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The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Analyses of sequencing data from 75,602 children referred for genetic testing from 2016 to 2025 provide insights on the association between pathogenic germline variants and childhood cancer.

Chen, Gu, Zhang, Zhang, et al. developed a computer model called KDMF to help doctors identify sepsis patients who are likely to develop ARDS and predict their risk of death within 28 days. The model, combining multiple types of patient data, was highly accurate at predicting both the onset of ARDS and patient survival.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

In a multi-cohort longitudinal study integrating continuous glucose monitoring and circulating proteomics, cumulative age-related disease trajectories shape daily glycaemic variability and postprandial response to standardized meals.

Generation of light with desirable amplitude and phase profiles with nonlinear wavefront shaping is of great interest for optical technologies. Here, the authors demonstrate efficient nonlinear beam shaping using three-dimensional lithium niobate photonic crystals fabricated using a femtosecond-laser-engineering technique.

Developing earth-abundant catalysts for the chlorine evolution reaction is vital for a sustainable chlor-alkali industry. Here, the authors report a cerium modified cobalt oxide where cerium induces active site transfer from oxygen to cobalt atoms, achieving high activity and long-term stability.

The recent global mpox outbreaks underscore the critical need for antiviral development, hindered by the complexity of the MPXV genome. Using yeast TAR cloning, CRISPR-Cas9, and Lambda Red recombination to engineer replication-defective MPXV, the authors offer a platform for therapeutic research and identify G243-1720, a compound with a tecovirimat-like mechanism, as a promising anti-poxvirus compound.

Thermodynamics typically favour the formation of crystals with flat facets. Here, the authors report an approach for the synthesis of curved boundaries in titania single crystals, composed of high index microfacets.

The PrimeGen framework is a multi-agent large language model system used to navigate intricate primer design workflows for amplicon sequencing.

Here, the authors show that the gut commensal Parabacteroides distasonis alleviates insulin resistance via nicotinic acid-intestinal GPR109a axis activation, a process promoted by Dendrobium officinale polysaccharide.

Balancing comfort, wearability and integration for human-machine interaction systems is difficult. The authors develop a hybrid-fabric wristband system, where spun-film sensors are integrated into textiles, enabling a lightweight, breathable, and stretchable device.

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Genome-wide association analyses identify risk loci for breast cancer in women of African ancestry. Polygenic risk scores derived from these data improve ancestry-specific risk prediction.

Proton-coupled electron transfer (PCET) has been observed in chemical, energy, and biological transformation processes. Here we demonstrate that the rate of PCET and oxygen evolution reaction can be dramatically enhanced by tuning crystal orientation and the correlated proton diffusion.

Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell death mechanism, is the dominant cell death pathway during virotherapy.

Hogan and colleagues report that the RNA helicase Ddx21 mediates Vegfc-stimulated lymphangiogenesis during zebrafish development through controlling rDNA transcription and ribosome biogenesis in endothelial cells.

Designing atomically monodispersed heterogeneous catalysts with uniform active sites and high atom utilization efficiency is of fundamental and practical interest. Here, the authors report a Pt2/mpg-C3N4 catalyst showing enhanced catalytic performance toward the selective hydrogenation and epoxidation

Electron–phonon coupling is a key physical process in condensed matter systems that plays a crucial role in phenomena such as superconductivity. Here, the authors characterize the role of electron–phonon coupling in the topological superconductor candidate 2M-WS2, indicating a robust and mode-selective coupling that informs the nature of its relatively high superconducting transition temperature.

Here, the authors combine 3D printing and liquid metal filling techniques to fabricate customised probeheads for magnetic resonance experiments. They demonstrate in situ electrochemical nuclear magnetic resonance analysis, reaction monitoring with continues-flow separation and small-sample imaging.

Neutrophil extracellular traps (NETs), composed of DNA and proteases, contribute to the innate immune response by capturing pathogens. Here, Chang et al. identify a NET-degrading DNase in Plasmodiumparasites and show that immunization with this protein provides protective immunity in a malaria mouse model.

We propose and experimentally demonstrate a non-reciprocal near-infrared femtosecond laser-writing technique for reconfigurable three-dimensional nanoscale ferroelectric domain engineering in LiNbO₃ crystals.

Electrocatalytic reduction of nitrogen has emerged as a sustainable means for the production of ammonia. Here the authors design bimetallic Fe–Co single-atom catalysts dispersed on carbon that enable unprecedented ammonia yield rates.

Thin separators can improve batteries’ energy densities but increase cell shortcircuit risks. Here, the authors report an improved thin metal-organic frameworks separator to improve the dendrite formation resistance and cycling stability of high-voltage lithium battery in carbonate electrolytes.

Xu Tan, Yong Yang and colleagues identify patients with epidermolysis bullosa harboring mutations in KLHL24, which encodes a cullin 3–RBX1 ubiquitin ligase substrate receptor. They find that truncating mutations stabilize the protein by abolishing autoubiquitination, leading to enhanced ubiquitination and degradation of KRT14, the target substrate of KLHL24.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

eQTL analysis of human brain RNA-seq data targeted to genes within the 10q24.32 schizophrenia-associated locus reveals that the risk SNP in this region is selectively associated with expression of BORCS7 and a human-specific isoform of AS3MT across multiple independent samples. Expression of only the associated AS3MT isoform is higher in tissue from humans with schizophrenia than in healthy controls.

In glioma STAT3 signaling contributes to gliomagenesis. Here, the authors show that Smad6 expression correlates with poor survival and is overexpressed in glioma cells, and regulates STAT3 activity via negatively regulating PIAS3.

Copper-mediated SEC14L3 activates the ERK/YY1/FDX1 axis to promote cuproptosis and suppress hepatocellular carcinoma progression.

The causative mechanism for the immunodeficiency and autoinflammatory disease XLPDR is unknown. Burstein and colleagues show that XLPDR is caused by disruption of POLA1, which encodes a DNA polymerase subunit; this, in turn, leads to dysregulated production of type I interferons.