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By forming an electron reservoir in the centre of a gallium nitride nanowire p–n diode, a single two-terminal device can be created that offers sensing, memory and synaptic functionalities, and arrays of such devices can be used to denoise and identify optical images.

A gravity-driven organoid perfusion (GDOP) chip is developed to establish uniform TNBC organoids for three-drug sensitivity testing via morphological and grayscale changes, and to generate brain organoids supporting further drug toxicity research.

This Review encompasses recent developments in photochemical, electrochemical and electrophotochemical C–N coupling reactions, focusing on metal-catalysed and metal-free methodologies under diverse activation conditions. It highlights sustainable and versatile synthetic strategies for C–N bond formation.

A Ni single-atom catalyst on CdS efficiently converts polylactic acid bioplastic into hydrogen and valuable chemicals using sunlight, offering a sustainable strategy for bioplastic waste recycling.

Selective paraffin capture to afford high-purity olefins directly is critical but still challenging. Herein, the authors discover a distinctive ultramicroporous material featuring closely packed and linearly-extended isophthalic acid units and thus serving as a paraffin nano-trap for the efficient production of ultra-high purity olefins from paraffins.

The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

This paper reports engineering of metal vacancy to activate lattice oxygen in NiO, enabling photocatalytic ethane dehydrogenation to ethylene at 604.5 μmol g⁻¹ h⁻¹ with 100% selectivity and stable 200-cycle recyclability via a light-enhanced Mars-van Krevelen mechanism.

Alkaline hydrogen production needs stable catalysts, but the electrical double layer is overlooked. Here, the authors report a dense epitaxial hydroxide layer that strengthens the double layer, prevents catalyst leaching, and enhances material stability for 1,400 h in an industrial electrolyzer.

Researchers developed a porous material ZU-921 that solves a key challenge in removing multiple different types of impurities through fine-tuning pore chemistry, enabling the one-step production of high-purity propylene.

Enhancing corrosion resistance is crucial for efficient electrocatalysts in the acidic oxygen evolution reaction. Here, the authors report the strategic manipulation of local compressive strain to improve the anti-corrosion properties of Co3O4, demonstrating stability for over 400 hours at 30 mA cm^-2.

Despite over half a century of development, catalysts still cannot mimic the efficiency of plants in producing oxygen. By considering spatiotemporal aspects in electrocatalyst design, researchers can transplant the concept of direct oxo–oxo coupling from natural metalloenzymes to heterogeneous catalyst surfaces, thus pushing oxygen-evolution activity beyond conventional limits.

Selective photo-oxidation of CH₄ to value-added C₁ oxygenates remains challenging. Here, the authors propose construct mono-copper sites within a framework platform to optimize O₂ activation, enabling highly selective conversion of CH₄ to HCHO.

Nickel-rich Li-ion positive electrodes face challenges such as high cost and poor cycling stability. Here, authors show that quenching heat treatment can lead to more stable performance at high voltages, with synchrotron analyses revealing the roles of surface chemistry and bulk charge distribution.

A comparative analysis of bat genomes, including five newly assembled chromosome-scale genomes, provides insights into the diversification of horseshoe bats and reveals molecular adaptations with a potential role in antiviral immune response.

Maintaining electrode performance under high power is a major challenge for batteries. Here, authors develop a porous organic framework electrode that intermittently applies low currents to release trapped ions, enabling a repeatable capacity-refreshing strategy and over 60,000 cycles at 20 C-rate.

Accurate end-to-end deep learning models for adsorption prediction in porous materials would help its discovery. Here, the authors present DeepSorption, a spatial atom interaction learning network to predict structure-adsorption from atomic coordinates and chemical element types.

N⁶-methyladenosine (m⁶A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m⁶A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m⁶A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.

Atomic-level coordination influences the properties of single-atom-catalysts but is difficult to precisely engineer. Here, authors study the role of local symmetry manipulation, finding planar-symmetry-broken CuN₃ catalysts outperform highly symmetrical CuN₄ for CO₂ electroreduction to formic acid.

Targeting the immune-stimulatory receptor 4-1BB has only yielded modest benefit in cancer treatment. In this study, the authors show that CD73 expression on effector T cells sustained by TGF-β drives tumor resistance to anti-4-1BB therapy and therefore TGF- β blockade can be used to overcome such resistance.

Single-atom catalysts (SACs) can increase atom efficiency and show remarkable catalytic performance compared with their bulk analogues; however, direct fabrication in high yield is challenging. Now, a 3D printing approach realizes the controlled and precise synthesis of SACs with desired geometries.

Hydroxyl radicals (OH) determine the tropospheric self-cleansing capacity. This study reveals that reactive aldehyde chemistry plays an important role in OH formation and helps narrow the gap between ambient OH observations and model simulations.

Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.

PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.

The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ubiquitination of Insig-2, stabilising Insig-2 and reducing lipid biosynthesis.

Horseshoe bats are thought to be natural hosts of SARS-CoV-2 but it is unclear whether other bat species are potential hosts. Virus–host receptor binding and infection assays, including receptors of 46 bat species, show dramatic variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species.

Integrating chemical-electric behaviors into optoelectronic synapses holds promise for several applications. Here, the authors report a photoelectrochemical synapse with dual-modal plasticity and chemically-regulated neuromorphic functions.

Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.

Efficient capture of methyl iodide (CH₃I) from high-temperature nuclear off-gas is quite challenging. Here, the authors present two innovative and efficient strategies to adsorb CH₃I at high temperatures in an azolate-based metal-organic framework.

Separating mixtures of hydrocarbons of low molecular weight is desirable but challenging. Here, the authors report a porous material with responsive and self-adaptive properties that enables one-step removal of alkynes and propadiene from cracking gases.

A light-detection electrochemical cell that is based on vertically aligned p–n heterojunction nanowires in an electrolyte environment can exhibit a photoresponse in which the polarity is reversed depending on the wavelength of light.

Designing efficient adsorbents for trace gas removal remains a serious challenge. Here, the authors show promise in layered 2D metal−organic frameworks, often overlooked in favor of 3D frameworks, for separating trace acetylene from ethylene with enhanced performance and high stability.

The bacterial metabolite ADP-heptose activates NF-κB in host cells via alpha-kinase 1 and the TIFA–TRAF signalling pathway.

Chemotherapy drugs can cause pyroptotic cell death by activating caspase-3 to cleave gasdermin E, potentially contributing to their toxicity and adverse effects.