Access29 Jun 2023
Nature Genetics

Volume: 55, P: 1149-1163
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

A report of high-depth, short-read sequencing and de novo assemblies for 150 individuals from 50 parent–offspring trios as part of establishing a population reference genome for the GenomeDenmark project.

Lasse Maretty
Jacob Malte Jensen
Mikkel Heide Schierup
ResearchOpen Access26 Jul 2017
Nature

Volume: 548, P: 87-91
A single gene underlies the dynamic evolution of poplar sex determination

Populus has young sex chromosomes despite ancient dioecy. This study shows that the ARR17 gene functions as a sex switch, triggering female development when on and male development when off. This single-gene system enables dynamic evolution of poplar sex chromosomes.

Niels A. Müller
Birgit Kersten
Matthias Fladung
Research01 Jun 2020
Nature Plants

Volume: 6, P: 630-637
Ectothermy and cardiac shunts profoundly slow the equilibration of inhaled anaesthetics in a multi-compartment model

Catherine J. A. Williams
Christian Lind Malte
Tobias Wang
ResearchOpen Access13 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
Assessing the consequences of recent climate change on World Heritage sites in South Greenland

Jørgen Hollesen
Malte Skov Jepsen
Hans Harmsen
ResearchOpen Access28 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Characterization of laser-driven proton acceleration from water microdroplets

Georg A. Becker
Matthew B. Schwab
Malte C. Kaluza
ResearchOpen Access20 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock

Raphael Romano Bruno
Mara Schemmelmann
Christian Jung
ResearchOpen Access27 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective

Silke D. Werle
Nensi Ikonomi
Hans A. Kestler
ResearchOpen Access03 Jun 2023
npj Systems Biology and Applications

Volume: 9, P: 1-17
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386
Mass spectrometry-based identification of a B-cell maturation antigen-derived T-cell epitope for antigen-specific immunotherapy of multiple myeloma

Tatjana Bilich
Annika Nelde
Juliane S. Walz
ResearchOpen Access28 Feb 2020
Blood Cancer Journal

Volume: 10, P: 1-10
Discrete interactions between a few interlayer excitons trapped at a MoSe₂–WSe₂ heterointerface

Malte Kremser
Mauro Brotons-Gisbert
Jonathan J. Finley
ResearchOpen Access12 May 2020
npj 2D Materials and Applications

Volume: 4, P: 1-6
ERBB2 mutation is associated with sustained tumor cell proliferation after short-term preoperative endocrine therapy in early lobular breast cancer

Isabel Grote
Stephan Bartels
Matthias Christgen
ResearchOpen Access16 Jul 2022
Modern Pathology

Volume: 35, P: 1804-1811
A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems

Bernhard Wernly
Hans Flaatten
Christian Jung
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

Malte Buchholz
Mike Braun
Thomas M Gress
Research15 Aug 2005
Oncogene

Volume: 24, P: 6626-6636
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Dennis Das Gupta
Christoph Paul
Michael Lohoff
ResearchOpen Access22 Apr 2022
Cell Death & Differentiation

Volume: 29, P: 2163-2176
A unifying model to estimate thermal tolerance limits in ectotherms across static, dynamic and fluctuating exposures to thermal stress

Lisa Bjerregaard Jørgensen
Hans Malte
Johannes Overgaard
ResearchOpen Access18 Jun 2021
Scientific Reports

Volume: 11, P: 1-14
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis

Bernhard Wernly
Raphael Romano Bruno
Christian Jung
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
Polariton hyperspectral imaging of two-dimensional semiconductor crystals

Christian Gebhardt
Michael Förg
David Hunger
ResearchOpen Access24 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Tissue clearing may alter emission and absorption properties of common fluorophores

Farsam Eliat
Rebecca Sohn
Jan M. Bruder
ResearchOpen Access01 Apr 2022
Scientific Reports

Volume: 12, P: 1-14
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
Author Correction: Discrete interactions between a few interlayer excitons trapped at a MoSe₂–WSe₂ heterointerface

Malte Kremser
Mauro Brotons-Gisbert
Jonathan J. Finley
Amendments and CorrectionsOpen Access17 Sept 2021
npj 2D Materials and Applications

Volume: 5, P: 1-2
Stable isotopes in the atmospheric marine boundary layer water vapour over the Atlantic Ocean, 2012–2015

Marion Benetti
Hans Christian Steen-Larsen
Malte Winther
ResearchOpen Access17 Jan 2017
Scientific Data

Volume: 4, P: 1-17
Publisher Correction: Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis

Bernhard Wernly
Raphael Romano Bruno
Christian Jung
Amendments and CorrectionsOpen Access05 Jul 2021
Scientific Reports

Volume: 11, P: 1
Long-term and large-scale multispecies dataset tracking population changes of common European breeding birds

Vojtěch Brlík
Eva Šilarová
Alena Klvaňová
ResearchOpen Access26 Mar 2021
Scientific Data

Volume: 8, P: 1-9
Serotonin and Dopamine Transporter Availabilities Correlate with the Loudness Dependence of Auditory Evoked Potentials in Patients with Obsessive-Compulsive Disorder

Oliver Pogarell
Klaus Tatsch
Ulrich Hegerl
Research04 Aug 2004
Neuropsychopharmacology

Volume: 29, P: 1910-1917
Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β

Mieke Raap
Malte Gronewold
Matthias Christgen
Research16 Oct 2017
Laboratory Investigation

Volume: 98, P: 117-129
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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