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Chen et al. report a tailored self-assembled monolayer to create a localized 2D/3D perovskite heterojunction. This strategy reduces interfacial loss, achieving photovoltages >90% of thermodynamic limit for wide-bandgap cells, and enables perovskite-organic tandem solar cells with efficiency of 27.11%.

The molecular heterogeneity of brain metastases (BrMs) poses challenges for their treatment. Here, the authors generate a multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer BrMs and identify four molecular subtypes with distinct biological and clinical features.

Computational spectrometers are normally constrained by limited bandwidth and low light throughput of spectral encoders. Here, the authors report the realization of broadband snapshot spectrometers based on high-transparency transition metal dichalcogenides spectral encoders integrated with InGaAs photodetectors.

SARS-CoV-2 variants often exhibit immune evasion, necessitating antiviral strategies beyond vaccination. This study presents a papain-like protease (PLpro) inhibitor called YL1004, which exhibits potent, broad-spectrum antiviral activity against wild-type, Delta, and Omicron variants in vitro and in vivo.

The authors design a Pt/CuInP₂S₆/graphene heterostructure that achieves polarity-switchable photovoltaic current modulated by ferroelectric polarization. This enables programmable in-sensor computing, achieving high-performance visual tasks.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

Distributed multiparameter quantum metrology allows to probe multiple spatially distributed parameters across networked quantum systems. Here, the authors demonstrate distributed multiparameter quantum metrology in a modular superconducting quantum processor network.

E. coli is common in humans, animals and the environment but the extent of circulation between ecological niches is unclear. Here, the authors sample ~1,000 E. coli strains from different urban aquatic ecosystems in Hong Kong and describe genomic relatedness of markers of antimicrobial resistance.

A percolating interaction between antipolar regions and engineered defect pairs facilitates antipolar rotations, enabling superior energy storage performance in AgNbO₃-based ceramics.

This study elucidates a mechanism in amyloid aggregates mediated by scarce β-strands that bridge adjacent β-sheets. This cross-β-strand linker shapes molecular packing and structural diversity, enabling aggregates to balance order and disorder.

Rosiglitazone, identified through integrative network-based drug repurposing and Mendelian randomization, alleviates age-related sarcopenia in mice. It enhances muscle strength and mass, possibly through gut microbiota remodeling, activation of Igf1 signaling, and inhibition of muscle atrophy–related ubiquitin ligases.

Cities often manage food waste and wastewater separately, missing recovery synergies. Across 29 cities, urban biowaste flux identifies an ~50 kg of moisture per person per year threshold above which sewer integration lowers the net costs. Optimized city-specific strategies, including integration where beneficial, can cut emissions by up to 69% versus current separate systems.

A compression-based, regenerative elastocaloric cooling device using low-transition-temperature tubular NiTi units in a cascaded configuration, which show superelasticity and substantial entropy changes, allows the construction of a sub-zero Celsius refrigeration system without refrigerant gases.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

In this study, a series of peripheral diseases were associated with increased dementia risk and collectively were related to about one-third of the global dementia burden, indicating the value of maintaining whole-body health for brain health.

KDM7A restrains fibrotic macrophage polarization and lung fibrosis. Loss of Kdm7a drives transcriptional and metabolic reprogramming toward Fib-Mac states, expands Fib-Macs, and exacerbates bleomycin-induced fibrosis, consistent with reduced KDM7A in human disease. Mechanistically, Kdm7a loss increases H3K27me2 at the Tlr8 enhancer, reduces TLR8 expression, and promotes Fib-Mac polarization.

An analogue memory built from a two-dimensional material with antimony contacts enables very high, energy-efficient in-memory searches and k-nearest-neighbour classification, offering a scalable, low-power hardware platform for real-time edge artificial intelligence applications.

