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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Ma, Li, and colleagues present a virtual tissue staining method that overcomes data mismatch by separating image generation from spatial alignment. This approach produces highly accurate diagnostic images that expert pathologists cannot distinguish from real chemical stains.

Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

Wearable energy-harvesting devices suffer from low electrical output and poor wear comfort. Here, authors develop a self-powered fabric with good wear comfort that pumps sweat directionally, achieving 6.3 °C skin cooling and a 0.40 mA·cm⁻² DC current output for practical wearable power supply.

This study reports selective CO₂ reduction to ethanol in pure water under natural sunlight using a carefully designed Cuδ⁺O/boron nitride flower heterostructured photocatalyst.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

Microcavity exciton polaritons are a promising platform for optical parametric processes. Here, authors achieve efficient parametric emission with strong phase coherence in quantum confined microcavities, demonstrating a polariton supersolid phase at room temperature.

Environmental Robustness Index is established to bridge the gap between laboratory and field performance of solar evaporation technologies. Design principles for managing heat transport enable stable water production in diverse climatic conditions.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

This study shows that tropical cyclone heavy rainfall has extended inland along the coasts of the Northern Hemisphere with a rate of 3.8 km per decade since 1980. Nearshore sea-surface warming drives this expansion, with coastal urbanization further amplifying the effect. These findings highlight increasing flood risk for inland populations as cities grow.

Researchers boosted the thermoelectric performance of the ionic-bonded compound MnTe by manipulating chemical bonding, achieving improved TE conversion efficiency and zT values via increased electron delocalization and suppressed phonon transport.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

Zinc-based flow batteries offer safe, low-cost energy storage but suffer dendrite-related failure. Here, authors employ quantum sensing to link local temperature gradients to dendrite growth and develop a liquid metal electrode that mitigates hotspots, enabling long-term stable cycling.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Cryo-EM structures of the Azoarcus group I intron capture its progression from pre-splicing to circular RNA products, revealing coordinated RNA rearrangements that drive catalysis and a two-step circularization pathway.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

Removing trace acetylene from ethylene is vital for plastic production, yet catalysts often overreact and waste the product. This work reveals that palladium dual-atom catalyst on carbon greatly speeds the reaction while keeping ethylene intact.

Tight regulation of thymic T cell development is critical for immune homeostasis and leukemia prevention. Here, the authors identify USP10 as a MYC-induced deubiquitinase stabilizing SOX4 in early T cell development and T-cell acute lymphoblastic leukemia progression, while USP10 inhibition delays leukemogenesis in mice.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Data storage using proteins offers high capacity and stability, however, expressing unnatural proteins with random sequences often fails. Here the authors encode digital data into amino acid sequences based on collagen-like protein templates to allow stable data storage and retrieval.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Given the interest in extracellular vesicles there is a need for simple short scaffold proteins for efficient targeting and cargo loading. Here, the authors identify a candidate scaffold protein and find the truncated version allows for efficient loading which outperforms current scaffold proteins, demonstrating application in sepsis therapy.

Self-assembled hole-selective molecules can enable high performance in perovskite solar cells, but controlling the hole extraction efficiency is challenging. Tianyu Li et al. address this by designing molecules that adopt a quasi-random orientation on the substrate.

Current artificial intelligence lacks the ability to perceive the emotions conveyed through human touch. Here, the study develops a bio-inspired hairy electronic skin that can recognize emotions from touch, facilitating natural affective communication for robots.

Developing efficient battery electrolytes is a slow and complex challenge. Here, authors create a deep active learning framework that rapidly identifies high-performance materials and transfers knowledge to new designs, tripling battery lifespan while requiring significantly fewer experiments.

Sunlight triggers ammonium chloride in aerosols to produce Cl₂ gas, explaining 12-55% of daytime levels. This chlorine source, boosted by black carbon, impacts atmospheric oxidation.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

A hallmark of the interaction between flat band and dispersive band states in quantum materials is the flat band resonance. Here, the authors report the observation of a flat band resonance in the kagome bilayer material CsCr₆Sb₆ originating from the doublet kagome bands of the bilayer unit.

E. coli is common in humans, animals and the environment but the extent of circulation between ecological niches is unclear. Here, the authors sample ~1,000 E. coli strains from different urban aquatic ecosystems in Hong Kong and describe genomic relatedness of markers of antimicrobial resistance.

Rechargeable sodium-ion batteries are limited by slow ion movement in cathodes. Here the authors show that introducing solvent molecules into layered cathodes improves ion transport and reaction kinetics, enabling fast-charging batteries with stable long-term performance.

Novel treatments are needed for type 2 diabetes mellitus which target insulin resistance, lipid metabolism dysregulation, and gut microbiome dysbiosis. Here the authors engineered a probiotic to tolerate oxidative stress, an alleviate type 2 diabetes in mice by activating host metabolic pathways.

Here, the authors show that a chiral plasmonic nanoparticle coupled to monolayer MoS₂ creates a magnetic-field-free 19 meV valley splitting and extends valley polarization lifetime at room temperature, paving the way to tunable, longer-lived valley-encoded dynamic control.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

Avalanche field-effect transistors (AFETs) based on 2D materials have shown promising results, but they are normally limited by high breakdown fields and low ionization indexes. Here, the authors report AFETs based on anisotropic 2D ReSe₂ showing a breakdown electric field down to 2.55 kV/cm and an ionization index up to 38.79.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

Here, the authors demonstrate that Inhibiting PTBP1 corrects E2A splicing imbalance, reprograms muscle cell development, and rescues defective muscle regeneration in a Duchenne muscular dystrophy mouse model.

Mitochondrial genomes of bilateral animals exhibit high variability in architectural rearrangement rates, but the reason for this disparity remains unknown. This study provides evidence that purifying selection mediated by locomotory capacity and species ecology is a major driver of mitogenomic architectural evolution.

Room-temperature multiferroic materials are highly demanded for designing next-generation of spintronic devices. Here, the authors demonstrate an emergent room-temperature ferrimagnetism and polar phase in highly strained La₂CoRuO₆ epitaxial films through engineered 3d−4d cation ordering.

FRIL is an antiviral legume lectin that recognizes complex type N-glycans. Here, authors discover a process to activate the inert recombinant lectins, and engineer a shift of FRIL’s glycan recognition to high mannose N-glycans.

Urban shade from trees and buildings is unevenly distributed globally, with lower-income and peripheral neighbourhoods consistently having less sidewalk shade despite higher heat vulnerability, underscoring the need for equity-focused interventions.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

The rapid rise of artificial intelligence pushes the need for more efficient computing. Here, authors propose an electrically reconfigurable, all-optical logic processing unit based on the combination of Kerr nonlinearities and high-entropy MXene surface terminations. They achieve an accuracy of 97.7% for digit recognition on the MNIST dataset.

In this study, the authors identify a microcircuit containing three subgroups of neurons associated with sensory-induced escape in the mouse temporal association cortex (TeA): sensory, sensory-motor decision and motor command neurons.