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Materials with polymer-doped chiral organic afterglow are of interest, but spectral diversity is limited. Here, the authors report the development of a material combining polyvinyl alcohol and phosphonic acid derivatives for materials with blue emission afterglow.

While interest in copper nanoclusters has grown due to the high abundance, low cost, and unique properties of copper, modular synthesis remains underdeveloped. Here, the authors report a strategy for constructing structurally well-defined copper nanoclusters through the synergistic combination of photochemical activation and nanoscale ligand-exchange.

Here, Zhang et al. demonstrate that the microbial metabolite indole-3-propionic acid stimulates production of β-hydroxybutyrate in intestinal cells, in turn activating regenerative stem cells to promote mucosal healing in colitis.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

The longevity of leaves determines the overall duration of photosynthesis for plants. This study suggests that climate change drives leaf longevity convergence toward intermediate ranges, which, by altering leaf traits and enhancing photosynthetic capacity, strengthens ecosystem stability and is closely linked to vegetation diversity.

Zinc-metal batteries are restricted by their inherent high activity of aqueous electrolyte. Here, authors report the design of a new class of zinc-based hybrid metal halide solid-state electrolytes, offering a promising avenue for all-solid-state zinc batteries.

Electrochemical hydrogenation of quinoxaline is a promising alternative to traditional methods but is limited by low current density and Faradaic efficiency. Here, the authors report a Ru single atoms doped Co₃O₄ nanosheet catalyst that regulates interfacial water to achieve excellent performance.

Nano-confinement between a capping layer composed of graphene or hexagonal boron nitride and a substrate directs the growth kinetics during chemical vapour deposition, which enables the atomically precise synthesis of 2D transition metal dichalcogenide monolayers, Janus monolayers and van der Waals heterostructures with ultraclean interfaces.

The authors consider the changing sensitivity of the leaf-onset date to temperature (S_T) for boreal deciduous broadleaf forests. S_T increased between 1982–1996 and 1998–2012—potentially linked to enhanced chilling accumulation—but this increase is underestimated in phenology models.

Two-dimensional perovskite phases at the bottom interfaces of solar cells improve performance, but their formation is challenging. To address this, Zhao et al. graft the 2D perovskite-phase precursor onto a functionalized SnO₂ electrode substrate.

Phage therapy is an alternative treatment against biofilm-associated infections. In this case report, phage-antibiotic therapy was used to treat a vascular graft infection caused by a refractory fluoroquinolone non-susceptible Pseudomonas aeruginosa.

Atomically thin nitrogen crystals, termed nitrogene, have been theoretically predicted, but their synthesis has remained elusive so far. Here, the authors report experimental evidence of the formation of nitrogen-based crystalline structures compatible with nitrogene on Ag(100) surfaces via ion-beam-assisted epitaxy.

A general protocol for high-dimensional entangling gates is developed and applied for two four-dimensional qudits encoded in orbital angular momentum (OAM). The phase-locking technique stabilizes OAM sorters, leading to a process fidelity within a range from 0.71 to 0.85.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A short peptide derived from a commensal-fungal-secreted protein promotes repair in models of colon epithelial damage when delivered directly or via probiotic microbes.

Liquid-based direct air capture relies on natural gas combustion to drive calcination. Here, the authors present a solar-driven hydrogen-fluidized solar calciner integrated with on-site CO₂ conversion to produce sustainable aviation fuel. The analysis shows its economic feasibility.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Highly ionically conductive and flexible solid-state composite battery electrolytes are engineered by alternately stacking inorganic Li_xM_yPS₃ (M = Cd or Mn) nanosheets with lithium-containing organic polymers in a perpendicular orientation to the surface of the electrodes.

High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

PanoSpace enhances low-resolution spatial transcriptomics data to reconstruct continuous tissue maps at single-cell resolution. In cancer tissues and mouse brain, it refines cell localization, identity, gene expression and microenvironmental interactions.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Improving catalysts for producing carbonates remains a challenge due to limited activity and durability. This study shows a bismuth–ceria catalyst that enhances reaction steps through remote electronic effects and can be easily regenerated.

Tip-focused radiofrequency perforation enables soft, bloodless implantation of flexible electronic hairs, advancing semi-implantable electrophysiology for prosthetics and human–machine interfaces.

This study shows that the transcriptional targets of NANOG recruits UTP15 to gene promoters in mESCs. There, UTP15 supports the formation of Pol II condensates, thereby activating pluripotency gene transcription independently of its classic role.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

The ambiphilic reactivity of alkyl sulfonyl fluorides in stereoselective cyclopropanation under Pd(II) catalysis is reported. The method provides convenient access to cis-disubstituted cyclopropanes that are otherwise challenging to access. A representative carboxylic acid cyclopropane building block is scaled up to 100 mmol, demonstrating the practicality of this transformation.

A single umbilical cord blood unit of CD34⁺ HSPCs produces a high number of CD19 CAR-iNK cells using a modified cell culture method.

The coexistence of ferroelectricity and nonreciprocal transport in metallic material has been a challenge. The authors demonstrate that the polarity-induced nonreciprocal transport can be nonvolatile and electrically reversed in ferroelectric polar metal WTe₂.

Prostate cancer diagnosis require MRI analysis, however, scoring can vary between clinicians. Here, the authors develop ProAI to detect prostate cancer from imaging.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

The genetic mechanisms of why polyploid plants exhibit adaptive advantages over diploids are unclear. Here, the authors assemble the autotetraploid alfalfa genome, incorporate it into a pangenome analysis, and reveal the trade-off between adaptive advantages and evolutionary constraints mediated by tetra-copy core genes.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Low-threshold exciton multiplication in twisted heterobilayers features long-lived interlayer excitons, enhancing emission and photocurrent quantum efficiencies.

Cells can sense mitochondrial damage through signalling via an unimported mitochondrial targeting sequence.

Environmental Li pollution and health problems have been becoming an important concern worldwide. Here, the authors show that Li exposure causes trophoblast cell ferroptosis and thus induces unexplained miscarriage through a non-canonical MBOAT1 pathway.

The authors demonstrate that a cell’s external environment can physically control its genes. Osmotic pressure alters intranuclear crowding, shifting the equilibrium of proteins binding to dCas9-SunTag complex and thereby regulating gene expression.