Low progesterone-to-oestradiol ratio during perimenopause increases Alzheimer’s disease (AD) risk by disrupting ERRα, hence impairing neuronal cholesterol and energy balance. ERRα is a key regulator linking peripheral hormonal changes to female-biased AD susceptibility.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Programable coatings are promising for information encryption, though it is challenging to design stimuli-responsive materials. Here the authors integrate a photochromic switch into a polymer system for programmable encryption.

Thermal [2+2] cycloaddition reactions are symmetry-forbidden due to ground-state orbital symmetry constraints, making them challenging to achieve under non-photochemical conditions. Now a stepwise radical intramolecular thermal crossed [2+2] cycloaddition of N-(homo)allyl gem-difluoroenamines and homoallyl gem-difluorovinyl ethers has been accomplished, through tandem gem-difluoroalkenylation of N-(homo)allylamines and homoallyl alcohols with trifluoromethyl triftosylhydrazones.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Authors present a bispecific antiviral design targeting the virus and the host that simultaneously offers broad-spectrum protection against multiple existing transmissible human-pathogenic coronaviruses, including the Paxlovid-resistant SARS-CoV-2 mutants.

Endocytosis of TFR1 plays a crucial role in extracelluar iron uptake. Here the authors revealed that PKCβII facilitates the endocytosis of TFR1 and increases cellular iron levels through the phosphorylation of AAK1, thus promoting ferroptosis of tumor cells.

Silicon materials offer high capacity in Li-ion batteries but suffer from huge volume changes during cycling, requiring external pressure to maintain performance. Here, authors develop a self-healing gel polymer electrolyte that confines silicon expansion without external pressure.

This study shows that the transcriptional targets of NANOG recruits UTP15 to gene promoters in mESCs. There, UTP15 supports the formation of Pol II condensates, thereby activating pluripotency gene transcription independently of its classic role.

In complex reaction systems featuring intricate product and pathway possibilities, achieving simultaneous control over multiple selectivities remains highly challenging. Now it has been demonstrated that biomimetic peptide–phosphonium salts can concurrently impart stepwise and stereochemical control in the asymmetric Atherton–Todd reaction, which enables efficient access to diverse P-stereogenic platform molecules.

Insulin-activated ataxia-telangiectasia mutated (ATM) regulates glucose metabolism. Here the authors report that its disruption in a mouse model of ataxia-telangiectasia leads to insulin resistance, glutamine dependence, and selective Purkinje cell degeneration, while α-Ketoglutarate supplementation shows promise in mitigating neurodegeneration.

HOXA2 expression was inhibited by aberrant hypermethylation, leading to decreased SIRT1 levels, which could increase ATF6 acetylation and activation as well as subsequent ER stress, resulting in renal damage in CKD-related fibrosis.

Allele-specific expression of LINC02449 at rs149707223 in monozygotic twins with psychiatric disorders drives social deficits and repetitive behaviors in mice via CPLX1-mediated excitatory transmission, underscoring ASE as a key regulatory mechanism.

Developing porous crystalline materials with tailored properties is challenging because of the vast design space and the high cost of screening. Now, highly fluorescent covalent organic frameworks have been identified through an AI-assisted iterative experiment–learning cycle workflow that integrates electronic configuration and quantum-level insights into the learning process.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Bacterial N⁶-methyladenine (6mA) is an intrinsic epigenetic marker. Here, the authors evaluate and compare eight third-generation sequencing tools for 6mA identification, assessing performance in terms of motif discovery, site-level accuracy, single-molecule accuracy, and outlier detection.

Wireless modules within self-powered Internet of Things devices are affected by external interference. Here, authors reported a moist-electromagnetic coupling effect by polymer diodes for synergistic moist energy harvesting and electromagnetic protection.

Current seasonal flu vaccines hardly protect against emerging H5N1 such as clade 2.3.4.4b circulating in cattle. Here, the authors show that a single intranasal immunization of DelNS1-H5N1 vaccine candidates provides effective protection and sustained immunity against highly pathogenic avian influenza A viruses.