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Advanced filters: Author: Hanyu Rao Clear advanced filters

SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer

SET domain–containing 2 (SETD2) is reported as an immunosuppressor in clear cell renal cell carcinoma (ccRCC). Here the authors show that SETD2 loss enhances de novo sphingomyelin biosynthesis during the transition from polycystic kidney disease to ccRCC.

Hanyu Rao
Changwei Liu
Xianting Ding
ResearchOpen Access21 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Chromosome-level genome assembly of the ratmouth barbel, Ptychidio jordani

Yuanyuan Wang
Yexin Yang
Xidong Mu
ResearchOpen Access26 Dec 2024
Scientific Data

Volume: 11, P: 1-11
NSD2 promotes cell durotaxis and drives the transition from polycystic kidney disease to tubulocystic renal cell carcinoma through integrin/FAK/AKT signaling

Wenxin Feng
Ningyuan Liu
Li Li
Research22 Jul 2025
Oncogene

Volume: 44, P: 3437-3448
Di-Ras2 promotes renal cell carcinoma formation by activating the mitogen-activated protein kinase pathway in the absence of von Hippel–Lindau protein

Hanyu Rao
Xuefeng Li
Wei-Qiang Gao
Research11 Mar 2020
Oncogene

Volume: 39, P: 3853-3866
USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells

Lin Li
Nana Liu
Huabao Liu
ResearchOpen Access05 May 2025
Scientific Reports

Volume: 15, P: 1-11