Human mitochondrial tRNAMet has a 5-formylcytidine (f5C) modification at the first anticodon position that is required for correct decoding of the AUA codon as methionine. The first step in the biosynthesis of f5C involves the S-adenosylmethionine-dependent methylation of cytidine 34 by the NSUN3 methyltransferase.
- Saori Nakano
- Takeo Suzuki
- Tsutomu Suzuki